Patents by Inventor Claudia F. LUCCHINETTI

Claudia F. LUCCHINETTI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for producing imaging biomarkers indicative of a neurological disease state using gray matter suppressions via double inversion-recovery magnetic resonance imaging
    Patent number: 11219402
    Abstract: Systems and methods related to imaging biomarkers for determining neurological disease states of a subject are provided. In one embodiment, a method for producing an image indicative of a neurological disease using a magnetic resonance imaging (“MRI”) system is provided. The method includes directing the MRI system to perform a double inversion-recovery (“DIR”) pulse sequence to generate data where signals from gray matter and cerebral spinal fluid are substantially suppressed. The method also includes analyzing the DIR images, reconstructed from the acquired data, to identify cortical and white matter lesions. This includes identifying imaging biomarkers based on visual signatures of brain tissue, including white matter tissue. In some aspects, diffusion-weighted data may also be obtained using the MRI system.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: January 11, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John D. Port, Istvan Pirko, Jan-Mendelt Tillema, Yunhong Shu, Claudia F. Lucchinetti
  • SYSTEMS AND METHODS FOR PRODUCING IMAGING BIOMARKERS INDICATIVE OF A NEUROLOGICAL DISEASE STATE USING GRAY MATTER SUPPRESSIONS VIA DOUBLE INVERSION-RECOVERY MAGNETIC RESONANCE IMAGING
    Publication number: 20160220168
    Abstract: Systems and methods related to imaging biomarkers for determining neurological disease states of a subject are provided. In one embodiment, a method for producing an image indicative of a neurological disease using a magnetic resonance imaging (“MRI”) system is provided. The method includes directing the MRI system to perform a double inversion-recovery (“DIR”) pulse sequence to generate data where signals from gray matter and cerebral spinal fluid are substantially suppressed. The method also includes analyzing the DIR images, reconstructed from the acquired data, to identify cortical and white matter lesions. This includes identifying imaging biomarkers based on visual signatures of brain tissue, including white matter tissue. In some aspects, diffusion-weighted data may also be obtained using the MRI system.
    Type: Application
    Filed: September 22, 2014
    Publication date: August 4, 2016
    Inventors: John D. PORT, Istvan PIRKO, Jan-Mendelt TILLEMA, Yunhong SHU, Claudia F. LUCCHINETTI