Abstract: The technical field of the invention is that of needleless syringes used for intradermal, subcutaneous or intramuscular injections of active principle for therapeutic purposes. More particularly, the invention concerns a needleless syringe (10) comprising a propelling system, the active principle and an application guide (8), mainly characterised in that the propelling system consists of an impact wave generating device (3) and the active principle is arranged in at least a blind cavity (7) of the downstream surface (6) of a barrier (4) extended by the application guide (8). Thus, the active principle is expelled in the form of streamlined jets, driven at very high speed.

Abstract: The invention concerns the field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle (7) initially set between an injector (1, 10) comprising at least an injection nozzle, said injector being contacted with the skin, and a wall (8) mobile under the effect of a propelling system (9) pressurizing and expelling the active principle through the injector located at the syringe downstream end (2). In order to produce nozzles in a considerable injector thickness and to control the jet coherence distance, said injector (1, 10) comprises at least two elements (3, 4) whereof the contact surfaces (30, 40, 40?) are oriented towards the skin, at least a groove (31, 41, 41?) forming an injection nozzle in the assembly of said elements.

Abstract: The electrode comprises a) a layer (5) which conducts electricity for the supply or the collection of an electrical current traversing the electrode, and b) a consumable electrochemical interface layer (7). According to the invention, it comprises, in addition, an intermediate layer (6) made of a chemically inert and electrically resistant material. This layer can consist of a dispersion of fine particles of carbon in a polymer binder. Application in the preparation of electrodes with increased electrochemical capacity, for an ionophoresis device for the transdermal administration of drugs or a device for the electrocicatrization of wounds.

Abstract: The invention concerns the technical field of needleless syringes for injecting an active principle through the skin. More particularly, the invention concerns a needleless syringe provided with a piezoelectric crystal and a triggering device comprising a triggering member and impacting means and, on a triggering device particularly adapted to needleless syringes. The invention is mainly characterized in that the impacting means comprises a latch maintained under elastic stress by being blocked against a stop element and the triggering member is capable of moving the latch to release it, so that it is urged to strike the piezoelectric crystal. Then, the crystal produces an electric arc designed to initiate a pyrotechnic charge whereof the combustion gases will help to expel the active principle contained in the syringe.

Abstract: A miniature valve for filling the reservoir of an apparatus for the transdermal administration of a medicine including a) a substrate, b) a fuel charge arranged on the substrate opposite the passage to be opened through it, and c) an electric resistor placed in contact with the fuel charge so that the supply of this resistor with a predetermined electric energy ensures the combustion of the charge and the opening of the passage by local rupture of the substrate under the pressure of the fuel gases of the charge. The device is useful for filling a medicine reservoir for the transdermal administration medicine aided by inophoresis.

Abstract: A novel transdermal system for the percutaneous delivery of a hormone, including a carrier and an adhesive matrix, is disclosed. The matrix includes (a) 20-50 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer, (b) 30-60 parts by weight of a tackifyier resin, (c) 4-25 parts by weight of propylene glycol laurate, (d) 2-10 parts by weight of a compound selected from N-alkyl-2-pyrrolidones, wherein the alkyl group is a C.sub.4-- C.sub.15 group, (e) 0.01-2 parts by weight of a stabilizing agent, (f) 0.1-12 parts by weight of at least one hormone selected from the group consisting of oestrogenic and progestogenic components, and (g) 1-12 parts by weight of a vinyl acetate/N-vinyl-2-pyrrolidone copolymer. A method for preparing said system and the therapeutical use thereof are also disclosed.

Abstract: This invention is concerned with a new transdermal matrix system for the percutaneous administration of a hormone, said matrix system, which has a support and a self-adhesive matrix, comprising a matrix containing:(a) 20 to 42 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer,(b) 35 to 55 parts by weight of a tackifying resin.(c) 5 to 25 parts by weight of a plasticizing agent selected from the group consisting of oleic alcohol, peglicol 5-oleate, propyleneglycol laurate or a polypropoxyl ether of cetyl alcohol,(d) 5 to 15 parts by weight of at least one compound selected from the group consisting of:crotamiton, andN-substituted 2-pyrrolidones of formula I, ##STR1## wherein R represents a (C.sub.1 -C.sub.15)-alkyl, cyclohexyl or 2-hydroxyethyl group,(e) 0,01 to 1 part by weight of a stabilizing agent and,(f) 0,1 to 5 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof.

Abstract: The device comprises a switched-mode power supply (1) equipped with an electronic switching member (T.sub.1), the closing of which controls the power supply to an inductor (L.sub.1) which discharges, when the member reopens, into a capacitor (C.sub.1) at the terminals of which the output voltage of the device appears, characterized in that it comprises (a) storage means for recording a sequence of image numbers of successive segments of the predetermined waveform, (b) a clocked digital counter (2) and (c) means (3) for successively loading this counter (2) with each of the numbers of this sequence considered as a bound of the count performed by the counter (2), the latter cyclically controlling the closing of the switching member (T.sub.1) for a predetermined time interval, each time the count performed reaches the limit thus fixed.

Abstract: The device comprises a switched-mode power supply (1) equipped with an electronic switching member (T.sub.1), the closing of which controls the power supply to an inductor (L.sub.1) which discharges, when the member reopens, into a capacitor (C.sub.1) at the terminals of which the output voltage of the device appears, characterized in that it comprises (a) storage means for recording a sequence of image numbers of successive segments of the predetermined waveform, (b) a clocked digital counter (2) and (c) means (3) for successively loading this counter (2) with each of the numbers of this sequence considered as a bound of the count performed by the counter (2), the latter cyclically controlling the closing of the switching member (T.sub.1) for a predetermined time interval, each time the count performed reaches the limit thus fixed.