Patents by Inventor Claudio Chuaqui

Claudio Chuaqui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210403495
    Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.
    Type: Application
    Filed: November 1, 2019
    Publication date: December 30, 2021
    Inventors: Jason J. Marineau, Michael Bradley, Claudio Chuaqui, Stephane Ciblat, Anzhelika Kabro
  • Publication number: 20210053984
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 27, 2020
    Publication date: February 25, 2021
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Publication number: 20200071326
    Abstract: Described herein are compounds, methods of making such compounds, compositions (e.g., pharmaceutical compositions/medicaments) that include such compounds, and methods of using such compounds to treat diseases, such as cancer.
    Type: Application
    Filed: April 13, 2018
    Publication date: March 5, 2020
    Inventors: Yi Zhang, Kathryn Austgen, Claudio Chuaqui, Goran Malojcic, William Sinko, Huiping Amy Guan, Tracey Lodie Savoie
  • Patent number: 10577380
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: March 3, 2020
    Assignee: Celgene CAR LLC
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Publication number: 20190375762
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 12, 2019
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Patent number: 10253040
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 9, 2019
    Assignee: Celgene CAR LLC
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Patent number: 9790235
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: October 17, 2017
    Assignee: Celgene CAR LLC
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Publication number: 20170114073
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 29, 2016
    Publication date: April 27, 2017
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Patent number: 9458175
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: October 4, 2016
    Assignee: Celgene Avilomics Research, Inc.
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh, Chittari Pabba
  • Publication number: 20160075720
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 16, 2015
    Publication date: March 17, 2016
    Inventors: Matthew David Alexander, Claudio Chuaqui, John Malona, Joseph John McDonald, Yike Ni, Deqiang Niu, Russell C. Petter, Juswinder Singh
  • Publication number: 20120040951
    Abstract: The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: December 30, 2009
    Publication date: February 16, 2012
    Inventors: Claudio Chuaqui, Jennifer Cossrow, James Dowling, Bing Guan, Michael Hoemann, Alexey Ishchenko, John Howard Jones, Lori Kabigting, Gnanasambandam Kumaravel, Hairuo Peng, Noel Powell, Brian Raimundo, Hiroko Tanaka, Kurt van Vloten, Jeffrey Vessels, Zhili Xin
  • Publication number: 20100166819
    Abstract: The invention is related to compounds of formula (I) that can be used as antagonists of the TGF? family type I receptors, Alk5 and/or Alk4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGF? family signaling activity is desirable.
    Type: Application
    Filed: December 22, 2006
    Publication date: July 1, 2010
    Inventors: Wen-Cherng Lee, Lihong Sun, Michael Hoemann, Deqiang Niu, Dingxue Yan, Claudio Chuaqui, Russell Petter, Helen (Xiaomei) Feng
  • Patent number: 7691865
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: April 6, 2010
    Assignee: Biogen Idec MA Inc.
    Inventors: Wen-Cherng Lee, Mary Beth Carter, Lihong Sun, Paul Lyne, Claudio Chuaqui, Zhongli Zheng, Juswinder Singh, Paula Boriack-Sjodin
  • Publication number: 20100056505
    Abstract: The invention is related to compounds of formula (I) as antagonists of the TGF? family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGF? family signaling activity is desirable.
    Type: Application
    Filed: November 21, 2006
    Publication date: March 4, 2010
    Inventors: Wen-Cherng Lee, Mary Beth Carter, Claudio Chuaqui, Kevin Guckian, Edward Lin, Michael J. Choi, Zhan Deng, Paula Ann Boriack-Sjodin, Lihong Sun
  • Patent number: 7612094
    Abstract: Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: November 3, 2009
    Assignee: Biogen Idec MA Inc.
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Zhongli Zheng, Russell C. Petter
  • Publication number: 20080171755
    Abstract: The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).
    Type: Application
    Filed: August 24, 2005
    Publication date: July 17, 2008
    Inventors: Wen-Cherng Lee, Lihong Sun, Claudio Chuaqui, Mark Comebise, Juswinder Singh, Feng Shan
  • Publication number: 20070134662
    Abstract: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning to each information unit a calculated value to represent the characteristic of a set of intermolecular interactions occurring at each selected position (i.e., a position on the target molecule at which intermolecular interaction occurs), a SIFt of the target molecule-ligand complex is constructed.
    Type: Application
    Filed: July 1, 2004
    Publication date: June 14, 2007
    Inventors: Juswinder Singh, Claudio Chuaqui, Zhan Deng
  • Publication number: 20070020642
    Abstract: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning to each information unit a calculated value to represent the characteristic of a set of intermolecular interactions occurring at each selected position (i.e., a position on the target molecule at which intermolecular interaction occurs), a SIFt of the target molecule-ligand complex is constructed.
    Type: Application
    Filed: August 18, 2005
    Publication date: January 25, 2007
    Inventors: Zhan Deng, Claudio Chuaqui, Juswinder Singh
  • Publication number: 20060264440
    Abstract: The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
    Type: Application
    Filed: February 12, 2004
    Publication date: November 23, 2006
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Mark Cornebise, Timothy Pontz, Mary Carter, Juswinder Singh, Paula Boriack-Sjodin, Leona Ling, Russell Petter
  • Publication number: 20060135517
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Application
    Filed: September 5, 2003
    Publication date: June 22, 2006
    Inventors: Wen-Cherng Lee, Mary Carter, Lihong Sun, Claudio Chuaqui, Juswinder Singh, Paula Boriack-Sjodin, Michael Choi