Patents by Inventor Claus Christiansen
Claus Christiansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140271735Abstract: The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicant: Novartis AGInventors: Moise Azria, Claus Christiansen, Simon David Bateman, Shoufeng Li
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Patent number: 8835389Abstract: The present invention relates to a novel use of calcitonin in rheumatoid arthritis, and to methods of treating and/or preventing rheumatoid arthritis and conditions associated therewith in mammals, particularly humans. In particular, a method is provided of preventing or/and treating rheumatoid arthritis in a patient in need thereof comprising administering to said patient a therapeutically effective amount of calcitonin, e.g. salmon calcitonin in free form or salt form, in a pharmaceutically acceptable oral delivery form, wherein the therapeutically effective amount of a calcitonin is delivered orally in a composition comprising the calcitonin and a delivery agent for calcitonin.Type: GrantFiled: November 3, 2006Date of Patent: September 16, 2014Assignees: Novartis AG, Nordic Bioscience A/SInventors: Moise Azria, Claus Christiansen
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Patent number: 8765675Abstract: The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.Type: GrantFiled: June 21, 2010Date of Patent: July 1, 2014Assignee: Novartis AGInventors: Moise Azria, Claus Christiansen, Simon David Bateman, Shoufeng Li
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Patent number: 8300910Abstract: A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure representative of cartilage homogeneity is derived from this three dimensional image data. The measured value is compared with similar measured values previously established in respect of healthy joints and/or joints characterised by a pathology.Type: GrantFiled: September 19, 2007Date of Patent: October 30, 2012Assignee: Synarc Inc.Inventors: Erik B. Dam, Arish Qazi, Morten Karsdal, Paola C. Petterson, Mads Nielsen, Claus Christiansen
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Patent number: 8280126Abstract: A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure of local curvature of the cartilage is determined within a region of interest. The value of the quantitative parameter of this joint derived from this measure is compared with the value of a similar quantitative parameter previously established in respect of healthy joints and/or joints characterized by a pathology.Type: GrantFiled: September 4, 2006Date of Patent: October 2, 2012Assignee: Synarc Inc.Inventors: Erik B. Dam, Jenny Folkesson, Paola Pettersen, Ole F. Olsen, Mads Nielsen, Claus Christiansen
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Publication number: 20120219603Abstract: The present invention relates to a novel use of calcitonin in rheumatoid arthritis, and to methods of treating and/or preventing rheumatoid arthritis and conditions associated therewith in mammals, particularly humans. In particular, a method is provided of preventing or/and treating rheumatoid arthritis in a patient in need thereof comprising administering to said patient a therapeutically effective amount of calcitonin, e.g. salmon calcitonin in free form or salt form, in a pharmaceutically acceptable oral delivery form, wherein the therapeutically effective amount of a calcitonin is delivered orally in a composition comprising the calcitonin and a delivery agent for calcitonin.Type: ApplicationFiled: March 1, 2012Publication date: August 30, 2012Inventors: Moise AZRIA, Claus Christiansen
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Publication number: 20120046224Abstract: Enterally administered calcitonin family members other than amylin, particularly calcitonin itself, are effective to treat Type I diabetes, Type II diabetes or metabolic syndrome, for mitigating insulin resistance, and for reducing serum glucose levels.Type: ApplicationFiled: March 10, 2010Publication date: February 23, 2012Applicant: NORDIC BIOSCIENCE A/SInventors: Morten A. Karsdal, Claus Christiansen
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Publication number: 20110142307Abstract: The risk of future fracture or deformity of vertebrae of a spine may be estimated by processing an image of at least one vertebra of a spine to compare data representing the appearance of the at least one vertebra with a statistical model of a corresponding part of a spine, the statistical model being formed from data representing images of spines for which information about the degree of fracture or deformity of each spine at a subsequent time is known, and deriving a measure of the similarity between the at least one vertebra of the spine and the model, which measure is representative of the likelihood that the spine will subsequently sustain a fracture or become deformed.Type: ApplicationFiled: April 9, 2009Publication date: June 16, 2011Applicant: NORDIC BIOSCIENCE IMAGING A/SInventors: Anarta Ghosh, Mads Nielsen, Morten A. Karsdal, Claus Christiansen, Paola Pettersen, Marleen De Bruijne
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Patent number: 7844090Abstract: A method of deriving a quantitative measure of a degree of calcification of a blood vessel such as an aorta by processing an image such as an X-ray image of at least a part of the blood vessel containing said calcification comprises: taking a starting set of digital data representative of an image of at least part of a blood vessel containing a calcification set against a background; estimating the boundary of the calcification; using inpainting to replace digital data in said starting set representing the calcification with data extrapolating the boundary of the background to extend over the area of calcification, and so generating an inpainted set of digital data; and computing the difference between the starting set of digital data and the inpainted set of digital data to obtain a quantitative measure of the degree of calcification of the blood vessel.Type: GrantFiled: June 2, 2006Date of Patent: November 30, 2010Assignee: Nordic Bioscience Imaging A/SInventors: Marleen De Bruijne, Mads Nielsen, Claus Christiansen, Lars A. Conrad-Hansen, Francois B. Lauze
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Publication number: 20100278881Abstract: The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.Type: ApplicationFiled: June 21, 2010Publication date: November 4, 2010Applicant: Novartis AGInventors: Moise AZRIA, Claus Christiansen, Simon David Bateman, Shoufeng Li
