Patents by Inventor Claudia Pacholski
Claudia Pacholski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9909985Abstract: A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest. Pores in a second layer of the micro-porous thin film structure are smaller than the pores in the top layer and are sized to accept a second molecule of interest that is smaller than the first molecule of interest. The pores in the second layer are too small to accept the first molecule of interest. The pores in the top layer and the pores in the second layer are sized and arranged such that light reflected from the multi-layer micro-porous thin film structure produces multiple superimposed interference patterns that can be resolved. In preferred embodiments, the multi-layer micro-porous thin film structure is a porous silicon thin film multi-layer structure formed on a silicon substrate, such as a silicon wafer. Specific and nonspecific binding can be detected with biosensors of the invention.Type: GrantFiled: January 7, 2010Date of Patent: March 6, 2018Assignee: The Regents of the University of CaliforniaInventors: Claudia Pacholski, Gordon M. Miskelly, Michael J. Sailor
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Patent number: 9469526Abstract: The invention relates to conical structures on substrate surfaces, in particular optical elements, to methods for the production thereof and to the use thereof, in particular in optical devices, solar cells and sensors. The conical nanostructures according to the invention are suitable in particular for providing substrate surfaces having very low light reflection.Type: GrantFiled: December 17, 2010Date of Patent: October 18, 2016Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Christoph Morhard, Claudia Pacholski, Joachim P. Spatz
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Patent number: 9169566Abstract: The invention relates to a method for spatially resolving the enlargement and fine adjustment of precious metal nanoparticles according to size on a substrate surface and to the nanoparticle arrangements and nanostructured substrate surfaces thereby produced and to the use thereof.Type: GrantFiled: November 15, 2010Date of Patent: October 27, 2015Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Christoph Morhard, Claudia Pacholski, Joachim P. Spatz
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Patent number: 9132445Abstract: The present invention relates to highly ordered arrays of nanoholes in metallic films and to an improved method for producing the same. The method according to the invention for producing an highly ordered array of nanoholes in metallic films on a substrate comprises the following steps: a) providing microspheres comprising poly-N-isopropylamide (polyNIPAM), the microspheres being selected from pure poly-N-isopropyl-amide (polyNIPAM) hydrogel microspheres and polymeric or inorganic beads carrying poly-N-isopropylamide (polyNIPAM) hydrogel chains, b) coating an aqueous dispersion of said microspheres onto a substrate and drying the dispersion, which results in a non-close packed ordered array of the microspheres, c) generating a metallic film on the substrate, d) removing the microspheres from the surface of the substrate which results in an ordered array of nanoholes on the substrate, and e) optionally increasing the thickness of the metallic film by selective electroless plating.Type: GrantFiled: March 5, 2009Date of Patent: September 15, 2015Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Claudia Pacholski, Stefan B. Quint
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Patent number: 9090987Abstract: The present invention relates to highly ordered arrays of colloidal 2D crystals on a substrate and to an improved method for producing the same. The method according to the invention for producing an highly ordered array of colloidal 2D crystals on a substrate comprises the following steps: a) providing a suspension of microspheres comprising poly-N-isopropylamide (polyNIPAM), the microspheres being selected from pure poly-N-isopropylamide (polyNIPAM) hydrogel microspheres, functionalized polyNIPAM microspheres, and polymeric or inorganic beads carrying poly-N-isopropyl-amide (polyNIPAM) hydrogel chains, in an aqueous medium on a substrate, wherein the aqueous medium comprises a mixture of water and a lower alkyl alcohol, b) subjecting the suspension deposited on the substrate after step a) to a shear force, and c) drying the suspension. In a preferred embodiment of the invention, the shear force is generated by applying a pulsed gas stream to the substrate surface.Type: GrantFiled: March 4, 2011Date of Patent: July 28, 2015Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.Inventors: Stefan B. Quint, Claudia Pacholski
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Publication number: 20130338303Abstract: The present invention relates to highly ordered arrays of colloidal 2D crystals on a substrate and to an improved method for producing the same. The method according to the invention for producing an highly ordered array of colloidal 2D crystals on a substrate comprises the following steps: a) providing a suspension of microspheres comprising poly-N-isopropylamide (polyNIPAM), the microspheres being selected from pure poly-N-isopropylamide (polyNIPAM) hydrogel microspheres, functionalized polyNIPAM microspheres, and polymeric or inorganic beads carrying poly-N-isopropyl-amide (polyNIPAM) hydrogel chains, in an aqueous medium on a substrate, wherein the aqueous medium comprises a mixture of water and a lower alkyl alcohol, b) subjecting the suspension deposited on the substrate after step a) to a shear force, and c) drying the suspension. In a preferred embodiment of the invention, the shear force is generated by applying a pulsed gas stream to the substrate surface.Type: ApplicationFiled: March 4, 2011Publication date: December 19, 2013Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissen.Inventors: Stefan B. Quint, Claudia Pacholski
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Publication number: 20130284690Abstract: The present invention relates to an improved process for producing highly ordered nanopillar or nanohole structures, in particular on large areas, which can be used as masters in NIL, hot embossing or injection molding processes. The process involves decorating a surface with an ordered array of metal nanoparticles produced by means of a micellar block- copolymer nano-lithography process; etching the primary substrate to a depth of 50 to 500 nm, where the nanoparticles act as a mask and an ordered array of nanopillars or nanocones corresponding to the positions of the nanoparticles is thus produced; using the nanostructured master or stamp in a structuring processes. Also the finished nanostructured substrate surface can be used as a sacrificial master which is coated with a continuous metal layer and the master is then etched away to leave a metal stamp having an ordered array of nanoholes which is a negative of the original array of nanopillars or nanocones.Type: ApplicationFiled: October 12, 2011Publication date: October 31, 2013Applicants: Max-Planck-Gesellschaft zur Foerderung der Wissens chaften e.V., FACHHOCHSCHULE JENAInventors: Christoph Morhard, Claudia Pacholski, Joachim P. Spatz, Robert Brunner
