Patents by Inventor Claudia Gässler-Dietsche

Claudia Gässler-Dietsche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of dehydrogenases with stable coenzymes
    Patent number: 11220674
    Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: January 11, 2022
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Carina Horn, Dieter Heindl, Claudia Gaessler-Dietsche, Joachim Hoenes
  • Enzyme stabilization in electrochemical sensors
    Patent number: 11078513
    Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 3, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Gregor Ocvirk, Claudia Gaessler-Dietsche
  • Stable NAD/NADH derivatives
    Patent number: 10167497
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: January 1, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • Stabilization of Dehydrogenases with Stable Coenzymes
    Publication number: 20180265849
    Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.
    Type: Application
    Filed: January 11, 2018
    Publication date: September 20, 2018
    Inventors: Carina Horn, Dieter Heindl, Claudia Gaessler-Dietsche, Joachim Hoenes
  • ENZYME STABILIZATION IN ELECTROCHEMICAL SENSORS
    Publication number: 20180223323
    Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 9, 2018
    Inventors: Gregor OCVIRK, Claudia GAESSLER-DIETSCHE
  • Stabilization of dehydrogenases with stable coenzymes
    Patent number: 9896666
    Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: February 20, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Carina Horn, Dieter Heindl, Claudia Gaessler-Dietsche, Joachim Hoenes
  • Enzyme stabilization in electrochemical sensors
    Patent number: 9879298
    Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: January 30, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Gregor Ocvirk, Claudia Gaessler-Dietsche
  • STABLE NAD/NADH DERIVATIVES
    Publication number: 20160326567
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Application
    Filed: July 20, 2016
    Publication date: November 10, 2016
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • Stable NAD/NADH derivatives
    Patent number: 9399790
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Grant
    Filed: March 23, 2014
    Date of Patent: July 26, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • Fast reaction kinetics of enzymes having low activity in dry chemistry layers
    Patent number: 9359634
    Abstract: The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: June 7, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Claudia Gaessler-Dietsche, Dieter Heindl, Joachim Hoenes, Thomas Meier, Rainer Schmuck
  • HIGH EFFICIENCY METHODS OF PRODUCING BLOOD GLUCOSE TEST ELEMENTS, AS WELL METHODS OF USING THE SAME
    Publication number: 20160010141
    Abstract: Methods are provided for producing diagnostic test elements, where the diagnostic test elements include a stable analytical chemical reagent of a coenzyme-dependent enzyme and an artificial coenzyme. Diagnostic products including diagnostic test elements having the stable analytical chemical reagent also are provided.
    Type: Application
    Filed: August 20, 2015
    Publication date: January 14, 2016
    Applicant: ROCHE DIABETES CARE, INC.
    Inventors: Claudia Gaessler-Dietsche, Hans-Peter Haar, Carina Horn
  • ENZYME STABILIZATION IN ELECTROCHEMICAL SENSORS
    Publication number: 20150008141
    Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.
    Type: Application
    Filed: June 18, 2014
    Publication date: January 8, 2015
    Inventors: Gregor OCVIRK, Claudia GAESSLER-DIETSCHE
  • FAST REACTION KINETICS OF ENZYMES HAVING LOW ACTIVITY IN DRY CHEMISTRY LAYERS
    Publication number: 20140322737
    Abstract: The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
    Type: Application
    Filed: August 16, 2011
    Publication date: October 30, 2014
    Inventors: Carina Horn, Claudia Gaessler-Dietsche, Dieter Heindl, Joachim Hoenes, Thomas Meier, Rainer Schmuck
  • Stable NAD/NADH derivatives
    Patent number: 8809013
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: August 19, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • STABLE NAD/NADH DERIVATIVES
    Publication number: 20140206024
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Application
    Filed: March 23, 2014
    Publication date: July 24, 2014
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • Fluorescence spectroscopy in absorbing media
    Patent number: 8501113
    Abstract: The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement of a fluorophore, wherein the detection medium which contains a fluorophore or a precursor of the fluorophore is admixed with an absorber whose absorbance spectrum superimposes the fluorescence excitation range of the fluorophore. The system consisting of the fluorophore and the absorber, which is produced in the detection medium, has an altered effective fluorescence excitation range with an altered fluorescence excitation maximum. Illumination with fluorescence excitation light can take place within the range of this altered excitation maximum. The measured signal obtained from determining fluorescence emission exhibits only low dependence on the wavelength of the excitation light.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: August 6, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Wolfgang Petrich, Claudia Gaessler-Dietsche, Carina Horn, Kai Hebestreit, Jean-Michel Asfour, Klemens Bardelang, Gerrit Kocherscheidt
  • Fluorescence spectropscopy in absorbing media
    Patent number: 8338118
    Abstract: The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement of a fluorophore, wherein the detection medium which contains a fluorophore or a precursor of the fluorophore is admixed with an absorber whose absorbance spectrum superimposes the fluorescence excitation range of the fluorophore. The system consisting of the fluorophore and the absorber, which is produced in the detection medium, has an altered effective fluorescence excitation range with an altered fluorescence excitation maximum. Illumination with fluorescence excitation light can take place within the range of this altered excitation maximum. The measured signal obtained from determining fluorescence emission exhibits only low dependence on the wavelength of the excitation light.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: December 25, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Wolfgang Petrich, Claudia Gaessler-Dietsche, Carina Horn, Kari Hebestreit, Jean-Michel Asfour, Klemens Bardelang, Gerrit Kocherscheidt
  • Integrated test element
    Patent number: 8242461
    Abstract: An integrated test element (110) is proposed for detecting for detecting at least one analyte in a sample (142), in particular in a liquid sample (142). The integrated test element (110) has a carrier element (112), with an application face (114) on which at least one organic electroluminescent component (126) is applied. Furthermore, at least one indicator substance (136) is applied on the application face (114), which indicator substance (136) alters at least one optical characteristic, in particular an emission characteristic (e.g. a fluorescence characteristic), when it comes into contact with the at least one analyte. Furthermore, the integrated test element (110) has at least one photodetector element (116).
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: August 14, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Bernd Rösicke, Kai Hebestreit, Claudia Gässler-Dietsche, Frederic Wehowski
  • ENZYME STABILIZATION IN ELECTROCHEMICAL SENSORS
    Publication number: 20120125789
    Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 24, 2012
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Gregor OCVIRK, Claudia GAESSLER-DIETSCHE
  • STABILIZATION OF DEHYDROGENASES WITH STABLE COENZYMES
    Publication number: 20110143416
    Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.
    Type: Application
    Filed: August 19, 2010
    Publication date: June 16, 2011
    Inventors: Carina Horn, Dieter Heindl, Claudia Gaessler-Dietsche, Joachim Hoenes