Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: A system for performing real-time labor management and timesheet reporting comprising: a plurality of portable and dedicated time tracking units, with each unit operable to wirelessly transmit timesheet information; and a labor management system operable to receive the timesheet information from each of the time tracking units and thereby maintain the timesheet information for each time tracking unit. Each unit may be dedicated to tracking time and incapable of providing unrelated functions.

Abstract: A system for performing real-time labor management and timesheet reporting comprising: a plurality of portable and dedicated time tracking units, with each unit operable to wirelessly transmit timesheet information; and a labor management system operable to receive the timesheet information from each of the time tracking units and thereby maintain the timesheet information for each time tracking unit. Each unit may be dedicated to tracking time and incapable of providing unrelated functions.

Abstract: A system for performing real-time labor management and timesheet reporting comprising: a plurality of portable and dedicated time tracking units, with each unit operable to wirelessly transmit timesheet information; and a labor management system operable to receive the timesheet information from each of the time tracking units and thereby maintain the timesheet information for each time tracking unit. Each unit may be dedicated to tracking time and incapable of providing unrelated functions.

Abstract: A pressure control valve assembly includes a valve housing having a spring loaded, resilient valve element with reversely curved conical surfaces thereon one of which is seated on a fixed, annular pressure relief seat by a first spring element and the other of which is seated against a spring biased ball check valve that controls flow through a central opening in the valve element defining a vacuum relief path.

Abstract: A child-resistant lock means characterized in that a latch, switch, or like operating member therein adapted to be actuated by the tip of the forefinger is located at the end of an angular passage so that said operating member is inaccessible for operation by the forefinger of a child. The lock means herein is further characterized in that there is a lateral projection thereon adjacent the open end of the angular passage to prevent actuation of the operating member by a slender elongated object such as a stick or pencil.

Abstract: A two piece torque release mechanism includes a metal cover having a peripheral flange with a plurality of circumferentially spaced, cam surfaces each including ramp and notch segments intersecting at a sharp radius point radially inwardly of a land segment; a plurality of integrally formed fingers on a driven member are sprung radially outwardly into operative engagement with the cam surfaces.

Abstract: A pressure vacuum relief assembly for a container includes a housing with a first port in communication with the container and a second port in communication with atmosphere; the housing encloses improved vacuum and pressure relief valve means including first and second diaphragm members each having central openings therein engageable with conical surfaces on vacuum relief and pressure relief seal members; said first and second diaphragms form a control chamber in communication with the first port which is selectively pressurized to cause selective snap movement of each of the diaphragms to control flow across the seal members between atmosphere and the container.