Abstract: Disclosed are compounds including phosphate and N-oxide prodrugs of the NK1 antagonist netupitant, useful in the prevention and/or treatment of diseases including emesis induced by chemotherapy. Also disclosed are methods of making a di-tert-butyl (chloromethyl) phosphate useful in the manufacture of such prodrugs by reacting a dialkylphosphate salt with an acid to obtain the corresponding ester of phosphoric acid, reacting the ester with a quaternary ammonium hydroxide base to form a monobasic salt, and reacting the monobasic salt with chloroiodomethane to form the corresponding chloromethyl dialkyl phosphate.

Abstract: Disclosed is a cracker including: a first section, adapted to be garnished or to come into contact with accompanying foods; and a second section, adapted to act as holding means for the fingers of the consumer, remaining extraneous, in use, to contact with the accompanying foods. The first and the second section coact with each other to define geometric shapes adapted to evoke objects associable through use or affinity with the accompanying foods or in any case to bring to mind and visually suggest the nature of the accompanying foods arranged on the first section or that must be picked up therewith.