Patents by Inventor Clarke J. Halfman

Clarke J. Halfman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescence ligand binding assay using charge-matched dye and solvent components
    Patent number: 4816419
    Abstract: Fluorescence ligand binding assay of a sample containing an unknown amount of ligand is performed by making direct intensity measurements. In an immunoassay the sample is in a solution containing dye labeled analyte and an antibody specific to the analyte. Surfactant, added to the solution in an amount sufficient to form micelles, provides markedly different fluorescent intensity from bound and unbound labeled analyte if the surfactant ions and dye ions have the same charge polarity and the analyte moeity has the opposite charge polarity.
    Type: Grant
    Filed: July 9, 1984
    Date of Patent: March 28, 1989
    Assignee: University of Health Sciences/The Chicago Medical School
    Inventor: Clarke J. Halfman
  • Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
    Patent number: 4640898
    Abstract: Fluorescence ligand binding assay of a sample containing an unknown amount of ligand may be performed by making direct intensity measurements. In an immunoassay, for example, the sample may be added to a solution containing fluorescein labeled analyte and then is added an antibody specific to the analyte. Sodium dodecyl sulfate, a surfactant, added to the solution in an amount sufficient to form micelles provides markedly different fluorescent intensity from bound and unbound labeled analyte.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: February 3, 1987
    Assignee: University of Health Sciences/The Chicago Medical School
    Inventor: Clarke J. Halfman