Abstract: The instant invention provides a process for reducing the drying time of softgel capsules by incorporating drying accelerators based on organic sulfonic acids and salts thereof into the formulations used to make the capsules.

Abstract: A softgel capsule having incorporated within said capsule: (i) an active pharmaceutical ingredient in a liquid carrier exhibiting release profiles selected from the group consisting of immediate release, extended release and combinations thereof; and (ii) one or more smaller capsules or smaller solid dosage forms wherein said smaller capsules or smaller solid dosage forms have active ingredients that are compatible or not compatible with each other or with another active within the softgel capsule and wherein said smaller capsules or smaller solid dosage forms exhibit release profiles selected from the group consisting of extended release, and immediate release and combinations thereof.

Abstract: The dissolution of Active Pharmaceutical Ingredients in polymeric melts plays an important role in the manufacturing of drugs that use polymers as excipients. The dissolution kinetics is essential for designing the processing equipment, describing the operating conditions, and defining material properties, for example, the appropriate API-polymer(s) pair. In one embodiment of the invention, the solubility of ketoprofen (KTO) in Soluplus®, Kollidon® VA64, Kollidon® SR and a combination of three; was analyzed under Hot Melt Extrusion (HME) processing conditions. Thermal characterization techniques show that a single phase amorphous solid solution (only one Tg) was achieved by HME at 120° C. and 70 rpm. The sample's stability was analyzed for 4 weeks and the single phase amorphous solid solution was maintained during that time. An extended release profile of KTO was achieved, releasing 100% of KTO in 12 h. The invention is particularly useful to target a specific release profile.