Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.

Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.

Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.

Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: An annular wall which transversely connects longitudinal walls of an annular combustion chamber of a turbine engine is disclosed. The wall is essentially flat, inclined in relation to a longitudinal axis of the turbine engine, and includes a plurality of deflectors, each formed by an essentially rectangular flat sheet. The deflectors are mounted on the wall and each includes an aperture for the installation of a fuel injection system, a plurality of multi-perforation holes formed in relation to the deflectors around their aperture so as to allow a passage of air intended for the cooling of the deflectors, and a flow forcing unit which forces the flow of air for cooling the deflectors to flow radially around the fuel injection systems.

Abstract: A combustion chamber having a chamber end wall that presents a plurality of air and fuel injector devices, each of the devices including a bowl and a deflector mounted on a main axis forming a heat shield disposed around the bowl which flares in the gas flow direction and possesses an annular portion, the interface between the bowl and the deflector being situated on this annular portion, at least a portion of the interface being situated towards the end of the annular portion that is downstream in the gas flow direction, such that an annular cavity is defined between the deflector and the downstream annular portion of the interface. First bowl holes are formed in the annular portion to open out facing the edge of the chamber end wall that is in contact with the deflector in order to sustain a flow of air from upstream to downstream in the annular cavity.

Abstract: A diffuser for a single-head annular combustion chamber of an airplane engine, the diffuser comprising a separator formed by a thin sheet connected by structural arms to inner and outer circularly-symmetrical walls of the diffuser, the diffuser angle for each diffusion stream defined by the separator lying in the range about 12° to about 13°.

Abstract: Device for guiding an element in an orifice in a wall of a turbomachine combustion chamber, including a ring and a bush, the ring being traversed axially by the element and including an external annular rim guided transversely in an internal annular channel of the bush, the ring and the bush delimiting around the element a cylindrical annular passage opening into the chamber, air circulation being provided in the ring and/or in the bush and distributed about their axis so as to establish an air circulation in the cylindrical passage from the outside of the combustion chamber toward the inside.

Abstract: this invention discloses and claims a pharmaceutical composition in liquid or semi-liquid form, which is self-emulsifying or self-microemulsifying in aqueous medium, for the oral administration of a pyrazole-3-carboxamide derivative, in which said derivative is dissolved in an amphiphilic mixture containing one or more lipid solvents and a nonionic hydrophilic surfactant.

Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: The invention relates to methods for separating mixture components such as reactor effluent components. In particular, the invention relates to the use of an extractive agent such as a hydrocarbon in an extractive distillation process to separate monomers such as a C4-C7 isoolefins such as isobutylene from mixtures such as reactor effluents including one or more hydrofluorocarbon(s) (HFC).

Abstract: The invention relates to an annular wall (10) intended to connect transversely longitudinal walls of an annular combustion chamber of a turbine engine. The wall (10) is essentially flat, inclined in relation to a longitudinal axis of the turbine engine, and comprises a plurality of deflectors (16), each formed by an essentially rectangular flat sheet. The deflectors are mounted on the wall and each comprise an aperture for the installation of a fuel injection system, a plurality of multi-perforation holes (18) formed in relation to the deflectors (16) around their aperture so as to allow a passage of air intended for the cooling of the deflectors, and means (20) to force the flow of air for cooling the deflectors to flow radially around the fuel injection systems.

Abstract: The invention relates to the field of combustion chambers for aviation turbomachines. It relates to a combustion chamber having a chamber end wall that presents a plurality of air and fuel injector devices, each of the devices comprising a bowl and a deflector mounted on a main axis forming a heat shield disposed around the bowl which flares in the gas flow direction and possesses an annular portion, the interface between the bowl and the deflector being situated on this annular portion, at least a portion of said interface being situated towards the end of the annular portion that is downstream in the gas flow direction, such that an annular cavity is defined between the deflector and the downstream annular portion of the interface. First bowl holes are formed in the annular portion to open out in register with the edge of the chamber end wall that is in contact with the deflector in order to sustain a flow of air from upstream to downstream in the annular cavity.

Abstract: Device (48) for guiding an element in an orifice in a wall of a turbomachine combustion chamber (10), comprising a ring (50) and a bush (52), the ring being traversed axially by the element and comprising an external annular rim (60) guided transversely in an internal annular channel (52) of the bush, the ring and the bush delimiting around the element a cylindrical annular passage (76) opening into the chamber, air circulation means being formed in the ring and/or in the bush and distributed about their axis so as to establish an air circulation in the cylindrical passage from the outside of the combustion chamber toward the inside.

Abstract: This invention discloses and claims a pharmaceutical composition in liquid or semi-liquid form, which is self-emulsifying or self-microemulsifying in aqueous medium, for the oral administration of a pyrazole-3-carboxamide derivative, in which said derivative is dissolved in an amphiphilic mixture containing one or more lipid solvents and a nonionic hydrophilic surfactant.

Abstract: A diffuser for a single-head annular combustion chamber of an airplane engine, the diffuser comprising a separator formed by a thin sheet connected by structural arms to inner and outer circularly-symmetrical walls of the diffuser, the diffuser angle for each diffusion stream defined by the separator lying in the range about 12° to about 13°.

Abstract: The pharmaceutical formulations according to the invention contain from 0.5 to 50% by weight of a cyclic quaternary ammonium compound and pharmaceutically appropriate excipients and are formulated by wet granulation, preferably with polysorbate 80.