Abstract: This invention provides a method of treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant neoplasms in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal. In particular, rapamycin is useful in treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant mammary and skin carcinomas, and central nervous system neoplasms.

Abstract: Methods of using rapamycin in the treatment of cancers or tumors are disclosed.

Abstract: Methods for using rapamycin in the treatment of certain cancers or tumors are disclosed.

Abstract: There is disclosed a mold assembly for casting a concrete wall having an opening and for anchoring a flexible resilient ring-like gasket in the peripheral wall of said opening to make a seal with a pipe passing through the opening. The assembly includes a pair of spaced mold walls for receiving unset concrete therebetween, a flexible resilient annular mold arranged to extend between the mold walls with its end surfaces in respective sealing contact with the inner surfaces of the mold walls and a rigid mold-supporting member removably inserted within the annular mold to support the latter while concrete is cast about the annular mold and between the mold walls. The outer surface of the annular mold has a continuous annular groove, intermediate the end surfaces, to receive the pipe-engaging portion of the gasket. Once the concrete is set, the outer anchoring portion of the gasket is embedded in the concrete.

Abstract: Antibiotic AY24,668 is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. AY24,668 has antifungal properties. Methods for its preparation and use are disclosed.

Abstract: Ravidomycin is produced by culturing Streptomyces ravidus NRRL 11,300 in an aqueous nutrient medium. Ravidomycin is useful as an antibacterial and antitumor agent. Methods for its preparation and use are disclosed.

Abstract: Ravidomycin is produced by culturing Streptomyces ravidus NRRL 11,300 in an aqueous nutrient medium. Ravidomycin is useful as an antibacterial agent. Methods for its preparation and use are disclosed.

Abstract: Naphthyridinomycin complex, a major component thereof called naphthyridinomycin A and a minor component thereof called naphthyridinomycin B are disclosed. These antibiotic substances exhibit antibacterial activity. The substances are producible by culturing a microorganism of the species Streptomyces in an aqueous nutrient medium under submerged aerobic fermentation conditions. Methods for their preparation and use are included.

Abstract: Antibiotic rapamycin is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. Rapamycin has antifungal properties. Methods for its preparation and use are disclosed.

Abstract: A new antibiotic complex, complex 484, components 484-A and 484-B thereof and a process for their preparation are disclosed. These antibiotic substances are producible by culturing a microorganism of the species Streptomyces in an aqueous nutrient medium under submerged aerobic fermentation conditions. The substances are useful against a broad spectrum of pathogenic bacteria. Methods for their use are disclosed also.