Patents by Inventor Claudio Soto

Claudio Soto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070020682
    Abstract: The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in the pathogenesis of transmissible spongiform encephalopathics and other prion diseases.
    Type: Application
    Filed: June 18, 2004
    Publication date: January 25, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Claudio Soto-Jara, Kinsey Maundrell
  • Publication number: 20070009964
    Abstract: The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with natural OX40L for blocking OX40R-mediated cell signaling in the prophylaxis and/or treatment of diseases related to activated T cells.
    Type: Application
    Filed: April 2, 2003
    Publication date: January 11, 2007
    Applicant: Applied Research Systmes ARD Holding N.V.
    Inventors: Claudio Soto-Jara, Claudia Pena-Rossi
  • Publication number: 20060281686
    Abstract: Provided are peptides comprising at least one azaamino acid and having ?-sheet breaking ability, useful in the treatment and prevention of diseases such as alzheimer's disease, Dementia Pugilistica (including head trauma), Hereditary Cerebral Haemorrhage with amyloidosis of the Dutch type (HCHWA-D) and Vascular Dementia with amyloid angiopathy.
    Type: Application
    Filed: December 1, 2003
    Publication date: December 14, 2006
    Inventors: John Lopez Areiza, Thomas Rueckle, Claudio Soto-Jara
  • Publication number: 20060263767
    Abstract: A highly sensitive method is provided for the detection of prions in a sample. These methods may be used to diagnose prion mediated transmissible spongiform encephalopathies such as bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, scrapie, or chronic wasting disease. In particular a method for serial automated cyclic amplification of prion is disclosed. The method is both rapid and highly sensitive making it ideal for high throughput testing.
    Type: Application
    Filed: April 20, 2006
    Publication date: November 23, 2006
    Inventors: Joaquin Castrillon, Paula Prieto, Claudio Soto-Jara
  • Publication number: 20060069058
    Abstract: The present invention provides peptide analogs and peptide mimetics that inhibit pleated sheet formation in amyloid ?-peptide, pharmaceutical compositions thereof and their therapeutic use. The inhibitory peptides possess activity as inhibitors in the formation of amyloid-like deposits and are useful in the treatment of Alzheimer's Disease.
    Type: Application
    Filed: November 9, 2005
    Publication date: March 30, 2006
    Applicant: Axonyx, Inc.
    Inventor: Claudio Soto-Jara
  • Publication number: 20050181998
    Abstract: Short peptides and derivatives or analogs thereof for the treatment or prevention of transmissible spongiform encephalopathies, in particular CJD are herein described.
    Type: Application
    Filed: December 9, 2002
    Publication date: August 18, 2005
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Celine Adessi, Serge Halazy, Gabriela Saborio, Claudio Soto-Jara
  • Publication number: 20050159349
    Abstract: The present invention relates generally to bacterial proteins, particularly to apoptogenic-bacteriocins, which are capable of killing other bacteria and of also inducing apoptosis in certain eukaryotic cells. The apoptogenic-bacteriocin of the present invention produces apoptosis in tumor-derived cells or cancer cells, while being not cytotoxic to normal cells and not inducing any evident toxicityin vivo in normal animals. Uses of the apoptogenic-bacteriocin and methods of treating cancer, tumors and other diseases of the aberrant cell growth are provided.
    Type: Application
    Filed: March 5, 2003
    Publication date: July 21, 2005
    Inventors: Claudio Soto, Rosalba Lagos
  • Publication number: 20050064505
    Abstract: A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.
    Type: Application
    Filed: June 13, 2001
    Publication date: March 24, 2005
    Inventors: Claudio Soto-Jara, Gabriella Saborio
  • Publication number: 20040121960
    Abstract: The present invention is an inhibitory peptide capable of inhibiting &bgr; pleated sheet formation in amyloid &bgr;-peptide. The inhibitory peptide is a &bgr;sheet breaker peptide analog designed by chemical modification of a &bgr;sheet breaker peptide capable of inhibiting &bgr; pleated sheet formation in amyloid &bgr;-peptide.
    Type: Application
    Filed: December 3, 2003
    Publication date: June 24, 2004
    Inventor: Claudio Soto-Jara
  • Patent number: 6689753
    Abstract: The present invention provides peptide analogs and peptide mimetics that inhibit pleated sheet formation in amyloid &bgr;-peptide, pharmaceutical compositions thereof and their therapeutic use. The inhibitory peptides possess activity as inhibitors in the formation of amyloid-like deposits and are useful in the treatment of Alzheimer's Disease.
    Type: Grant
    Filed: November 4, 2000
    Date of Patent: February 10, 2004
    Assignee: Axonyx, Inc.
    Inventor: Claudio Soto-Jara
  • Publication number: 20030087407
    Abstract: Novel peptides capable of interacting with a hydrophobic &bgr;-sheet forming cluster of amino acid residues on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits and into pathological &bgr;-sheet-rich conformation as precursors thereof. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.
    Type: Application
    Filed: September 6, 2002
    Publication date: May 8, 2003
    Applicant: New York University
    Inventors: Claudio Soto-Jara, Marc H. Baumann, Blas Frangione
  • Patent number: 6462171
    Abstract: Novel peptides capable of interacting with a hydrophobic &bgr;-sheet forming cluster of amino acid residues on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits and into pathological &bgr;-sheet-rich conformation as precursors thereof. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.
    Type: Grant
    Filed: December 12, 1996
    Date of Patent: October 8, 2002
    Assignee: New York University
    Inventors: Claudio Soto-Jara, Marc H. Baumann, Blas Frangione
  • Patent number: 5948763
    Abstract: Novel peptides capable of interacting with a hydrophobic structural determinant on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: September 7, 1999
    Assignee: New York University
    Inventors: Claudio Soto-Jara, Marc H. Baumann, Blas Frangione