Abstract: The use of tapentadol for the manufacture of a medicament comprising at least one administration unit A containing dose a of tapentadol and at least one administration unit B containing dose b of tapentadol, where dose a<dose b, for the treatment of pain.

Abstract: A heat exchanger, in particular exhaust-gas cooler, is described herein. The heat exchanger includes tubes of unipartite form or formed from two plates. The tubes form a first and a second fluid duct, and the respective fluid ducts are arranged adjacent to one another. The first fluid duct is designed to be open at at least one of its ends for the inflow and/or outflow of a first fluid. The second fluid ducts are closed at an end side of the tubes by way of an inward or outward step. The step has a greater extent T in the tube longitudinal direction in the corner regions of the tube than between the corner regions. Several non-limiting descriptive embodiments are disclosed herein.

Abstract: The invention provides coated particles with a taste-masked drug substance. The particles comprise a core with the agglomerated active ingredient and a coating comprising a triglyceride and a surfactant. The particles exhibit rapid drug release and a stable release profile. Moreover, the invention provides a hot-melt coating method for manufacturing such particles, and pharmaceutical compositions comprising the particles. The method allows the coating of core particles at moderate temperatures, thereby preventing the degradation of the thermolabile active ingredient.

Abstract: The invention relates to a heat exchanger, in particular exhaust-gas cooler or charge-air cooler, comprising a plate stack composed of multiple elongate plate pairs, wherein in each case two interconnected plates form a first fluid duct between them, and a second fluid duct is formed between two plate pairs, wherein the plates of a plate pair are of U-shaped form with a bottom and upturned side walls and lie against one another so as to delimit the first flow duct, wherein one of the plates of a plate pair has, on its end side, a tab which serves for beading over around the end side of the other plate, wherein the tab on the bottom of the plate is beaded over, and the beading-over of the tab also continues into the side walls of the plates.

Abstract: The invention relates to a heat exchanger having a tube bundle with tubes as heat exchanger matrix, it being possible for the tubes to be flowed through by a first fluid and in this way defining a first fluid channel, and to be flowed around by a second fluid and in this way defining a second fluid channel, the tube bundle being configured so as to be closed off toward the outside, in order to close off the second fluid channel, or being arranged in a housing, in order to close off the second fluid channel, the tubes being configured so as to be open on the end side for the inflow or outflow of the first fluid.

Abstract: The invention provides coated particles with a taste-masked drug substance. The particles comprise a core with the agglomerated active ingredient and a coating comprising a triglyceride and a surfactant. The particles exhibit rapid drug release and a stable release profile. Moreover, the invention provides a hot-melt coating method for manufacturing such particles, and pharmaceutical compositions comprising the particles. The method allows the coating of core particles at moderate temperatures, thereby preventing the degradation of the thermolabile active ingredient.

Abstract: The invention relates to a heat exchanger having a tube bundle with tubes as heat exchanger matrix, it being possible for the tubes to be flowed through by a first fluid and in this way defining a first fluid channel, and to be flowed around by a second fluid and in this way defining a second fluid channel, the tube bundle being configured so as to be closed off toward the outside, in order to close off the second fluid channel, or being arranged in a housing, in order to close off the second fluid channel, the tubes being configured so as to be open on the end side for the inflow or outflow of the first fluid.

Abstract: The invention relates to a heat exchanger, in particular exhaust-gas cooler or charge-air cooler, comprising a plate stack composed of multiple elongate plate pairs, wherein in each case two interconnected plates form a first fluid duct between them, and a second fluid duct is formed between two plate pairs, wherein the plates of a plate pair are of U-shaped form with a bottom and upturned side walls and lie against one another so as to delimit the first flow duct, wherein one of the plates of a plate pair has, on its end side, a tab which serves for beading over around the end side of the other plate, wherein the tab on the bottom of the plate is beaded over, and the beading-over of the tab also continues into the side walls of the plates.