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Publication number: 20130236881Abstract: The invention relates to a method for producing column-shaped or conical nanostructures, wherein the substrate surface is covered with an arrangement of metal nanoparticles and etched, the nanoparticles acting as an etching mask and the etching parameters being set such that column structures or cone structures are created below the nanoparticles and the nanoparticles are preserved as a structural coating.Type: ApplicationFiled: May 30, 2011Publication date: September 12, 2013Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissensdchaften e.V.Inventors: Joachim P. Spatz, Claudia Pacholski, Tobias Schoen, Lindarti Purwaningsih, Tobias Wolfram
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Publication number: 20120268823Abstract: The invention relates to conical structures on substrate surfaces, in particular optical elements, to methods for the production thereof and to the use thereof, in particular in optical devices, solar cells and sensors. The conical nanostructures according to the invention are suitable in particular for providing substrate surfaces having very low light reflection.Type: ApplicationFiled: December 17, 2010Publication date: October 25, 2012Inventors: Christoph Morhard, Claudia Pacholski, Joachim P. Spatz
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Publication number: 20120244322Abstract: The invention relates to a method for spatially resolving the enlargement and fine adjustment of precious metal nanoparticles according to size on a substrate surface and to the nanoparticle arrangements and nanostructured substrate surfaces thereby produced and to the use thereof.Type: ApplicationFiled: November 15, 2010Publication date: September 27, 2012Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Christoph Morhard, Claudia Pacholski, Joachim P. Spatz
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Publication number: 20120028029Abstract: The present invention relates to highly ordered arrays of nanoholes in metallic films and to an improved method for producing the same. The method according to the invention for producing an highly ordered array of nanoholes in metallic films on a substrate comprises the following steps: a) providing microspheres comprising poly-N-isopropylamide (polyNIPAM), the microspheres being selected from pure poly-N-isopropyl-amide (polyNIPAM) hydrogel microspheres and polymeric or inorganic beads carrying poly-N-isopropylamide (polyNIPAM) hydrogel chains, b) coating an aqueous dispersion of said microspheres onto a substrate and drying the dispersion, which results in a non-close packed ordered array of the microspheres, c) generating a metallic film on the substrate, d) removing the microspheres from the surface of the substrate which results in an ordered array of nanoholes on the substrate, and e) optionally increasing the thickness of the metallic film by selective electroless plating.Type: ApplicationFiled: March 5, 2009Publication date: February 2, 2012Inventors: Claudia Pacholski, Stefan B. Quint
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Publication number: 20110170106Abstract: A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest. Pores in a second layer of the micro-porous thin film structure are smaller than the pores in the top layer and are sized to accept a second molecule of interest that is smaller than the first molecule of interest. The pores in the second layer are too small to accept the first molecule of interest. The pores in the top layer and the pores in the second layer are sized and arranged such that light reflected from the multi-layer micro-porous thin film structure produces multiple superimposed interference patterns that can be resolved. In preferred embodiments, the multi-layer micro-porous thin film structure is a porous silicon thin film multi-layer structure formed on a silicon substrate, such as a silicon wafer. Specific and nonspecific binding can be detected with biosensors of the invention.Type: ApplicationFiled: January 7, 2010Publication date: July 14, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Claudia Pacholski, Gordon M. Miskelly, Michael J. Sailor
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Patent number: 7759129Abstract: The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte A coating can also act as a protective layer in preferred embodiment. A thin substrate susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule.Type: GrantFiled: January 10, 2007Date of Patent: July 20, 2010Assignee: The Regents of the University of CaliforniaInventors: Michael J. Sailor, Manuel M. Orosco, Claudia Pacholski, Gordon M. Miskelly
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Publication number: 20090215191Abstract: The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte A coating can also act as a protective layer in preferred embodiment. A thin substrate susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule.Type: ApplicationFiled: January 10, 2007Publication date: August 27, 2009Inventors: Michael J. Sailor, Manuel M. Orosco, Claudia Pacholski, Gordon M. Miskelly
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Publication number: 20070108465Abstract: A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest. Pores in a second layer of the micro-porous thin film structure are smaller than the pores in the top layer and are sized to accept a second molecule of interest that is smaller than the first molecule of interest. The pores in the second layer are too small to accept the first molecule of interest. The pores in the top layer and the pores in the second layer are sized and arranged such that light reflected from the multi-layer micro-porous thin film structure produces multiple superimposed interference patterns that can be resolved. In preferred embodiments, the multi-layer micro-porous thin film structure is a porous silicon thin film multi-layer structure formed on a silicon substrate, such as a silicon wafer. Specific and nonspecific binding can be detected with biosensors of the invention.Type: ApplicationFiled: March 8, 2006Publication date: May 17, 2007Inventors: Claudia Pacholski, Gordon Miskelly, Michael Sailor