Abstract: Provided herein are patient-controlled oral liquid-medicine dispenser and deactivation systems. The system includes a dosing container having a defined volumetric capacity and a spillway adapted and configured to allow fluid in excess of the defined volumetric capacity to flow out of the dosing container; a sealed and tamperproof waste receptacle fluidly coupled to the dosing container, the waste receptacle adapted and configured to capture and prevent diversion of liquid medicine dispensed in excess of the defined volumetric capacity of the dosing container; and a suction apparatus extending between a lower region of the dosing container and outside of the dosing container. Also provided herein are methods of administering a medication using the system.

Abstract: Provided herein are patient-controlled oral liquid-medicine dispenser and deactivation systems. The system includes a dosing container having a defined volumetric capacity and a spillway adapted and configured to allow fluid in excess of the defined volumetric capacity to flow out of the dosing container; a sealed and tamperproof waste receptacle fluidly coupled to the dosing container, the waste receptacle adapted and configured to capture and prevent diversion of liquid medicine dispensed in excess of the defined volumetric capacity of the dosing container; and a suction apparatus extending between a lower region of the dosing container and outside of the dosing container. Also provided herein are methods of administering a medication using the system.

Abstract: Aspects of the disclosure include apparatuses for and methods of removing a ligation clip interconnecting two mitral valve leaflets. Methods can include providing a mitral valve having first and second valve leaflets interconnected with a ligation clip. The ligation clip includes a base supporting a first and second retaining arms each having an end opposite the base. The first and second valve leaflets are compressed between the first and second retaining arms. The methods further include physically separating the ligation clip from both of the first and second leaflets with the apparatus, which is configured to dislodge the first and second leaflets from the ligation clip. The apparatuses are further configured to withdraw the ligation clip from the patient along with the apparatus.