Patents by Inventor Claude Ropars

Claude Ropars has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5589389
    Abstract: An apparatus for incorporating one or more biologically active substances into red blood corpuscles (erythrocytes) by lysis and resealing technique comprises a washing unit, a lysis unit and a resealing unit. The washing unit obtains a suspension of erythrocytes from complete or incomplete blood. The lysis unit cools the erythrocyte suspension to a temperature below 10.degree. C. and maintains this temperature while the suspension is processed through a dialysis unit and subsequently exposed to the active substance. The treated erythrocyte suspension is held in a retardation pouch for a predetermined time and thereafter fed to the resealing unit, which heats the treated suspension to a temperature higher than 20.degree. C. and maintains this temperature while the treated suspension is exposed to the resealing product. The suspension exposed to the resealing product is collected in a collecting pouch for a predetermine period before it is discharged to the washing unit.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: December 31, 1996
    Assignee: Fondation Nationale de Transfusion Sanguine
    Inventors: Etienne Pages, Claude Ropars, Christophe Bailleul
  • Patent number: 4752586
    Abstract: This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at least one dialysis element is continuously supplied with an aqueous suspension of erythrocytes, the secondary compartment of the dialysis element contains an aqueous solution which is hypotonic with respect to the erythrocyte suspension in order to lyse the erythrocytes, the erythrocyte lysate is in contact with said substance having a biological activity and, in order to reseal the membrane of the erythrocytes, the osmotic and/or oncotic pressure of the erythrocyte lysate is increased after it has been brought into contact with said substance having a biological activity.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: June 21, 1988
    Assignees: Centre National de la Recherche Scientifique, Centre Hospitalier Regional de Tours, Studiengesellschaft Kohle mbH
    Inventors: Claude Ropars, Yves Nicolau, Maurice Chassaigne
  • Patent number: 4652449
    Abstract: This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at least one dialysis element is continuously supplied with an aqueous suspension of erythrocytes, the secondary compartment of the dialysis element contains an aqueous solution which is hypotonic with respect to the erythrocyte suspension in order to lyse the erythrocytes, the erythrocyte lysate is in contact with said substance having a biological activity and, in order to reseal the membrane of the erythrocytes, the osmotic and/or oncotic pressure of the erythrocyte lysate is increased after it has been brought into contact with said substance having a biological activity.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: March 24, 1987
    Assignees: Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Regional de Tours, Studiengesellschaft Kohle MBH
    Inventors: Claude Ropars, Yves C. Nicolau, Maurice Chassaigne