Patents by Inventor Clara Fronticelli

Clara Fronticelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blood substitutes
    Patent number: 7329641
    Abstract: The functional characteristics of heme proteins can be modified to produce hemoglobins that can be used as blood substitutes in different therapeutic applications. Stable polymers of tetrameric hemoglobin, and of myoglobin molecules, are provided for use in the blood substitutes.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: February 12, 2008
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Clara Fronticelli, William S. Brinigar
  • Blood substitutes
    Publication number: 20050227912
    Abstract: The functional characteristics of heme proteins can be modified to produce hemoglobins that can be used as blood substitutes in different therapeutic applications. Stable polymers of tetrameric hemoglobin, and of myoglobin molecules, are provided for use in the blood substitutes.
    Type: Application
    Filed: November 1, 2004
    Publication date: October 13, 2005
    Inventors: Clara Fronticelli, William Brinigar
  • Polymeric hemoglobin mutants
    Patent number: 6780892
    Abstract: Human &bgr;-globin mutant polypeptides comprise the amino acid sequence of normal human &bgr;-globin modified by (i) the substitution or deletion of Cys at amino acid positions 93 and 112, and (ii) the substitution of a Cys fore a non-Cys amino acid at one other position in the polypeptide, preferable Ser at amino acid position 9. Modified human hemoglobins containing this or other &bgr;-globin mutations, and/or an &agr;-globin mutation, are provided, as well as polymers of such modified hemoglobins. Nucleic acids, vectors, and transformed host cells for producing the &bgr;-globin mutants are provided.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: August 24, 2004
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventor: Clara Fronticelli
  • Hemoglobin intramolecularly cross-linked withlong chain divalent reagents
    Patent number: 5387672
    Abstract: Stroma-free hemoglobin cross-linked with reagents that mimic 2,3-diphosphoglycerate and transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for adequate periods of time, and thus can be used in fluids for transporting oxygen is described.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: February 7, 1995
    Assignee: The University of Maryland at Baltimore
    Inventors: Enrico Bucci, Clara Fronticelli
  • Hemoglobin intramolecularly cross-linked with trivalent reagents
    Patent number: 5290919
    Abstract: Stroma-free hemoglobin cross-linked with reagents that mimic 2,3-diphosphoglycerate and transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for adequate periods of time, and thus can be used in fluids for transporting oxygen is described.
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: March 1, 1994
    Assignee: The University of Maryland Baltimore
    Inventors: Enrico Bucci, Clara Fronticelli
  • Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
    Patent number: 5239061
    Abstract: The present invention relates to modified .beta.-chains of human hemoglobin having an oxygen binding affinity equal to or less than natural human hemoglobin. The modified the .beta.-chain of human hemoglobin of the invention preferably has at least one chloride binding site not present in .beta.-chain of natural human hemoglobin.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: August 24, 1993
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Clara Fronticelli, Enrico Bucci, William Brinigar
  • Intramolecularly cross-linked hemoglobin and method of preparation
    Patent number: 4584130
    Abstract: Stroma-free hemoglobin cross-linked with reagents that mimic 2,3 diphosphoglycerate and transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for adequate periods of time and thus can be used in fluids for transporting oxygen; reagents for cross-linking stroma-free hemoglobin and method for cross-linking stroma-free hemoglobin.
    Type: Grant
    Filed: March 29, 1985
    Date of Patent: April 22, 1986
    Assignee: University of Maryland
    Inventors: Enrico Bucci, Clara Fronticelli-Bucci, Ramachandra Hosmane