Patents by Inventor Clas A. Sonesson

Clas A. Sonesson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-PHENYL-3-METHOXY-PYRROLIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
    Publication number: 20140135505
    Abstract: The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention and to the use of these compounds for therapeutic applications.
    Type: Application
    Filed: January 22, 2014
    Publication date: May 15, 2014
    Applicant: INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB
    Inventors: Clas SONESSON, Lars SWANSON, Fredrik PETTERSSON
  • NOVEL MODULATORS OF CORTICAL DOPAMINERGIC- AND NMDA-RECEPTOR-MEDIATED GLUTAMATERGIC NEUROTRANSMISSION
    Publication number: 20140128360
    Abstract: The present invention relates to novel substituted phenoxyethylamine derivatives, useful as modulators of cortical and basal ganglia dopaminergic and N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: April 17, 2012
    Publication date: May 8, 2014
    Applicant: Integrative Research Laboratories Swenden AB
    Inventors: Clas Sonesson, Jonas Karlsson, Peder Svensson
  • 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
    Patent number: 8673962
    Abstract: The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention and to the use of these compounds for therapeutic applications.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 18, 2014
    Assignee: Integrative Research Laboratories Sweden AB
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson
  • 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
    Patent number: 8586572
    Abstract: The present invention relates to novel 3-phenyl-azetidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-azetidine derivatives of the invention and to the use of these compounds for therapeutic applications.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: November 19, 2013
    Assignee: Integrative Research Laboratories Sweden AB
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson
  • Modulators of dopamine neurotransmission
    Patent number: 8524766
    Abstract: The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)-methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: September 3, 2013
    Assignee: NSAB, Filial af Neurosearch Sweden AB, Sverige
    Inventors: Clas Sonesson, Peder Svensson, Jonas Karlsson
  • 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
    Patent number: 8501777
    Abstract: The present invention relates to compounds having therapeutic effects against disorders in the central nervous system, and in particular substituted phenylpiperidines of the formula 1: wherein R is as defined herein.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: August 6, 2013
    Assignee: NSAB, Filial AF Neurosearch Sweden AB, Sverige
    Inventor: Clas Sonesson
  • DEUTERATED ANALOGS OF PRIDOPIDINE USEFUL AS DOPAMINERGIC STABILIZERS
    Publication number: 20130197031
    Abstract: The present invention provides novel deuterated analogs of Pridopidine, i.e. 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine. Pridopidine is a drug substance currently in clinical development for the treatment of Huntington's disease. In other aspects the invention relates to pharmaceutical compositions comprising a deuterated analog of Pridopidine of the invention, and to therapeutic applications of these analogs.
    Type: Application
    Filed: August 31, 2011
    Publication date: August 1, 2013
    Applicant: IVAX INTERNATIONAL GMBH
    Inventor: Clas Sonesson
  • Modulators of dopamine neurotransmission
    Patent number: 8492372
    Abstract: The present invention relates to novel 1-(4H-1,3-benzodioxin-2-yl)methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically asdopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: July 23, 2013
    Assignee: Integrated Research Laboratories Sweden AB
    Inventors: Clas Sonesson, Peder Svensson, Mikael Andersson
  • Disubstituted phenylpiperdines/piperazines as modulators of dopamine neurotransmission
    Patent number: 8314126
    Abstract: The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherein R1, R2, R3 and X are as defined.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: November 20, 2012
    Assignee: NSAB, Filial af Neurosearch Sweden AB, Sverige
    Inventors: Clas Sonesson, Lars Swanson, Nicholas Ross Waters
  • Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
    Patent number: 8188301
    Abstract: The present invention relates to the use of compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically to the use of 3-disubstituted phenyl-1-pyrrolidinols for the treatment of central nervous system disorders.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: May 29, 2012
    Assignee: NSAB, Filial af NeuroSearch Sweden AB, Sverige
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson, Nicholas Waters, Susanna Waters
  • NOVEL 3-PHENYL-AZETIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
    Publication number: 20110281835
    Abstract: The present invention relates to novel 3-phenyl-azetidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-azetidine derivatives of the invention and to the use of these compounds for therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: November 17, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson
  • NOVEL 1-ALKYL-3-HYDROXY-3-PHENYLAZETIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
    Publication number: 20110257148
    Abstract: The present invention relates to novel 3-phenyl-azetidine derivatives, useful for modulating dopamine neurotransmission and extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-azetidine derivatives of the invention and to the use of these compounds for therapeutic applications. X is OH; R1 is F or Cl; R2 is H, F or Cl; and R3 is n-Pr, i-Pr, n-Bu, i-Bu, s-Bu or t-Bu.
    Type: Application
    Filed: November 24, 2009
    Publication date: October 20, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson
  • 3-PHENYL-3-METHOXYPYRROLIDINE DERIVATIVES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
    Publication number: 20110257242
    Abstract: The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidine derivatives, useful for modulating dopamine neurotransmission and extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention and to the use of these compounds for therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: October 20, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson
  • 3-PHENYL-3-METHOXYPYRROLIDINE DERIVATIVES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
    Publication number: 20110257241
    Abstract: The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention and to the use of these compounds for therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: October 20, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson
  • MODULATORS OF DOPAMINE NEUROTRANSMISSION
    Publication number: 20110112065
    Abstract: The present invention relates to novel 1-(4H-1,3-benzodioxin-2-yl)methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically asdopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: April 28, 2009
    Publication date: May 12, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Peder Svensson, Mikael Andersson
  • MODULATORS OF DOPAMINE NEUROTRANSMISSION
    Publication number: 20110105462
    Abstract: The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)-methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: April 28, 2009
    Publication date: May 5, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Peder Svensson
  • MODULATORS OF DOPAMINE NEUROTRANSMISSION
    Publication number: 20110105461
    Abstract: The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)-methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: April 28, 2009
    Publication date: May 5, 2011
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Peder Svensson, Jonas Karlsson
  • Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
    Patent number: 7851629
    Abstract: The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines. wherein R1, R2, and R3 are as defined.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: December 14, 2010
    Assignee: NSAB, Filial af Neurosearch Sweden AB, Sverige
    Inventors: Clas Sonesson, Lars Swanson, Nicholas Ross Waters
  • DISUBSTITUTED PHENYLPIPERDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION
    Publication number: 20100256163
    Abstract: The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherein R1, R2, R3 and X are as defined.
    Type: Application
    Filed: June 14, 2010
    Publication date: October 7, 2010
    Inventors: Clas Sonesson, Lars Swanson, Nicholas Ross Waters
  • DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION
    Publication number: 20100197760
    Abstract: The present invention provides compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically to the use of 3-(disubstituted aryl)-pyrrolidines for the treatment of central nervous system disorders.
    Type: Application
    Filed: June 4, 2008
    Publication date: August 5, 2010
    Applicant: NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE
    Inventors: Clas Sonesson, Lars Swanson, Fredrik Pettersson, Nicholas Waters, Susanna Waters