Patents by Inventor Claudia Piutti

Claudia Piutti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoxazolo-quinazolines as modulators of protein kinase activity
    Patent number: 9333205
    Abstract: The present invention relates to substituted isoxazolo-quinazolines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular human MPS1 and PERK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: May 10, 2016
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Marina Caldarelli, Italo Beria, Nicoletta Colombo, Claudia Piutti, Matteo Salsa, Gabriella Traquandi
  • Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
    Patent number: 9181258
    Abstract: The present invention relates to 4-alkyl substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives, of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: November 10, 2015
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Francesco Casuscelli, Alessandra Badari, Sten Christian Orrenius, Claudia Piutti, Teresa Disingrini
  • Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
    Patent number: 9145418
    Abstract: The present invention relates to substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives, of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 29, 2015
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Francesco Casuscelli, Elena Casale, Marisa Montemartini, Claudia Piutti
  • 4-ALKYL SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS
    Publication number: 20140249146
    Abstract: The present invention relates to 4-alkyl substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: October 4, 2012
    Publication date: September 4, 2014
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Francesco Casuscelli, Alessandra Badari, Sten Christian Orrenius, Claudia Piutti, Teresa Disingrini
  • SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS
    Publication number: 20140243347
    Abstract: The present invention relates to substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 28, 2014
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Francesco Casuscelli, Elena Casale, Marisa Montemartini, Claudia Piutti
  • Substituted pyrazolo-quinazoline derivatives as kinase inhibitors
    Patent number: 8541576
    Abstract: The present invention relates to substituted pyrazolo[4,3-h]quinazoline compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular PIM kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 24, 2013
    Assignee: Nerviano Medical Sciences SRL
    Inventors: Francesco Casuscelli, Claudia Piutti, Antonella Ermoli, Daniela Faiardi
  • Bicyclic pyrazoles as protein kinase inhibitors
    Patent number: 8524707
    Abstract: 3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: September 3, 2013
    Assignee: Nerviano Medical Sciences S.r.l.
    Inventors: Maurizio Pulici, Chiara Marchionni, Claudia Piutti, Fabio Gasparri
  • ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY
    Publication number: 20130143896
    Abstract: The present invention relates to substituted isoxazolo-quinazolines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular human MPS1 and PERK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: July 20, 2011
    Publication date: June 6, 2013
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Marina Caldarelli, Italo Beria, Nicoletta Colombo, Claudia Piutti, Matteo Salsa, Gabriella Traquandi
  • SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20120190678
    Abstract: The present invention relates to substituted pyrazolo[4,3-h]quinazoline compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular PIM kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: December 16, 2011
    Publication date: July 26, 2012
    Inventors: Francesco Casuscelli, Claudia Piutti, Antonella Ermoli, Daniela Faiardi
  • BICYCLIC PYRAZOLES AS PROTEIN KINASE INHIBITORS
    Publication number: 20110257165
    Abstract: 3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: December 17, 2009
    Publication date: October 20, 2011
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Maurizio Pulici, Chiara Marchionni, Claudia Piutti, Fabio Gasparri
  • Inhibitors of HCV NS5B polymerase
    Publication number: 20040142993
    Abstract: The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 22, 2004
    Inventors: Carlo Battistini, Francesco A. Casuscelli, Robert Charles Kelly, Linda L. Maggiora, Mark Allen Mitchell, Claudia Piutti, Matthew T. Reding
  • Chromane derivatives, process for their preparation and their use as antitumor agents
    Publication number: 20040116497
    Abstract: Compounds which are chromane derivatives of formula (I), pharmaceutically acceptable salts, process for their preparation and pharmaceutical compositions thereof are disclosed, as set forth in the specification; these compounds are useful in therapy in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
    Type: Application
    Filed: January 16, 2004
    Publication date: June 17, 2004
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Paolo Orsini, Claudia Piutti, Anna Vulpetti, Paolo Pevarello
  • Phenylacetamido-pyrazole derivatives and their use as antitumor agents
    Publication number: 20040019046
    Abstract: Phenylacetamido-pyrazoles and, more particularly, N-(5-cycloalkyl-1H-pyrazol-3-yl)phenylacetamido derivatives, optionally further substituted as reported in the description; or pharmaceutically acceptable salts thereof; are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
    Type: Application
    Filed: May 19, 2003
    Publication date: January 29, 2004
    Inventors: Paolo Pevarello, Paolo Orsini, Gabriella Traquandi, Gabriella Brasca, Raffaella Amici, Manuella Villa, Claudia Piutti, Mario Varasi, Antonio Longo
  • Phenylacetamido-pyrazole derivatives, process for their preparation and their use as antitumor agents
    Patent number: 6455559
    Abstract: Compounds represented by formula (I) wherein R is a C3-C5 cycloalkyl group, R1 is a hydrogen atom or a methyl group, or a pharmaceutically acceptable salt thereof; are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: September 24, 2002
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Paolo Pevarello, Paolo Orsini, Gabriella Traquandi, Maria Gabriella Brasca, Raffaella Amici, Manuela Villa, Claudia Piutti, Mario Varasi, Antonio Longo