Patents by Inventor Clark W. Distelhorst

Clark W. Distelhorst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of BCL-2
    Patent number: 8445441
    Abstract: A purified polypeptide for inhibiting binding of BCL-2 to IP3 receptors includes an amino acid sequence consisting of about 10 to 80 amino acids. The amino acid sequence has a sequence identity at least 90% homologous to a portion of SEQ ID NO:1. The polypeptide inhibits binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2 and induces apoptosis in a cell.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: May 21, 2013
    Assignee: Case Western Reserve University
    Inventors: Clark W. Distelhorst, Yiping Rong
  • INHIBITORS OF BCL-2
    Publication number: 20110312896
    Abstract: A purified polypeptide includes about 5 to about 80 amino acids and includes an amino acid sequence corresponding to a portion of SEQ ID NO:1. The polypeptide inhibiting binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2.
    Type: Application
    Filed: August 26, 2011
    Publication date: December 22, 2011
    Inventors: Clark W. Distelhorst, Yiping Rong
  • Inhibitors of BCL-2
    Patent number: 8034779
    Abstract: A purified polypeptide includes an amino acid sequence consisting of about 10 to 80 amino acids, the amino acid sequence having a sequence identity at least 90% homologous to a portion of SEQ ID NO:1. The polypeptide inhibits binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2 and induces apoptosis in a cell.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: October 11, 2011
    Assignee: Case Western Reserve University
    Inventors: Clark W. Distelhorst, Yiping Rong
  • INHIBITORS OF BCL-2
    Publication number: 20090048168
    Abstract: A purified polypeptide includes about 5 to about 80 amino acids and includes an amino acid sequence corresponding to a portion of SEQ ID NO:1. The polypeptide inhibiting binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2.
    Type: Application
    Filed: August 13, 2008
    Publication date: February 19, 2009
    Inventors: Clark W. Distelhorst, Yiping Rong