Patents by Inventor Claudia Woppmann

Claudia Woppmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOUBLE-STRANDED RIBONUCLEIC ACID WITH INCREASED EFFECTIVENESS IN AN ORGANISM
    Publication number: 20100280102
    Abstract: The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.
    Type: Application
    Filed: June 16, 2010
    Publication date: November 4, 2010
    Applicant: Alnylam Pharmaceuticals
    Inventors: Claudia Woppmann, Hans-Peter Vornlocher, Philipp Hadwiger, Matthias John, Stefan Limmer
  • Double-stranded ribonucleic acid with increased effectiveness in an organism
    Patent number: 7786290
    Abstract: The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: August 31, 2010
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Claudia Woppmann, Hans-Peter Vornlocher, Philipp Hadwiger, Matthias John, Stefan Limmer
  • Double-Stranded Ribonucleic Acid with Increased Effectiveness in an Organism
    Publication number: 20070275465
    Abstract: The invention concerns a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, whereby the sequences of the single strands of the dsRNA are selected in such a way that on both ends of the dsRNA the last complementary nucleotide pair is a G-C, or at least two of the last four complementary nucleotide pairs are G-C pairs; whereby the dsRNA exhibits a single-stranded overhang consisting of 1 to 4 unpaired nucleotides at the first end, and no overhang at the second end; whereby the unpaired nucleotide of the single-stranded overhang that is directly adjacent to the last complementary nucleotide pair contains a purine base.
    Type: Application
    Filed: June 14, 2004
    Publication date: November 29, 2007
    Applicant: Alnylam Pharmaceuticals
    Inventors: Claudia Woppmann, Hans-Peter Vornlocher, Philipp Hadwiger, Matthias John, Stefan Limmer