Patents by Inventor Clark T. Hung

Clark T. Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10881098
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: January 5, 2021
    Assignees: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Patent number: 10722370
    Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: July 28, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
  • Publication number: 20200054002
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Application
    Filed: September 5, 2019
    Publication date: February 20, 2020
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Publication number: 20190175349
    Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 13, 2019
    Inventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
  • Patent number: 10251751
    Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: April 9, 2019
    Assignee: The Trustees of Columbia University In The City of New York
    Inventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
  • Publication number: 20180310548
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Application
    Filed: June 28, 2018
    Publication date: November 1, 2018
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Patent number: 10039277
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 7, 2018
    Assignees: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Publication number: 20170260509
    Abstract: The present disclosure relates to methods and systems of tissue engineering, and, more particularly, to optimization of tissue regeneration using cell cycle synchronization of stem cells.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 14, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Clark T. HUNG, J. Chloë BULINSKI, Andrea R. TAN
  • Publication number: 20170056181
    Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.
    Type: Application
    Filed: March 11, 2015
    Publication date: March 2, 2017
    Inventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
  • Patent number: 9506027
    Abstract: A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: November 29, 2016
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Mark A. Borden, Eric G. Lima, Clark T. Hung, Shashank Ramesh Sirsi
  • Patent number: 9321993
    Abstract: The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: April 26, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Clark T. Hung, Grace D. O'Connell
  • Publication number: 20160088833
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 31, 2016
    Applicants: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Patent number: 9220258
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: December 29, 2015
    Assignees: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Publication number: 20140141500
    Abstract: A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 22, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Mark A. BORDEN, Eric G. LIMA, Clark T. HUNG, Shashank Ramesh SIRSI
  • Publication number: 20140135625
    Abstract: Ultrasound methods, devices, and systems are described which support a useful compromise in terms of spatial resolution and temporal resolution for capturing motion in tissue structures. Tissue engineering articles, methods, systems, and devices which employ ultrasound to deliver biological agents to selected regions of a tissue scaffold, deliver mechanical stimulation to cells growing in a tissue scaffold, and enhance the perfusion of fluids through tissue scaffolds.
    Type: Application
    Filed: October 18, 2013
    Publication date: May 15, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Elisa E. KONOFAGOU, Clark T. HUNG, Jean PROVOST, Jianwen LUO, Stanley J. OKRASINSKI, III, Stéphane THIÉBAUT, Vu Thanh-Hieu NGUYEN
  • Publication number: 20140091491
    Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
    Type: Application
    Filed: December 12, 2013
    Publication date: April 3, 2014
    Applicants: The Trustees of Columbia University in the City of New York, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
  • Patent number: 8617892
    Abstract: A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: December 31, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Mark A. Borden, Eric G. Lima, Clark T. Hung, Shashank Ramesh Sirsi
  • Patent number: 8608801
    Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: December 17, 2013
    Assignees: The Trustees of Columbia University in the City of New York, The Curators of the University of Missouri
    Inventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
  • Publication number: 20130202567
    Abstract: The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects.
    Type: Application
    Filed: June 17, 2011
    Publication date: August 8, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Clark T. Hung, Grace D. O'Connell
  • Publication number: 20120214238
    Abstract: A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.
    Type: Application
    Filed: August 31, 2010
    Publication date: August 23, 2012
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Mark A. Borden, Eric G. Lima, Clark T. Hung, Shashank Ramesh Sirsi