Abstract: The invention relates to a heat exchanger, in particular exhaust-gas cooler, having tubes of unipartite form or formed from two shell-like plates, which tubes form a first and a second fluid duct, wherein the respective fluid ducts are arranged adjacent to one another, wherein the first fluid duct is designed to be open at at least one of its ends for the inflow and/or outflow of the first fluid, wherein, at the ends, the tubes are, by way of an inward or outward step, designed such that the second fluid ducts are closed at the end side, wherein the step has a greater extent T in the tube longitudinal direction in the corner regions of the tube than between the corner regions.

Abstract: A heat exchanger for heat exchange between a first fluid and a second fluid is provided that includes: a block for guiding the first fluid and the second fluid separately and in a heat-exchanging manner, and a fluid connection for the first fluid. The block comprises a housing provided with a chamber through which the second fluid can flow, and a block end element for the fluid-tight separation of the chamber and the fluid connection. The housing can be provided for connecting the block to the fluid connection. The block end element is not used to connect the block to the fluid connection but rather preferably only the housing. The housing can be thickened accordingly in the region of the block connection. The fixing point for the block end element to the housing and the fixing point for the fluid connection to the housing are at a distance from each other.

Abstract: The present invention relates to the use of mesenchymal stromal cells (MSCs) for the treatment of supralethal radiation injury.

Abstract: The invention relates to mesenchymal stromal cells produced by culturing the cells in platelet lysate supplemented media and methods of using these cells to treat neurological and kidney associated disorders.

Abstract: The invention relates to a method for purifying mesenchymal stem cells, producing cells corresponding to prior art, the cells obtained being characterised by an increased proliferation capacity while maintaining the multipotency and typical antigen characteristics. To this end, mesenchymal stem cells that can be multiplied in a significantly improved manner compared to prior art are first provided and can also be differentiated, after a longer cultivation period, in three mesenchymal directions.

Abstract: The use of tapentadol for treating pain due to osteoarthritis.

Abstract: A heat exchanger for heat exchange between a first fluid and a second fluid is provided that includes: a block for guiding the first fluid and the second fluid separately and in a heat-exchanging manner, and a fluid connection for the first fluid. The block comprises a housing provided with a chamber through which the second fluid can flow, and a block end element for the fluid-tight separation of the chamber and the fluid connection. The housing can be provided for connecting the block to the fluid connection. The block end element is not used to connect the block to the fluid connection but rather preferably only the housing. The housing can be thickened accordingly in the region of the block connection. The fixing point for the block end element to the housing and the fixing point for the fluid connection to the housing are at a distance from each other.

Abstract: The invention relates to the production of retina-specific cells from human adult bone marrow stem cells by culturing bone marrow stem cells in the presence of a differentiation medium. The invention also relates to retina-specific cells and to the use of these cells for treating diseases associated with acquired or congenital dysfunction of the retinal pigment epithelium, cells of adjacent structures of the entire retina and of the choroid coat as well as of other eye tissue.

Abstract: A method of producing blood products in vitro and a method of treatment are provided. The methods include culturing isolated non-SV40 transformed mesenchymal stem cells with growth factors for a time sufficient to produce at least one type of blood products. A method of differentiating mesenchymal cells is also provided. The method of differentiating mesenchymal cells includes culturing isolated non-SV40 transformed mesenchymal stem cells in vitro with growth factors and producing at least one blood cell product.

Abstract: The invention relates to a heat exchanger, particularly in tube bundle-type, panel-type or plate-type design. The heat exchanger has a housing inside of which a number of flow channels are formed for a primary flow and a secondary medium, and the housing has a sandwich design.

Abstract: The invention relates to a method for purifying mesenchymal stem cells, producing cells corresponding to prior art, the cells obtained being characterised by an increased proliferation capacity while maintaining the multipotency and typical antigen characteristics. To this end, mesenchymal stem cells that can be multiplied in a significantly improved manner compared to prior art are first provided and can also be differentiated, after a longer cultivation period, in three mesenchymal directions.