Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C1–C7, alkyl group, a cycloalkyl group, a heterocycle, a C2–C7 alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group, or R1 and R2, taken together, represent a C2–C7 alkylene which may contain one or more hetero atoms, and the group R3 represents a primary, secondary or tertiary amine, or pharmaceutically acceptable salts thereof, to manufacture a medicinal product with cicatrizing action, the said medicinal product being in a pharmaceutical form for topical use.

Abstract: The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom.

Abstract: The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form =0, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2) alkoxy group, R6-11 , (C1-C12) alkyl, (CH2)nNR7R8, or —(CH2)nN?R7R8R9 where n?1 to 12 Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.

Abstract: The present invention relates to the use of biguanide derivatives of general, formula I below; 1

Abstract: Novel galanthamine derivatives of general fonnulae (Ia) and (Ib), a method for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as cholinesterase inhibitors, are disclosed.

Abstract: Guanidine derivatives are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies. The compounds have the formula: ##STR1## wherein R.sub.1 is an isopropyl radical, a benzyl radical which is optionally substituted by one or more (C.sub.1 -C.sub.6)alkoxy radicals or a radical: ##STR2## R.sub.2, R.sub.3 and R.sub.

Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.

Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.

Abstract: Compounds are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies having formula I ##STR1## wherein R.sub.2, R.sub.3 and R.sub.4 together with the nitrogen atoms to which they are attached forms a heterocyclic ring.

Abstract: The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.

Abstract: Compositions and method of treating neuropathies resulting from diabetic, non-diabetic, toxic or viral origin and insuring regeneration of damaged nerve fibers by administration of the N,N-dimethyl-biguanide salt of p-chlorophenoxy-acetic acid.

Abstract: Pentacyclic derivatives of the general formula ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow are useful as cerebral protectors and vasodilators.

Abstract: New compounds having the formula ##STR1## in which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula : ##STR2## in which R is H or C.sub.2 H.sub.5.

Abstract: New compounds having the formula ##SPC1##In which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula: ##SPC2##In which R is H or C.sub.2 H.sub.5.

Abstract: The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom, R2=a hydroxy group, R1 and R2 together form ?O, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2)alkoxy group, R6?H, (C1-C12)alkyl, (CH2)nNR7R8, or —(CH2)nN+R7R8R9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.