Patents by Inventor CLARK PATRICK ALLPHIN

CLARK PATRICK ALLPHIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE
    Publication number: 20230078754
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Application
    Filed: September 2, 2022
    Publication date: March 16, 2023
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • Formulations of (R)-2-amino-3-phenylpropyl carbamate
    Patent number: 11439597
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: September 13, 2022
    Assignee: Axsome Malta Ltd.
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • Alcohol-resistant drug formulations
    Patent number: 11400052
    Abstract: The invention relates to modified release oral formulations of therapeutic agents, including gamma hydroxybutyrate (GHB), paracetamol, codeine or oxycodone, which are resistant to alcohol induced dose dumping. Provided are formulations that have improved resistance to rapid release of the active ingredient in the presence of increasing amounts of alcohol. Also provided are formulations that can reduce or prevent the release of the active ingredient following exposure to alcohol-containing media. The invention also relates to methods of making the formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: August 2, 2022
    Assignee: Jazz Pharmaceuticals Ireland Limited
    Inventors: Edwin Walsh, Clark Patrick Allphin
  • ALCOHOL-RESISTANT DRUG FORMULATIONS
    Publication number: 20220160640
    Abstract: The invention relates to modified release oral formulations of therapeutic agents, including gamma hydroxybutyrate (GHB), paracetamol, codeine or oxycodone, which are resistant to alcohol induced dose dumping. Provided are formulations that have improved resistance to rapid release of the active ingredient in the presence of increasing amounts of alcohol. Also provided are formulations that can reduce or prevent the release of the active ingredient following exposure to alcohol-containing media. The invention also relates to methods of making the formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 26, 2022
    Inventors: Edwin WALSH, Clark Patrick ALLPHIN
  • FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE
    Publication number: 20210205227
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Application
    Filed: January 21, 2021
    Publication date: July 8, 2021
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • IMMEDIATE RELEASE FORMULATIONS AND DOSAGE FORMS OF GAMMA-HYDROXYBUTYRATE
    Publication number: 20210093575
    Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 1, 2021
    Inventors: Andrea ROURKE, Maura Patricia MURPHY, James Frederick PFEIFFER, Clark Patrick ALLPHIN, Alya Khan McGINLAY
  • ALCOHOL-RESISTANT DRUG FORMULATIONS
    Publication number: 20200330393
    Abstract: The invention relates to modified release oral formulations of therapeutic agents, including gamma hydroxybutyrate (GHB), paracetamol, codeine or oxycodone, which are resistant to alcohol induced dose dumping. Provided are formulations that have improved resistance to rapid release of the active ingredient in the presence of increasing amounts of alcohol. Also provided are formulations that can reduce or prevent the release of the active ingredient following exposure to alcohol-containing media. The invention also relates to methods of making the formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
    Type: Application
    Filed: November 19, 2019
    Publication date: October 22, 2020
    Inventors: Edwin WALSH, Clark Patrick ALLPHIN
  • FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE
    Publication number: 20200085748
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Application
    Filed: November 20, 2019
    Publication date: March 19, 2020
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • Formulations of (R)-2-amino-3-phenylpropyl carbamate
    Patent number: 10512609
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 24, 2019
    Assignee: Jazz Pharmaceuticals Ireland Limited
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE
    Publication number: 20190117578
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Application
    Filed: December 19, 2018
    Publication date: April 25, 2019
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • Formulations of (R)-2-amino-3-phenylpropyl carbamate
    Patent number: 10195151
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: February 5, 2019
    Assignee: Jazz Pharmaceuticals International III Limited
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE
    Publication number: 20180064652
    Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.
    Type: Application
    Filed: September 5, 2017
    Publication date: March 8, 2018
    Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
  • IMMEDIATE RELEASE FORMULATIONS AND DOSAGE FORMS OF GAMMA-HYDROXYBUTYRATE
    Publication number: 20180042855
    Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 15, 2018
    Inventors: Andrea Marie ROURKE, Maura Patricia MURPHY, James Frederick PFEIFFER, Clark Patrick ALLPHIN, Alya Kahn MCGINLAY
  • Immediate release formulations and dosage forms of gamma-hydroxybutyrate
    Patent number: 9795567
    Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: October 24, 2017
    Assignee: JAZZ PHARMACEUTICALS, INC.
    Inventors: Andrea Marie Rourke, Maura Patricia Murphy, James Frederick Pfeiffer, Clark Patrick Allphin, Alya Kahn McGinlay
  • IMMEDIATE RELEASE FORMULATIONS AND DOSAGE FORMS OF GAMMA-HYDROXYBUTYRATE
    Publication number: 20140348917
    Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
    Type: Application
    Filed: June 3, 2014
    Publication date: November 27, 2014
    Applicant: Jazz Pharmaceuticals, Inc.
    Inventors: Andrea Marie Rourke, Maura Patricia Murphy, James Frederick Pfeiffer, Clark Patrick Allphin, Alya Kahn McGinlay
  • Immediate release formulations and dosage forms of gamma-hydroxybutyrate
    Patent number: 8778398
    Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: July 15, 2014
    Assignee: Jazz Pharmaceuticals, Inc.
    Inventors: Andrea Marie Rourke, Maura Patricia Murphy, James Frederick Pfeiffer, Clark Patrick Allphin, Alya Khan McGinlay
  • IMMEDIATE RELEASE FORMULATIONS AND DOSAGE FORMS OF GAMMA-HYDROXYBUTYRATE
    Publication number: 20110111027
    Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
    Type: Application
    Filed: May 4, 2010
    Publication date: May 12, 2011
    Applicant: JAZZ PHARMACEUTICALS, INC.
    Inventors: ANDREA MARIE ROURKE, MAURA PATRICIA MURPHY, JAMES FREDERICK PFEIFFER, CLARK PATRICK ALLPHIN, ALYA KHAN MCGINLAY