Abstract: The present invention relates to a method for producing a cured composition, which has at least one oxazolidinone ring and at least one isocyanurate ring and is crosslinked thereby, starting from a liquid reaction mixture comprising: (a) at least one liquid, aromatic epoxy resin; (b) at least one liquid, aromatic polyisocyanate; and (c) a catalyst composition; relative to the at least one polyisocyanate, the at least one epoxy resin is used in amounts such that the molar equivalent ratio of epoxide groups to isocyanate groups is at least 0.4; and curing the reaction mixture to give a cured polymer composition comprising at least one oxazolidinone ring and at least one isocyanurate ring, and also to the cured compositions obtainable by these methods.

Abstract: The present invention provides a method of manufacturing an automatic dishwashing detergent product, said product being provided as a discrete dosage unit and comprising a continuous, non-aqueous gel phase, comprising manufacturing said gel phase by a method comprising free radical polymerisation of monomer(s) in a non-aqueous reaction mixture to form a polymeric builder; wherein said reaction mixture comprises: at least one non-ionic surfactant which is an optionally end-capped alcohol alkoxylate; and one or more monomers comprising acrylic acid and optionally one or more further ?,?-ethylenically unsaturated acids, wherein no more than 0.1 wt % of the total amount of the monomer(s) are crosslinking monomer(s).

Abstract: Systems and methods for controlling drilling operations are provided. The methods include performing a drilling operation using a bottomhole assembly having a disintegrating device located at an end of a drill string. Detecting and monitoring formation layer orientations with one or more sensors is performed to obtain formation layer orientation information indicative of a formation layer orientation. Monitoring of a drilling operational performance of at least one of the disintegrating device and the bottomhole assembly is performed. A change in the drilling operational performance is detected and adjustment of a steering command is performed to set an angle of attack by the disintegrating device to the formation layer orientation based on the formation layer orientation information.

Abstract: Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.

Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Abstract: The invention relates to new bispecific antigen binding molecules, comprising at least one antigen binding domain capable of specific binding to 4-1BB, at least one moiety capable of specific binding to a target cell antigen, and a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

Abstract: A web server operating in a container has resource and network limits applied to add an extra layer of security to the web server. If a monitor detects that the container's resource usage is approaching one or more of these limits, which may be indicative of a DDoS attack, (step 210) or identifies traffic sources exhibiting suspicious behaviour, such as frequently repeated requests from the same address, or from a related set of addresses, a restrictor function caps the resources allowed by the original Webserver container to allow it to recover from buffer overflow and protect servers running in other containers from overwhelming any shared resources. A duplicator function starts up replica containers with the same resource limits to take overflow traffic, and a load balancing function then directs incoming traffic to these overflow containers etc.

Abstract: Decorative molded part with a support, on the front side facing a visible side of the decorative molded part of which a first and a second decorative layer are arranged side by side, the first decorative layer being applied to the support as a continuous layer and the second decorative layer being applied to the first decorative layer. A decorative molded part of the type mentioned above with a special aesthetic appearance is provided by the fact that the second decorative layer is made of a wood veneer and the first decorative layer is made of a metal foil and that the second decorative layer is pressed into the first decorative layer.

Abstract: Systems and methods for controlling subsurface drilling operations are described. The methods include performing the subsurface drilling operation using a bottomhole assembly having a disintegrating device, detecting, with a sensor, a formation layer orientation, approaching, with the disintegrating device, a rock layer, and generating a steering command to change an angle of attack of the disintegrating device relative to the rock layer based on the detected formation layer orientation.

Abstract: In some examples, a computer-implemented method of providing a calendar view interface in a client device includes receiving a request for a calendar view interface from the client device, determining a period of time to be presented in the calendar view interface, generating a calendar view interface for the period of time including an indicator for each day of the time period, retrieving snapshot information for the period of time, and generating a snapshot indicator for each day within the time period based on the snapshot information.

Abstract: Aspects of the disclosure relate to systems and methods for enhancing plant performance by identifying and manipulating the expression of plant genes involved in UV-B mediated improvements to hardiness and growth. Some aspects of the disclosure relate to systems and methods for identifying plant novel genes responsive to light stimulation. Some aspects of the disclosure relate to systems and methods for identifying transgenic plants improved so as to present desired agronomic traits associated with UV-B light stimulation. Some aspects of the disclosure relate to systems and methods for modulating plant sensitivity to light for enhancing plant performance or a desired agronomic trait. Some aspects of the disclosure relate to systems and methods for generating stable transgenic plants that exhibit a desired agronomic trait.

Abstract: The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct and a kit comprising the antibody construct.

Abstract: For multi-dimensional high-resolution imaging a structure marked with fluorescence markers, fluorescence enabling light is focused to illuminate a measurement area in a sample. A partial area of the measurement area is subjected to fluorescence inhibiting light. The partial area omits a center of the measurement area in that an intensity distribution of the fluorescence inhibiting light comprises a line-shaped intensity minimum. A minimal extension of the intensity minimum in a direction through the center area is by a factor k?2 smaller than a diameter of the measurement area in said direction. Without spatial resolution, fluorescence light emitted out of the measurement area is measured for a plurality of consecutive angle positions of the intensity minimum about the center, while the measurement area, for each angle position, is subjected to the fluorescence enabling light. A value of the measured fluorescence light is assigned to the position of the center.

Abstract: In an embodiment, a technique for identifying a target for a pointing device in a display. The technique may involve identifying a trajectory of movement of the pointing device and identifying the target for the pointing device based on at least the identified trajectory. The target may be, for example, a graphical user interface (GUI) element that may be displayed in the display or a location in the display.

Abstract: The present invention is directed to a polypropylene composition (C) comprising a polypropylene matrix, a dispersed phase comprising two different elastomeric ethylene copolymers and an inorganic filler. The present invention is further directed to an article comprising said polypropylene composition (C).

Abstract: Containerised computing processes are generated by an orchestration processor interpreting user commands and user profile data to build a deployment specification specifying functions to be run by a containerised process, using a shell script run on a host virtualisation container. External events such as security threats and computing resource overloads can be used to generate the virtualised process, allowing vulnerability detection, and apply countermeasures such as deployment or migration of containers during attacks to lesser prone infrastructure, and allows the orchestration of non-container tools to provide security and resilience.

Abstract: The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use.

Abstract: A composite material with enhanced electrical conductivity. The composite material includes two distinct phases. The first distinct phase is an excluded volume phase that includes an electrical insulator. The second distinct phase, a conductor phase, is a composite including an electrically insulating matrix and an embedded conductor phase that has sufficient concentration to exceed a percolation threshold within the conductor phase.

Abstract: Methods for handling traffic between a first network including a virtual communication platform and a second network, such as a circuit-switched network, include inserting customer identifiers into data packets. For traffic sent to the second network, the packets with the identifiers are transmitted to a trunking service that uses the identifier to determine one or more applicable service attributes for handling the data contained within the packets. For data traffic received from the second network, the virtual communication platform uses the identifiers to determine a destination, such as an endpoint device, for the traffic within the first network.