Patents by Inventor Claude Nofre

Claude Nofre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5997933
    Abstract: The present invention has as subject compounds of formula: ##STR1## in which Y is C.sub.2 H.sub.5, (CH.sub.3).sub.2 CH or (R) CH(OH)CH.sub.3, and R" is (S) CH(C.sub.2 H.sub.5)C.sub.6 H.sub.5, (S) CH(CH.sub.3)C.sub.6 H.sub.5 or (R) CH(CH.sub.2 OCH.sub.3)C.sub.6 H.sub.5. These compounds are useful as sweetening agents.
    Type: Grant
    Filed: November 28, 1997
    Date of Patent: December 7, 1999
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5777159
    Abstract: The present invention has as subject compounds of formula: ##STR1## in which Y is C.sub.2 H.sub.5, (CH.sub.3).sub.2 CH or (R) CH(OH)CH.sub.3, and R" is (S) CH(C.sub.2 H.sub.5)C.sub.6 H.sub.5, (S) CH(CH.sub.3)C.sub.6 H.sub.5 or (R) CH(CH.sub.2 OCH.sub.3)C.sub.6 H.sub.5. These compounds are useful as sweetening agents.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: July 7, 1998
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5773640
    Abstract: Novel sweetening compound characterized in that it is N-?N-(3,3-dimethylbutyl)-L-.alpha.-aspartyl!-L-hexahydrophenylalanine 1-methyl ester of formula: ##STR1## and its method of preparation characterized in that an aqueous/alcohol solution of pH 4.5-5 of aspartame and 3,3-dimethylbutyraldehyde at room temperature is treated with hydrogen at a pressure of 3 bars in the presence of a catalyst based on platinum such as platinum black and platinum oxide and in that the product formed is purified by precipitation and filtration after evaporation in vacuo of the alcohol part of the solvent.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: June 30, 1998
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5480668
    Abstract: Lower alkyl esters of compounds of the formula ##STR1## wherein Z is hydrogen or hydroxyl and R is a hydrocarbyl group optionally substituted by hydroxy and/or alkoxy group, are useful as sweetening agents.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: January 2, 1996
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5430182
    Abstract: The present invention relates to a novel sweetening agent and to its method of preparation. This novel sweetening agent is a 2-substituted acyl derivative of L-aspartic or L-glutamic acid and has the general formula ##STR1## R being an acyl group of the formula ##STR2## and R' being a group of the formula ##STR3## R.sub.1, R.sub.2, R.sub.3, X, Y and Z being variously defined. This novel sweetening agent is essentially characterized by a high sweetening potency and a high stability compatible with the conditions of industrial use, and is applied especially for sweetening soft drinks.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: July 4, 1995
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5374733
    Abstract: The present invention relates to a novel sweetening agent and to its method of preparation. This novel sweetening agent is a 2-substituted acyl derivative of L-aspartic or L-glutamic acid and has the general formula ##STR1## R being an acyl group of the formula ##STR2## and R' being a group of the formula ##STR3## R.sub.1, R.sub.2, R.sub.3, X, Y and Z being variously defined. This novel sweetening agent is essentially characterized by a high sweetening potency and a high stability compatible with the conditions of industrial use, and is applied especially for sweetening soft drinks.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: December 20, 1994
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5310908
    Abstract: The present invention relates to a novel sweetening agent and to its method of preparation. This novel sweetening agent is a 2-substituted acyl derivative of L-aspartic or L-glutamic acid and has the general formula ##STR1## R being an acyl group of the formula ##STR2## and R' being a group of the formula ##STR3## R.sub.1, R.sub.2, R.sub.3, X, Y and Z being variously defined. This novel sweetening agent is essentially characterized by a high sweetening potency and a high stability compatible with the conditions of industrial use, and is applied especially for sweetening soft drinks.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: May 10, 1994
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5272272
    Abstract: The present invention relates to novel sweetening agents. These sweetening agents have the general formula ##STR1## in which R is a 5,6,7,8-tetrahydro-1-naphthoyl or 1-naphthoyl radical, R' is a 2-cyanopyrid-5-yl radical and n is equal to 2. These novel sweetening agents are characterized by an extremely high sweetening potency and a very high stability compatible with all the conditions of industrial use.
    Type: Grant
    Filed: April 21, 1992
    Date of Patent: December 21, 1993
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 5196540
    Abstract: The present invention relates to a novel sweetening agent and to its method of preparation. This novel sweetening agent is a 2-substituted acyl derivative of L-aspartic or L-glutamic acid and has the general formula ##STR1## R being an acyl group of the formula ##STR2## and R' being a group of the formula ##STR3## R.sub.1, R.sub.2, R.sub.3, X, Y and Z being variously defined. This novel sweetening agent is essentially characterized by a high sweetening potency and a high stability compatible with the conditions of industrial use, and is applied especially for sweetening soft drinks.
