Patents by Inventor Claudia Walls
Claudia Walls has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220340674Abstract: The invention relates to a method for the production of a bispecific CD30×CD16A antibody construct comprising a first binding domain for Fc?RIIIa comprising the steps chromatographically capturing the antibody construct from a solution; eluting the antibody construct from the capture matrix; reducing the pH in the solution of the eluted antibody construct to low pH, incubating the antibody construct under these conditions for at least 40 h and neutralizing thereafter.Type: ApplicationFiled: June 16, 2022Publication date: October 27, 2022Inventors: Claudia WALL, Michael WEICHEL
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Publication number: 20210024654Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: ApplicationFiled: March 18, 2020Publication date: January 28, 2021Inventors: Kristina Ellwanger, Luke Evnin, Judith A. Fox, Ivica Fucek, Jeanmarie Guenot, Stefan Knackmuss, Lori Kunkel, Melvyn Little, Vera Molkenthin, Erich Rajkovic, Uwe Reusch, Claudia Wall, Michael Weichel, Eugene Zhukovsky
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Patent number: 10626190Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: GrantFiled: October 27, 2017Date of Patent: April 21, 2020Assignee: Amphivena Therapeutics, Inc.Inventors: Kristina Ellwanger, Luke Evnin, Judith A. Fox, Ivica Fucek, Jeanmarie Guenot, Stefan Knackmuss, Lori Kunkel, Melvyn Little, Vera Molkenthin, Erich Rajkovic, Uwe Reusch, Claudia Wall, Michael Weichel, Eugene Zhukovsky
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Publication number: 20180291113Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: ApplicationFiled: October 27, 2017Publication date: October 11, 2018Inventors: Kristina ELLWANGER, Luke EVNIN, Judith A. FOX, Ivica FUCEK, Jeanmarie GUENOT, Stefan KNACKMUSS, Lori KUNKEL, Melvyn LITTLE, Vera MOLKENTHIN, Erich RAJKOVIC, Uwe REUSCH, Claudia WALL, Michael WEICHEL, Eugene ZHUKOVSKY
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Patent number: 9803029Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: GrantFiled: November 10, 2015Date of Patent: October 31, 2017Assignee: AMPHIVENA THERAPEUTICS, INC.Inventors: Kristina Ellwanger, Luke Evnin, Judith A. Fox, Ivica Fucek, Jeanmarie Guenot, Stefan Knackmuss, Lori Kunkel, Melvyn Little, Vera Molkenthin, Erich Rajkovic, Uwe Reusch, Claudia Wall, Michael Weichel, Eugene Zhukovsky
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Publication number: 20160194409Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: ApplicationFiled: November 10, 2015Publication date: July 7, 2016Inventors: Kristina ELLWANGER, Luke EVNIN, Judith A. FOX, Ivica FUCEK, Jeanmarie GUENOT, Stefan KNACKMUSS, Lori KUNKEL, Melvyn LITTLE, Vera MOLKENTHIN, Erich RAJKOVIC, Uwe REUSCH, Claudia WALL, Michael WEICHEL, Eugene ZHUKOVSKY
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Publication number: 20160002333Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: ApplicationFiled: March 9, 2015Publication date: January 7, 2016Inventors: Kristina ELLWANGER, Luke EVNIN, Judith A. FOX, Ivica FUCEK, Jeanmarie GUENOT, Stefan KNACKMUSS, Lori KUNKEL, Melvyn LITTLE, Vera MOLKENTHIN, Erich RAJKOVIC, Uwe REUSCH, Claudia WALL, Michael WEICHEL, Eugene ZHUKOVSKY
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Patent number: 9212225Abstract: Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).Type: GrantFiled: March 9, 2015Date of Patent: December 15, 2015Assignee: AMPHIVENA THERAPEUTICS, INC.Inventors: Kristina Ellwanger, Luke Evnin, Judith A. Fox, Ivica Fucek, Jeanmarie Guenot, Stefan Knackmuss, Lori Kunkel, Melvyn Little, Vera Molkenthin, Erich Rajkovic, Uwe Reusch, Claudia Wall, Michael Weichel, Eugene Zhukovsky
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Patent number: 7666818Abstract: A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.Type: GrantFiled: March 13, 2006Date of Patent: February 23, 2010Assignee: UT-Battelle, LLCInventors: Robert J. Lauf, Claudia A. Walls, Lynn A. Boatner
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Patent number: 7135288Abstract: A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.Type: GrantFiled: September 27, 2002Date of Patent: November 14, 2006Assignee: UT-Battelle, LLCInventors: Robert J. Lauf, Claudia A. Walls, Lynn A. Boatner
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Publication number: 20060151925Abstract: A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.Type: ApplicationFiled: March 13, 2006Publication date: July 13, 2006Inventors: Robert Lauf, Claudia Walls, Lynn Boatner
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Publication number: 20060154305Abstract: A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.Type: ApplicationFiled: March 13, 2006Publication date: July 13, 2006Inventors: Robert Lauf, Claudia Walls, Lynn Boatner
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Publication number: 20040062911Abstract: A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.Type: ApplicationFiled: September 27, 2002Publication date: April 1, 2004Inventors: Robert J. Lauf, Claudia A. Walls, Lynn A. Boatner
