Abstract: Methods, systems, and computer-readable media for cancer susceptibility modelling and screening for a patient. The computer-readable medium includes executable instructions to perform a method for receiving input data associated with cancer and a patient, and determining a susceptibility model and a data enrichment rate based on the input data. The computer-readable medium also includes executable instructions for acquiring multi-domain patient data based on the susceptibility model and data enrichment rate, wherein the patient data comprises at least proteomic data. The computer-readable medium also includes executable instructions for generating cancer susceptibility data for the patient, and determining a cancer screening model for the patient based on the susceptibility data, using a machine learning approach.