Patents by Inventor Claus Becker
Claus Becker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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METHOD FOR INDICATING THE PROGRESS OF AMPLIFICATION OF NUCLEIC ACIDS AND KIT FOR PERFORMING THE SAME
Publication number: 20220098641Abstract: It is disclosed a method for the detection of an amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification is detected by a detection system.Type: ApplicationFiled: June 22, 2021Publication date: March 31, 2022Inventors: Christian Grunwald, Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann -
Publication number: 20220073967Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complemetary base pair formation between the activator oligonucleotide and the corresponding target sequence.Type: ApplicationFiled: October 28, 2021Publication date: March 10, 2022Inventors: Dmitry CHERKASOV, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
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Patent number: 11203780Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complementary base pair formation between the activator oligonucleotide and the corresponding target sequence.Type: GrantFiled: February 20, 2020Date of Patent: December 21, 2021Inventors: Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
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Method for indicating the progress of amplification of nucleic acids and kit for performing the same
Patent number: 11072825Abstract: It is disclosed a method for the detection of an amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification is detected by a detection system.Type: GrantFiled: February 25, 2019Date of Patent: July 27, 2021Inventors: Christian Grunwald, Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann -
Publication number: 20210189479Abstract: A method is disclosed for detecting an amplification of nucleic acids in which use is essentially made of the fact that a predefined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target-sequence-specific activator oligonucleotide. The target-sequence-specific activator oligonucleotide brings about the separation of de-novo synthesized complementary primer elongation products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective strand of the template. The complex thus formed, of a primer oligonucleotide and a template strand, can initiate a new primer elongation reaction. The primer elongation products thus formed, in turn, act again as templates, the result being an exponentially proceeding amplification reaction. In the method, a selective amplification is effected in that, for the first, second primer and activator oligonucleotide, variants are used which differ from the target sequence by at least one nucleotide.Type: ApplicationFiled: February 25, 2019Publication date: June 24, 2021Inventors: Christian Grunwald, Dmitry Cherkasov, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MUELLER-HERMANN
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METHOD FOR INDICATING THE PROGRESS OF AMPLIFICATION OF NUCLEIC ACIDS AND KIT FOR PERFORMING THE SAME
Publication number: 20210024978Abstract: It is disclosed a method for the detection of an amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification is detected by a detection system.Type: ApplicationFiled: February 25, 2019Publication date: January 28, 2021Applicant: AGCT GmbHInventors: Christian GRUNWALD, Dmitry CHERKASOV, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MÜLLER-HERMANN -
Publication number: 20200239933Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complemetary base pair formation between the activator oligonucleotide and the corresponding target sequence.Type: ApplicationFiled: February 20, 2020Publication date: July 30, 2020Inventors: Dmitry CHERKASOV, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MUELLER-HERMANN
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Patent number: 10612082Abstract: A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results.Type: GrantFiled: August 21, 2017Date of Patent: April 7, 2020Assignee: AGCT GmbHInventors: Dmitry Cherkasov, Norbert Basler, Claus Becker, Hans-Joerg Hess, Andreas Mueller-Hermann
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Publication number: 20190185914Abstract: It is disclosed a method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by means of strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Here, the activator oligonucleotide itself does not function as a template and preferably is inert over a primer extension reaction.Type: ApplicationFiled: August 21, 2017Publication date: June 20, 2019Inventors: Dmitry CHERKASOV, Norbert BASLER, Claus BECKER, Hans-Joerg HESS, Andreas MUELLER-HERMANN
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Patent number: 9994894Abstract: The invention relates to a novel method for the enzymatic marking of nucleic acid chains (target sequences) by means of nucleotide conjugates. Said nucleotide conjugates are able, under reaction conditions, to specifically bind to the target sequence and integrate into the complementary growing strand by means of a polymerase. The nucleic acid chains marked by such conjugates can be bound to the solid phase. The marking can be carried out parallel to the enzymatic amplification of target sequences.Type: GrantFiled: April 26, 2012Date of Patent: June 12, 2018Assignee: AGCT GMBHInventors: Dmitry Cherkasov, Claus Becker, Norbert Basler, Andreas Muller-Hermann, Petra Van Husen
