Patents by Inventor Claudio D. Denoya

Claudio D. Denoya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis
    Patent number: 6399324
    Abstract: The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel polypeptides produced by the expression of such sequences. It also relates to novel methods of enhancing the production of natural avermectin, of producing a Streptomyces avermitilis bkd mutant and of producing novel avermectins through fermentation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 4, 2002
    Assignee: Pfizer Inc.
    Inventors: Claudio D. Denoya, Kim J. Stutzman-Engwall
  • Process for dienone macrolides
    Patent number: 5776735
    Abstract: The process of this invention is directed to isolating or otherwise obtaining an olefinic macrolide producing microorganism which microorganism does not contain epoxidase enzyme activity. This invention also relates to a process for preparing said olefinic macrolide by fermenting a mutant microorganism lacking epoxidase activity, designated rosX herein, which mutant is obtained from the wild-type microorganism. This invention also relates to a rosX mutant of Micromonospora rosaria, and to any microorganism having the identifying characteristics thereof, said mutant also designated ATCC 55709. This invention also relates to a process for preparing repromicin, the compound of formula (II), ##STR1## by mutating a wild-type microorganism capable of producing rosamicin to produce a mutant microorganism lacking epoxidase activity such that repromicin is produced by said mutant microorganism.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: July 7, 1998
    Assignee: Pfizer Inc.
    Inventors: Claudio D. Denoya, Edmund W. Hafner, Hamish A. I. McArthur
  • Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis
    Patent number: 5728561
    Abstract: The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel polypeptides produced by the expression of such sequences. It also relates to novel methods of enhancing the production of natural avermectin and of producing novel avermectin through fermentation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 17, 1998
    Assignee: Pfizer Inc.
    Inventor: Claudio D. Denoya
  • Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
    Patent number: 5707839
    Abstract: The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel polypeptides produced by the expression of such sequences. It also relates to novel methods of enhancing the production of natural avermectin, of producing a Streptomyces avermitilis bkd mutant and of producing novel avermectins through fermentation.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 13, 1998
    Assignee: Pfizer Inc.
    Inventors: Claudio D. Denoya, Kim J. Stutzman-Engwall