    Type: Grant
    Filed: October 23, 1990
    Date of Patent: March 23, 1993
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 4997667
    Abstract: Sweetening agents of the formula: ##STR1## wherein R is an heterocyclic group which, in a preferred embodiment, is a 2-cyanopyrid-5-yl or 2-cyanopyrimidin-5-yl group, A is O, NH or NCN, NH being able to be satisfied in hydrochloride form, n is 1 or 2 and B is COOH or a sodium, potassium, ammonium, calcium or magnesium salt.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: March 5, 1991
    Assignee: Universite Claude Bernard
    Inventors: Claude Nofre, Jean M. Tinti, Farroudja O. Chatzopoulos
  • Patent number: 4935517
    Abstract: Sweetening agents of the general formula: ##STR1## wherein R is a saturated or unsaturated, acyclic, cyclic or mixed hydrocarbon group having 5 to 13 carbon atoms, wherein R' is, in a preferred embodiment, a 4-cyanophenyl or 2-cyanopyrid-5-yl group, and wherein n is equal to 1 or 2.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: June 19, 1990
    Assignee: Universite Claude Bernard
    Inventors: Claude Nofre, Jean M. Tinti
  • Patent number: 4921939
    Abstract: Substituted guanidines and ethanamidines are provided as high potency sweetening agents.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: May 1, 1990
    Assignee: Universite Claude Bernard -Lyon 1
    Inventors: Claude Nofre, Jean M. Tinti, Farroudja Ouar Chatzopoulos
  • Patent number: 4877895
    Abstract: Sweetening agents, characterized in that they conform to the following formula: ##STR1## wherein: A is an imino (.dbd.N--), iminium (.dbd.N.sup.+ <), methylene (.dbd.C<) group, the iminium group being able to be salified by a physiologically acceptable anion;m and n are number equal to 1 or 2;B:when n=1, represents H, CN, OCH.sub.3, NO.sub.2, SO.sub.2 R, SOR, SO.sub.2 NHR, SO.sub.2 NR.sub.2, wherein R is an alkyl, cycloalkyl or aryl group having up to 10 carbon atoms;when n=2, represents H, CN, OCH.sub.3 ;X:represents CN, NO.sub.2, when B is H, CN, OCH.sub.3 ;represents CN, NO.sub.2, COCH.sub.3, CHO, Cl, CF.sub.3, F, H, when B is NO.sub.2, SO.sub.2 R, SOR, SO.sub.2 NHR, SO.sub.2 NR.sub.2 ;M is a hydrogen atom or a physiologically acceptable organic or inorganic cation.
    Type: Grant
    Filed: March 4, 1986
    Date of Patent: October 31, 1989
    Assignee: Universite Claude Bernard - Lyon 1
    Inventors: Claude Nofre, Jean M. Tinti, Farroudja O. Chatzopoulos
  • Patent number: 4673582
    Abstract: Sweetening agents of general formula: ##STR1## wherein: X is a CN, COOC.sub.1 -C.sub.3 alkyl, COC.sub.1 -C.sub.3 alkyl, CONHC.sub.1 -C.sub.3 alkyl, SO.sub.2 C.sub.1 -C.sub.3 alkyl, SOC.sub.1 -C.sub.3 alkyl, SO.sub.2 NHC.sub.1 -C.sub.3 alkyl, NO.sub.2, F, Cl substituent;n is a number equal to 0 or 1;M is a hydrogen atom, or an organic or inorganic physiologically acceptable cation;Y is a COOC.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl, CH.sub.2 OH, CHOHCH.sub.3, CF.sub.3 substituent;Z is a C.sub.1 -C.sub.5 n-alkyl, isobutyl, isopentyl, phenyl, cyclohexyl, benzyl, cyclohexylmethyl, CH.sub.2 C.sub.6 H.sub.4 OH(p), CH.sub.2 OC.sub.1 -C.sub.4 alkyl, CH.sub.2 COOC.sub.1 -C.sub.4 alkyl, CH.sub.2 SC.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.sub.2 SCH.sub.3, CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3, COOC.sub.1 -C.sub.4 alkyl, COOC.sub.3 -C.sub.7 cycloalkyl, CONHC.sub.2 -C.sub.4 alkyl, CONHC.sub.3 -C.sub.7 cycloalkyl, CONHC.sub.3 -C.sub.7 thiacycloalkyl, or CONHCH.sub.2 COOCH.sub.3 group;characterized in that A is an N--CN group.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: June 16, 1987
    Assignee: Universite Claude Bernard/Lyon 1
    Inventors: Claude Nofre, Jean M. Tinti
  • Patent number: 4645678
    Abstract: Compounds of the formula: ##STR1## in which: X represents at least one lone-electron pair donor group;A represents an oxygen or a sulfur atom, or an optionally substituted imino or methylene group;R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms;n represents a number equal to zero or to one;B represents a COOH or COOM group (M designating a cation);Y represents either a lone-electron pair donor group, or an alkyl group R' of 1 to 4 carbon atoms;Z representseither an optionally substituted hydrophobic group R", R" designating an alkyl, cycloalkyl or aryl group of 1 to 12 carbon atoms;or a lone-electron pair donor group on which a hydrophobic group R" is fixed;are useful as sweetening agents.
    Type: Grant
    Filed: September 15, 1983
    Date of Patent: February 24, 1987
    Assignee: Universite Claude Bernard - Lyon 1
    Inventors: Claude Nofre, Jean-Marie Tinti