Patents by Inventor Claude Roche

Claude Roche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050105669
    Abstract: An electromagnetic induction detector (9) is used to check the weld (6) of a plug (3) to a nuclear fuel cladding (2) still containing a spring (5). A weld made using an excessive energy weakens the metallurgical structure of the spring (5) which may reduce the electromagnetic coupling and the signal recorded by the detector (9). A comparison between the peak values of the signal and the plateau value of the signal gives a criterion for estimating the quality of the fuel rods (1).
    Type: Application
    Filed: February 6, 2003
    Publication date: May 19, 2005
    Applicant: Compagnie Generale des Matieres Nucleaires
    Inventors: Claude Roche, Fabrice Pavanello
  • Patent number: 6251858
    Abstract: The invention relates to compounds comprising one or several oligosides, each of said oligosides being fixed in a covalent manner on one or many molecules, matrixs or particles, specifically one, two or three, via an intermediary molecule possessing a nitrogen atom carried by a carbon in &agr; of a C═O group and one or many functional groups, specifically one, two or three, the covalent bond between said intermediary molecule and the oligoside being done by the intermediary of said nitrogen atom, and the covalent bond between said intermediary molecule and said molecule, said matrix, said particle, or said molecules, said matrixs, said particles being done by the intermediary of the said functional groups of said intermediary molecule and appropriate functional groups to the molecule(s), the matrix(ces) or the particle(s).
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: June 26, 2001
    Assignee: I.D.M. Immuno-Designed Molecules
    Inventors: Michel Monsigny, Annie-Claude Roche, Nadia Sdiqui, Roger Mayer
  • Patent number: 5733762
    Abstract: A compound consisting essentially of polylysine conjugated to non-charged residues and recognition signals wherein the free amino functions of said polylysine are substituted with non-charged residues and said recognition signals, which non-charged residues consist of gluconalactone and which recognition signals are at least one member of the group consisting of galactoside, mannoside, fucoside, Lewis.sup.x, Lewis.sup.b, oligomannoside, oligolactosamine saccharides and peptide ANP and said conjugated polylysine contains at least 30% unsubstituted free amino functions and a method of transfecting cultured cells.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: March 31, 1998
    Assignee: I.D.M. Immuno-Designed Molecules
    Inventors: Patrick Midoux, Patrick Erbacher, Annie-Claude Roche-Degremont, Michel Monsigny
  • Patent number: 5595897
    Abstract: The invention concerns a complex between at least one negatively charged nucleic acid and at least one positively charged polymeric conjugate, the link between the nucleic acid and the polymeric conjugate being electrostatic in nature, the polymeric conjugate containing a polymer formed from monomer components having free NH.sub.3.sup.+ functions of the aforementioned components and being as follows:--the free NH.sub.3.sup.+ functions from the aforementioned components are substituted in a ratio of at least 10%, advantageously from 45% to 70%, particularly 60%, by noncharged residues leading to a reduction of positive charges in comparison to the same nonsubstituted polymeric conjugate, facilitating the release of nucleic acid by the dissociation of the complex,--the aforementioned residues possess in addition the following properties:.fwdarw.they contain at least one hydroxyl group,.fwdarw.they do not correspond to a recognition signal recognized by a cellular membrane receptor,--the free NH.sub.3.sup.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: January 21, 1997
    Assignee: I.D.M. Immuno-Designed Molecules
    Inventors: Patrick Midoux, Patrick Erbacher, Annie-Claude Roche-Degremont, Michel Monsigny
  • Patent number: 4801578
    Abstract: Macromolecular conjugates of muramylpeptides useful as a stimulant of the cellular immune systems have the formula (R--X).sub.m --(LAM) wherein R is an N-acetylmuramylpeptidyl group or a derivative thereof; (LAM) is a neoglycoprotein having affinity for macrophages or monocytes, consisting of a protein covalently substituted by more than five glycidic chains, each having at least five osidic units, X is a covalent bond between a functional group of the peptidic part of R and a functional group of (LAM) or X is the residue of a conventional bifunctional coupling agent capable of bonding to R and (LAM) by formation of covalent bonds; and m is a number greater than or equal to 1.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: January 31, 1989
    Assignee: Establishment Public dit Centre National de la Recherche Scientifique (CNRS)
    Inventors: Michel Monsigny, Annie-Claude Roche