Patents by Inventor Claudia Cabella
Claudia Cabella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10583209Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.Type: GrantFiled: March 25, 2019Date of Patent: March 10, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Mathilde H. Lerche, Pernille Rose Jensen, Magnus Karlsson, Roberta Napolitano, Claudia Cabella, Luigi Miragoli, Sonia Colombo Serra, Fabio Tedoldi
-
Publication number: 20190275180Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.Type: ApplicationFiled: March 25, 2019Publication date: September 12, 2019Applicant: BRACCO IMAGING S.P.A.Inventors: Mathilde H. LERCHE, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
-
Patent number: 10265421Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.Type: GrantFiled: January 30, 2014Date of Patent: April 23, 2019Assignee: BRACCO IMAGING S.P.A.Inventors: Pernille Rose Jensen, Lerche H. Mathilde, Magnus Karlsson, Claudia Cabella, Sonia Colombo Serra, Luigi Miragoli, Luca Venturi, Fabio Tedoldi
-
Patent number: 10039843Abstract: The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.Type: GrantFiled: September 6, 2013Date of Patent: August 7, 2018Assignee: BRACCO IMAGING S.P.A.Inventors: Chiara Brioschi, Claudia Cabella, Simona Ghiani, Alessandro Maiocchi, Luigi Miragoli, Massimo Visigalli
-
Publication number: 20160296645Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.Type: ApplicationFiled: June 30, 2014Publication date: October 13, 2016Applicant: BRACCO IMAGING S.P.AInventors: Mathilde H. Lerche, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
-
Publication number: 20150374854Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.Type: ApplicationFiled: January 30, 2014Publication date: December 31, 2015Applicant: BRACCO IMAGING S.P.A.Inventors: Pernille Rose JENSEN, LERCHE H. Mathilde, Magnus KARLSSON, Claudia CABELLA, Sonia COLOMBO SERRA, Luigi MIRAGOLI, Luca VENTURI, Fabio TEDOLDI
-
Publication number: 20150273086Abstract: Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.Type: ApplicationFiled: October 24, 2013Publication date: October 1, 2015Applicant: BRACCO IMAGING S.P.A.Inventors: Claudia Cabella, Lara Caminiti, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Luigi Miragoli, Luisa Poggi, Fabio Tedoldi, Luca Venturi
-
Publication number: 20150258221Abstract: The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.Type: ApplicationFiled: September 6, 2013Publication date: September 17, 2015Applicant: BRACCO IMAGING S.P.A.Inventors: Chiara Brioschi, Claudia Cabella, Simona Ghiani, Alessandro Maiocchi, Luigi Miragoli, Massimo Visigalli
-
Patent number: 8961927Abstract: The invention provides MRI detectable species of formula (I) Dp-Sn-Nm??(I) wherein D is a MRI detectable moiety S is a spacer N is a molecule of a nutrient or pseudo-nutrient n is 0 or an integer m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.Type: GrantFiled: July 2, 2010Date of Patent: February 24, 2015Assignee: Bracco Imaging S.p.A.Inventors: Silvio Aime, Valentina Mainero, Simonetta Chirich Geninatti, Claudia Cabella
-
Publication number: 20100311962Abstract: The invention provides MRI detectable species of formula (I) Dp-Sn-Nm??(I) wherein D is a MRI detectable moiety S is a spacer N is a molecule of a nutrient or pseudo-nutrient n is 0 or an integer m is an integer and p is an integer. These compounds are useful for internalising into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalised in normal healthy cells thus allowing the diagnosis of tumors. The internalisation of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.Type: ApplicationFiled: July 2, 2010Publication date: December 9, 2010Inventors: Silvio AIME, Valentina MAINERO, Simonetta Chrich GENINATTI, Claudia CABELLA
-
Patent number: 7780952Abstract: The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer, m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.Type: GrantFiled: June 2, 2003Date of Patent: August 24, 2010Assignee: Bracco Imaging SpAInventors: Silvio Aime, Valentina Mainero, Simonetta Chirich Geninatti, Claudia Cabella
-
Publication number: 20050175543Abstract: The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer, m is an integer and p is an integer. These compounds are useful for internalising into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalised in normal healthy cells thus allowing the diagnosis of tumors. The internalisation of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.Type: ApplicationFiled: June 2, 2003Publication date: August 11, 2005Applicant: Bracco Imaging S.p.A.Inventors: Silvio Aime, Valentina Mainero, Simonetta Geninatti, Claudia Cabella