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Publication number: 20160340724Abstract: Methods for enzymatic synthesis of nucleic acid chains are disclosed in which a nucleotide-macromolecular conjugate is incorporated into the complementary strand of a target sequence.Type: ApplicationFiled: March 11, 2016Publication date: November 24, 2016Inventors: Claus BECKER, Dmitry CHERKASOV
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Patent number: 9315860Abstract: The invention relates to a novel method for enzymatically marking nucleic acid chains (target sequences) by using nucleotide conjugates. Said nucleotide conjugates are capable of binding specifically to the target sequence under reaction conditions and of being incorporated in the complementary growing strand by means of a polymerase. The nucleic acid chains marked with such conjugates can be bound to the solid phase. The marking can be carried out in parallel with the enzymatic amplification of target sequences.Type: GrantFiled: October 26, 2010Date of Patent: April 19, 2016Assignee: GENOVOXX GMBHInventors: Claus Becker, Dmitry Cherkasov
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Publication number: 20150086981Abstract: The invention relates to a novel method for the enzymatic marking of nucleic acid chains (target sequences) with nucleotide conjugates. Under reaction conditions, said nucleotide conjugates are able to bind to a target sequence, and can be incorporated into the complementary growing strand by way of a polymerase. The nucleotide conjugates can be used for sequencing nucleic acid chains.Type: ApplicationFiled: May 4, 2012Publication date: March 26, 2015Applicant: GENOVOXX GMBHInventors: Dmitry Cherkasov, Claus Becker, Norbert Basler, Andreas Müller-Hermann, Petra Van Husen
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Publication number: 20140295438Abstract: The invention relates to a novel method for the enzymatic marking of nucleic acid chains (target sequences) by means of nucleotide conjugates. Said nucleotide conjugates are able, under reaction conditions, to specifically bind to the target sequence and integrate into the complementary growing strand by means of a polymerase. The nucleic acid chains marked by such conjugates can be bound to the solid phase. The marking can be carried out parallel to the enzymatic amplification of target sequences.Type: ApplicationFiled: April 26, 2012Publication date: October 2, 2014Applicant: GENOVOXX GMBHInventors: Dmitry Cherkasov, Claus Becker, Norbert Basler, Andreas Muller-Hermann, Petra Van Husen
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Publication number: 20140132285Abstract: A method of verifying a correct adhesion of a substrate on a body which is configured to be electrically conductive and thermally conductive includes providing the body, providing the substrate comprising a top face and a rear face, connecting to the top face of the substrate an electric circuit comprising conductive paths and electronic components, attaching to the rear face the body via an adhesive layer comprising an adhesive, connecting the conductive paths and the body to an respective opposite terminal of a voltage source via contact tabs, measuring a capacity, and determining a quality of the adhesive layer from the measured capacity.Type: ApplicationFiled: June 6, 2012Publication date: May 15, 2014Applicant: PIERBURG PUMP TECHNOLOGY GMBHInventors: Hagen Friede, Hartmut Selter, Claus Becker
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Publication number: 20130171631Abstract: The invention relates to a novel method for enzymatically marking nucleic acid chains (target sequences) by using nucleotide conjugates. Said nucleotide conjugates are capable of binding specifically to the target sequence under reaction conditions and of being incorporated in the complementary growing strand by means of a polymerase. The nucleic acid chains marked with such conjugates can be bound to the solid phase. The marking can be carried out in parallel with the enzymatic amplification of target sequences.Type: ApplicationFiled: October 26, 2010Publication date: July 4, 2013Inventors: Claus Becker, Dmitry Cherkasov
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Patent number: 4600988Abstract: A multiprocessor system having a memory-programmable control of the type having a processor unit, coupling memories and input and output modules for transferring signals to and from a process which is to be controlled. Each processor unit is provided with a subprogram and a data memory which can be accessed directly, and a bus control unit releases access to the common system bus always for only one of the processor units. The access sequence and the access duration of the individual processor units to the common bus, via which the signals run to and from the controlled process, are fixed in a bus assignment matrix. In this manner, simple synchronization of the processor units is achieved. Moreover, guaranteed reaction times with respect to the process are possible.Type: GrantFiled: September 13, 1983Date of Patent: July 15, 1986Assignee: Siemens AktiengesellschaftInventors: Gautan Tendulkar, Claus Becker, Wolfgang Richter
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Patent number: 4165167Abstract: A viewfinder and exposure factor indicator system for photographic cameras comprising an indicator panel, a micro-luminous element for illuminating said panel, and a reproduction system arranged between the luminous element and the indicator panel. The image of said luminous element can be reproduced at the exit of said viewfinder system.Type: GrantFiled: June 24, 1977Date of Patent: August 21, 1979Assignee: Veb Pentacon Dresden Kamera-UndkinowerkeInventors: Rolf Jurenz, Claus Becker