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Patent number: 6375877Abstract: A gelcasting method of making an internally graded article alternatively includes the steps of: preparing a slurry including a least two different phases suspended in a gelcasting solution, the phases characterized by having different settling characteristics; casting the slurry into a mold having a selected shape; allowing the slurry to stand for a sufficient period of time to permit desired gravitational fractionation in order to achieve a vertical compositional gradient in the molded slurry; gelling the slurry to form a solid gel while preserving the vertical compositional gradient in the molded slurry; drying the gel to form a dried green body; and sintering the dry green body to form a solid object, at least one property thereof varying along the vertical direction because of the compositional gradient in the molded slurry.Type: GrantFiled: April 24, 2001Date of Patent: April 23, 2002Assignee: UT Battelle, LLCInventors: Robert J. Lauf, Paul A. Menchhofer, Claudia A. Walls, Arthur J. Moorhead
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Patent number: 6365082Abstract: A polymer gel is formed into a mold defining a preselected shape. A flowable composition may be formed into a preselected shape via contact with the polymer gel mold.Type: GrantFiled: December 15, 1998Date of Patent: April 2, 2002Assignee: UT-Battelle, LLCInventors: Claudia A. Walls, Stephen D. Nunn, Mark A. Janney, April D. McMillan, Glen H. Kirby
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Publication number: 20010033039Abstract: A gelcasting method of making an internally graded article alternatively includes the steps of: preparing a slurry including a least two different phases suspended in a gelcasting solution, the phases characterized by having different settling characteristics; casting the slurry into a mold having a selected shape; allowing the slurry to stand for a sufficient period of time to permit desired gravitational fractionation in order to achieve a vertical compositional gradient in the molded slurry; gelling the slurry to form a solid gel while preserving the vertical compositional gradient in the molded slurry; drying the gel to form a dried green body; and sintering the dry green body to form a solid object, at least one property thereof varying along the vertical direction because of the compositional gradient in the molded slurry.Type: ApplicationFiled: April 24, 2001Publication date: October 25, 2001Inventors: Robert J. Lauf, Paul A. Menchhofer, Claudia A. Walls, Arthur J. Moorhead
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Publication number: 20010017342Abstract: A polymer gel is formed into a mold defining a preselected shape. A flowable composition may be formed into a preselected shape via contact with the polymer gel mold.Type: ApplicationFiled: March 8, 2001Publication date: August 30, 2001Inventors: Claudia A. Walls, Stephen D. Nunn, Mark A. Janney, April D. McMillan, Glen H. Kirby
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Patent number: 6248286Abstract: A gelcasting method of making an internally graded article includes the steps of: preparing at least two slurries, each of the slurries including a different gelcastable powder suspended in a gelcasting solution, the slurries characterized by having comparable shrinkage upon drying and sintering thereof; casting the slurries into a mold having a selected shape, wherein relative proportions of the slurries is varied in at least one direction within the selected shape; gelling the slurries to form a solid gel while preserving the variation in relative proportions of the slurries; drying the gel to form a dried green body; and sintering the dry green body to form a solid object, at least one property thereof varying because of the variation in relative proportions of the starting slurries.Type: GrantFiled: December 3, 1999Date of Patent: June 19, 2001Assignee: UT-Battelle, LLCInventors: Robert J. Lauf, Paul A. Menchhofer, Claudia A. Walls
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Patent number: 6066279Abstract: A method of gelcasting includes the steps of providing a solution of at least hydroxymethylacrylamide (HMAM) and water. At least one inorganic powder is added to the mixture. At least one initiator system is provided to polymerize the HMAM. The initiator polymerizes the HMAM and water, to form a firm hydrogel that contains the inorganic powder. One or more comonomers can be polymerized with the HMAM monomer, to alter the final properties of the gelcast material. Additionally, one or more additives can be included in the polymerization mixture, to alter the properties of the gelcast material.Type: GrantFiled: August 17, 1998Date of Patent: May 23, 2000Assignee: Lockheed Martin Energy Research Corp.Inventors: Claudia A. Walls, Glen H. Kirby, Mark A. Janney, Ogbemi O. Omatete, Stephen D. Nunn, April D. McMillan