Patents by Inventor Claudio Vinegoni

Claudio Vinegoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM AND METHOD FOR DETERMINATION OF LIGAND-TARGET BINDING BY MULTI-PHOTON FLUORESCENCE ANISOTROPY MICROSCOPY
    Publication number: 20190072562
    Abstract: A multiphoton fluorescence anisotropy microscopy live cell imaging system and method to measure and map drug-target interaction in real time at subcellular resolution. Proposed modality enables a direct measurement of drug/target binding in vivo, high-resolution spatial and temporal mapping of bound and unbound drug distribution, and presents an versatile tool to enhance understanding of drug activity. Application of the system to measurement of intracellular target engagement of the chemotherapeutic Olaparib, a poly(ADP-ribose) polymerase inhibitor, in live cells and within a tumor in vivo.
    Type: Application
    Filed: November 2, 2018
    Publication date: March 7, 2019
    Inventors: Claudio Vinegoni, Ralph Weissieder, J. Matthew Dubach, Ralph Mazitschek
  • SYSTEM AND METHOD FOR DETERMINATION OF LIGAND-TARGET BINDING BY MULTI-PHOTON FLUORESCENCE ANISOTROPY MICROSCOPY
    Publication number: 20170045521
    Abstract: A multiphoton fluorescence anisotropy microscopy live cell imaging system and method to measure and map drug-target interaction in real lime at subcellular resolution. Proposed modality enables a direct measurement of drug/target binding in vivo, high-resolution spatial and temporal snapping of bound and unbound drug distribution, and presents an versatile tool to enhance understanding of drug activity. Application of tire system to measurement of intracellular target engagement of the chemotherapeutic Olaparib, a poly(ADP-ribose) polymerase inhibitor, in live cells and within a tumor in vivo.
    Type: Application
    Filed: April 22, 2015
    Publication date: February 16, 2017
    Inventors: Claudio Vinegoni, Ralph Weissieder, Matt Dubach, Ralph Mazitschek