Abstract: A composition of microparticles includes a non-radioactive and a radioactive isotope, and an injection vehicle, for use in the intratumoral treatment of cancer, by combined antitumoral effect of radioactivity and intratumoral microparticle deposition. The antitumoral effect provided by the cytotoxicity of radioactivity is enhanced by a modulation of the tumoral immune response induced by microparticle deposition inside the tumor, thereby decreasing the dose of radioactivity required to treat solid tumors. A method of treating solid tumors using a sub-optimal tumor-volume coverage dose of radioactivity combined with intratumoral microparticle deposition as a mean of tumor control is also disclosed.

Abstract: The disclosure relates to a system for preparing an opening created on an organic wall, comprising: —a supporting body defining a longitudinal axis and having a proximal portion and a distal portion adapted for insertion through the opening; —external clamping elements deployable in an outwardly flaring arrangement relative to the supporting body and able to cover portions of an annular surface of said wall; and—biasing elements arranged to tighten and juxtapose said external clamping elements on said body in order to progressively deform said annular surface so as to shape on said wall a tubular portion extending along the longitudinal axis and form an anchoring clamp consisting of said external clamping elements.

Abstract: The invention relates to a system for performing an anastomosis between an organic wall having an opening and an organic hollow tube, comprising: a body inserted inside the tube and through the opening; external clamping elements defining with said body a tubular portion on the wall and forming an anchoring clamp; a device for connecting said tube and said tubular portion, comprising: suture elements connecting the external clamping elements to the body and each having a first end connected to a tightening device and a second end adapted for being retained on an external clamping element; and a suturing device adapted for moving the second end of the suture elements between a retracted configuration where it is located inside the tube, and an anchored configuration where it is retained on an external clamping element after passing through the tube.