Patents by Inventor Claudio DELFRATE

Claudio DELFRATE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PRODUCTION OF 21-(ACETYLOXY)-17-(PROPIONYLOXY)-PREGN-4-ENE-3,20-DIONE
    Publication number: 20240018181
    Abstract: The present invention relates to a process for the preparation of 21-(acetyloxy)-17-(1-oxopropoxy)-pregn-4-ene-3,20-dione (VI) having the formula below: Compound (VI) can be used as a precursor for the synthesis of Clascoterone, a steroid used for the treatment of acne.
    Type: Application
    Filed: February 5, 2021
    Publication date: January 18, 2024
    Inventors: Roberto Lenna, Claudio Delfrate, Davide Rigamonti, Silvia Genovese
  • PROCESS FOR PREPARING (3alpha,5alpha)-3-HYDROXY-3-METHYL-PREGNAN-20-ONE (GANAXOLONE)
    Publication number: 20230322844
    Abstract: The present invention refers to a process for preparing (3?,5?)-hydroxy-3-methyl-pregnan-20-one, a compound also known as Ganaxolone, having the formula below: (I):
    Type: Application
    Filed: September 8, 2021
    Publication date: October 12, 2023
    Inventors: Roberto Lenna, Andrea Fasana, Claudio Delfrate, Jerry David Ortiz Blacio
  • PROCESS FOR THE PREPARATION OF 3ALPHA-HYDROXY-5ALPHA-PREGNAN-20-0NE (BREXANOLONE)
    Publication number: 20210388020
    Abstract: The present invention relates to a new process for the synthesis of 3?-hydroxy-5?-pregnan-20-one, commonly known as brexanolone, wherein the corresponding cyclic 20-ketal or cyclic 20-thioketal compound of formula (IV) is deprotected with the use or iodine in an organic solvent: (I).
    Type: Application
    Filed: October 21, 2019
    Publication date: December 16, 2021
    Inventors: Claudio DELFRATE, Davide RIGAMONTI, Tea BORELLI, Roberto LENNA
  • Process for the preparation of 9 beta,10 alpha-progesterone (retroprogesterone)
    Patent number: 10654885
    Abstract: The present invention refers to a new process for the synthesis of (9?,10?)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: May 19, 2020
    Assignee: INDUSTRIALE CHIMCA S.R.L.
    Inventors: Roberto Lenna, Claudio Delfrate, Davide Rigamonti
  • PROCESS FOR THE PREPARATION OF 9 BETA,10 ALPHA-PROGESTERONE (RETROPROGESTERONE)
    Publication number: 20200040029
    Abstract: The present invention refers to a new process for the synthesis of (9?,10?)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.
    Type: Application
    Filed: January 18, 2018
    Publication date: February 6, 2020
    Inventors: Roberto LENNA, Claudio DELFRATE, Davide RIGAMONTI