Patents by Inventor Claudio Maldonado

Claudio Maldonado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATING MICROVASCULAR DYSFUNCTION
    Publication number: 20230165796
    Abstract: The present disclosure relates to compositions comprising phospholipids, lipid vesicles, and/or liposomes, and methods of use thereof. In one aspect, the present disclosure relates to methods and compositions for delivery of, biologically active lipids to reduce microvascular dysfunction and infarct size during revascularization of the blocked artery in a mammalian subject.
    Type: Application
    Filed: January 24, 2023
    Publication date: June 1, 2023
    Inventors: Claudio Maldonado, Phillip Bauer
  • Treating microvascular dysfunction
    Patent number: 11590079
    Abstract: The present disclosure relates to compositions comprising phospho-lipids, lipid vesicles, and/or liposomes, and methods of use thereof. In one aspect, the present disclosure relates to methods and compositions for delivery of, biologically active lipids to reduce microvascular dysfunction and infarct size during revascularization of the blocked artery in a mammalian subject.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: February 28, 2023
    Assignee: EndoProtech, Inc.
    Inventors: Claudio Maldonado, Phillip Bauer
  • TREATING MICROVASCULAR DYSFUNCTION
    Publication number: 20200338003
    Abstract: The present disclosure relates to compositions comprising phospho-lipids, lipid vesicles, and/or liposomes, and methods of use thereof. In one aspect, the present disclosure relates to methods and compositions for delivery of, biologically active lipids to reduce microvascular dysfunction and infarct size during revascularization of the blocked artery in a mammalian subject.
    Type: Application
    Filed: January 18, 2019
    Publication date: October 29, 2020
    Inventors: Claudio Maldonado, Phillip Bauer
  • ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE
    Publication number: 20190275003
    Abstract: Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
    Type: Application
    Filed: November 8, 2017
    Publication date: September 12, 2019
    Inventors: Claudio Maldonado, Craig McClain, Shirish S. Barve, Leila Gobejishvili, Philip Bauer
  • CELL-SURFACE DECORATION WITH ACTIVE AGENTS
    Publication number: 20160120807
    Abstract: A lipid vesicle comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent and the active agent are provided. Methods of decorating endothelial cells, tissues, and organs with active agents utilizing the disclosed lipid vesicles are also provided.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 5, 2016
    Inventors: Claudio Maldonado, Federico V. Grossi, Gustavo Perez-Abadia, William D. Ehringer
  • CELL-SURFACE DECORATION WITH ACTIVE AGENTS
    Publication number: 20090202621
    Abstract: A lipid vesicle comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent and the active agent are provided. Methods of decorating endothelial cells, tissues, and organs with active agents utilizing the disclosed lipid vesicles are also provided.
    Type: Application
    Filed: May 1, 2006
    Publication date: August 13, 2009
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Claudio Maldonado, Federico V. Grossi, Gustavo Perez-Abadia, William D. Ehringer