Abstract: A turbomachine turbine nozzle extending around a central axis, including at least one radially outer shroud, at least one radially inner shroud, and at least one blade made of ceramic matrix composite material, distinct from the radially inner shroud and from the radially outer shroud, and extending radially between the radially inner shroud and the radially outer shroud, the blade being hollow and including a cavity opening at a radially inner end and at a radially outer end of the blade, the nozzle including at least one tubular mast arranged in the cavity of the blade and allowing routing the ventilation air passing through the cavity of the blade, the mast including a radially outer end attached to the radially outer shroud, and a radially inner end cooperating with a radial flange for positioning the radially inner shroud.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: A turbine comprises a casing, an outer metal shroud, an inner metal shroud and an annular distributor having a plurality of CMC ring sectors, each sector comprising a mast, an inner platform, an outer platform and at least one blade having a hollow profile that defines an inner housing, the inner and outer platforms each having an opening communicating with said inner housing, and the mast passing through said openings and the inner housing and being secured to said casing and connected to said annular sector. Each blade comprises at least one first radial shoulder projecting axially towards the inside of the blade, and each mast comprises at least one second shoulder projecting axially towards the outside of the mast configured to radially cooperate with a first shoulder and radially press the blade against the mast.

Abstract: The present invention relates generally to methods for selecting or designing a compound for modulating the aggregation of a Tau protein. The method comprising using computer-implemented molecular modelling means to compare the three-dimensional structure of a candidate compound with a three-dimensional structure of at least a part of the Tau protein comprising amino acids 315-378 and determine whether the candidate compound is able to simultaneously form non-covalent interactions with two or more of Leu315, Ser341, Glu342, Lys343, Phe346, Lys347, Val350, Ser352, Ile354, Lys369, Ile371, Glu372, Phe378 and Thr373. A candidate compound that is able to form said interactions is predicted to modulate the aggregation of the Tau protein or truncated form thereof.

Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of a acetylcholinesterase levels.

Abstract: A device for cooling a turbine shroud comprising at least one annular flange configured to be attached to an annular radial collar of a shroud support structure being arranged upstream, with respect to a circulation direction of an air flow, of the turbine shroud, and comprising at least one cooling air circulation channel, a diffuser configured to be attached to said annular radial collar downstream of the annular flange and comprising at least one intake channel in fluid communication with the circulation channel of the annular flange, and comprising an injection cavity comprising a plurality of injection holes and being configured to inject on a radially external face of the shroud, via the injection holes, the cooling air originating in the intake channel, and a particle filter arranged on an inlet section of the circulation channel of the annular flange, the particle filter comprising a plurality of openings.

Abstract: A vehicle immobilizer system comprised of at least one deployable, remotely actuated lift system. The lift system is transported by a movable frame which can be remotely operated. The movable frame suspends the lift system during transport. However, during the lifting operation, the lift system bears the weight of the vehicle, while the movable frame does not. As a result, the movable frame can be of lightweight construction while the lift system can be robust. The lift system supports a universal docking plate which is designed to contact the suspect vehicle and suspend it without damaging it.

Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.

Abstract: The invention relates to a turbine assembly comprising: a plurality of ring sectors forming a ring; a support structure comprising a shroud from which there project radial flanges which serve to hold latching tabs of each ring sector; a stator positioned downstream of said ring and comprising a blade provided with a radially outer platform and extending axially opposite said ring; an annular space being defined between the ring, the support structure and the platform, this annular space having passing through it a leakage air current, the assembly comprising a hollow ring which occupies said annular space and which is shaped so as to collect, channel and expel said leakage air current, more specifically to channel and expel it into the radially inner region of said annular space.

Abstract: The present invention provides a system for the study of tau protein aggregation in neuronal cells in vitro which can be used to screen agents for therapeutic effectiveness against aggregates of tau protein or fragments thereof.

Abstract: The invention relates to specific binding molecules, such as antibodies, directed to key epitopes of tau. The specific binding molecules of the invention find applications in diagnostics and therapeutics of tauopathies including Alzheimer's disease.

Abstract: A turbomachine turbine nozzle extending around a central axis, including at least one radially outer shroud, at least one radially inner shroud, and at least one blade made of ceramic matrix composite material, distinct from the radially inner shroud and from the radially outer shroud, and extending radially between the radially inner shroud and the radially outer shroud, the blade being hollow and including a cavity opening at a radially inner end and at a radially outer end of the blade, the nozzle including at least one tubular mast arranged in the cavity of the blade and allowing routing the ventilation air passing through the cavity of the blade, the mast including a radially outer end attached to the radially outer shroud, and a radially inner end cooperating with a radial flange for positioning the radially inner shroud.

Abstract: The present invention provides methods of treating COVID-19 in a subject using methylthioninium compounds.

Abstract: T he present invention provides methods of treating COV-ID-19 in a subject using methylthioninium compounds.

Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.

Abstract: The present invention provides methods of alleviating hypoxemia in a subject through oral administration of a methylthioninium compound.

Abstract: The invention relates to a turbine assembly comprising: a plurality of ring sectors forming a ring; a support structure comprising a shroud from which there project radial flanges which serve to hold latching tabs of each ring sector; a stator positioned downstream of said ring and comprising a blade provided with a radially outer platform and extending axially opposite said ring; an annular space being defined between the ring, the support structure and the platform, this annular space having passing through it a leakage air current, the assembly comprising a hollow ring which occupies said annular space and which is shaped so as to collect, channel and expel said leakage air current, more specifically to channel and expel it into the radially inner region of said annular space.

Abstract: The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's disease and rontotemporal dementias can be achieved, while maintaining a desirable clinical profile. Also provided are LMT-containing dosage units and other compositions.