Abstract: Bio-electro reactors with real-time adjustable electric parameters and sequencing programmable power supplies are disclosed. According to an aspect, a bio-electro reactor for control of electrolysis gases bubbles within a biologically-active substance includes a vessel defining an interior for holding a biologically-active substance. The bio-electro reactor also includes electrodes positioned to be electrically coupled with at least a portion of the biologically-active substance. Further, the bio-electro reactor includes an electric source configured to apply voltage across the electrodes. The bio-electro reactor also includes an electrical controller configured to determine an electrical impedance at one or more of the electrodes for use in controlling electrolysis gases bubbles within the biologically active substance.