Patents by Inventor Claus Andre Frank Rental

Claus Andre Frank Rental has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DETECTION, IDENTIFICATION AND QUANTIFICATION OF IMPURITIES
    Publication number: 20090095896
    Abstract: Provided is a method comprising introducing a sample comprising a plurality of oligonucleotides into an ion pair high performance liquid chromatography column having a buffered mobile phase and allowing at least a portion of the oligonucleotides to separate; allowing the oligonucleotides to elute from the column; and introducing the oligonucleotides into a mass spectrometer and quantifying at least a portion of the oligonucleotides by mass spectrometry. In the method, at least a portion of the oligonucleotides are co-eluting oligonucleotides that differ in mass by no more than 20%; and the buffered mobile phase causes at least 50 mole percent of co-eluting oligonucleotides to have the same charge when they enter the mass spectrometer.
    Type: Application
    Filed: March 31, 2006
    Publication date: April 16, 2009
    Applicant: IsIs Pharmaceuticales , Inc.
    Inventors: Christine Kurata, Daniel Capaldi, Zhiwei Wang, Nhuy Luu, Hans-Joachim Gaus, Claus Andre Frank Rental