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Publication number: 20100220907Abstract: A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure representative of cartilage homogeneity is derived from this three dimensional image data. The measured value is compared with similar measured values previously established in respect of healthy joints and/or joints characterised by a pathology.Type: ApplicationFiled: September 19, 2007Publication date: September 2, 2010Applicant: Nordic Bioscience Imaging A/SInventors: Erik B. Dam, Arish Qazi, Morten Karsdal, Paola C. Petterson, Mads Nielsen, Claus Christiansen
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Patent number: 7749954Abstract: The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.Type: GrantFiled: July 22, 2004Date of Patent: July 6, 2010Assignee: Novartis AGInventors: Moise Azria, Claus Christiansen, Simon David Bateman, Shoufeng Li
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Publication number: 20100135549Abstract: A method of processing data derived from an image of at least part of a spine is provided for estimating the risk of a future fracture in vertebrae of the spine. Position data relating to at least four neighbouring vertebrae of the spine is processed. The curvature of the spine at least two of the neighbouring vertebrae is calculated. The different curvature values are computed to obtain a value representative of the degree of irregularity in curvature of the spine and using the degree of irregularity, an estimate of the risk of a future fracture in vertebrae of the spine is provided. A higher degree of irregularity indicates a higher risk of future fracture.Type: ApplicationFiled: March 27, 2008Publication date: June 3, 2010Applicant: Nordic Bioscience Imaging A/SInventors: Paola Pettersen, Marleen De Bruijne, Claus Christiansen, László B. Tankó
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Publication number: 20090299769Abstract: A computer based calculation of a prognostic index I of osteoarthritis based on biochemical and imaging based biomarkers a mathematical combination of said values, wherein a first imaging based biomarker is a measure of the quantity of a cartilage in a joint compartment, a second imaging based biomarker relating to the quality of said cartilage in said joint compartment, and wherein a value of said first biomarker indicative of a larger quantity of cartilage affects the index to make it predictive of more disease progression, and a value of said second biochemical marker indicative of a greater departure from the quality of disease free cartilage affects the index to make it predictive of more risk of disease progression, exemplified by I = yHom + zVol + ? n = 1 N ? a n ? Other n where y and z are numerical coefficients, Hom is the measured homogeneity, Vol is the measured cartilage volume, and where Othern represents N further biomarkers each having a respective numerical coefficient anType: ApplicationFiled: May 29, 2009Publication date: December 3, 2009Applicant: Nordic Bioscience Imaging A/SInventors: Erik B. Dam, Marco Loog, Morten Karsdal, Mads Nielsen, Claus Christiansen
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Publication number: 20090216094Abstract: A method of deriving a quantitative measure of a degree of calcification of a blood vessel such as an aorta by processing an image such as an X-ray image of at least a part of the blood vessel containing said calcification comprises: taking a starting set of digital data representative of an image of at least part of a blood vessel containing a calcification set against a background; estimating the boundary of the calcification; using inpainting to replace digital data in said starting set representing the calcification with data extrapolating the boundary of the background to extend over the area of calcification, and so generating an inpainted set of digital data; and computing the difference between the starting set of digital data and the inpainted set of digital data to obtain a quantitative measure of the degree of calcification of the blood vessel.Type: ApplicationFiled: June 2, 2006Publication date: August 27, 2009Applicant: Nordic Bioscience A/SInventors: Marleen De Bruijne, Mads Nielsen, Claus Christiansen, Lars A. Conrad-Hansen, Francois B. Lauze
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Publication number: 20090204338Abstract: A computer-implemented method of processing an image of at least part of a blood vessel to derive a measure indicative of the instability of calcific deposits in the blood vessel, said blood vessel containing at least one calcific deposit, comprises locating and annotating one or more calcific deposits. Using information derived from the annotation of said calcific deposits, the method further comprises calculating a measure reflecting either one or both of a) the aggregate of the deviations from roundness of individual calcific deposits, and b) up to at least a threshold value, the extent to which the separate calcific deposits are spaced from one another.Type: ApplicationFiled: February 13, 2008Publication date: August 13, 2009Inventors: Mads Nielsen, Francois B. Lauze, Marleen De Bruijne, Erik B. Dam, Morten A. Karsdal, Claus Christiansen
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Publication number: 20090190815Abstract: A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure of local curvature of the cartilage is determined within a region of interest. The value of the quantitative parameter of this joint derived from this measure is compared with the value of a similar quantitative parameter previously established in respect of healthy joints and/or joints characterised by a pathology.Type: ApplicationFiled: September 4, 2006Publication date: July 30, 2009Applicant: Nordic Bioscience A/SInventors: Erik B. Dam, Jenny Folkesson, Paola Petterson, Ole F. Olsen, Mads Nielsen, Claus Christiansen
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Patent number: 7561727Abstract: A method of deriving a quantitative measure of a degree of calcification of a blood vessel such as an aorta by processing an image such as an X-ray image of at least a part of the blood vessel containing said calcification comprises: taking a starting set of digital data representative of an image of at least part of a blood vessel containing a calcification set against a background; estimating the boundary of the calcification; using inpainting to replace digital data in said starting set representing the calcification with data extrapolating the boundary of the background to extend over the area of calcification, and so generating an inpainted set of digital data; and computing the difference between the starting set of digital data and the inpainted set of digital data to obtain a quantitative measure of the degree of calcification of the blood vessel.Type: GrantFiled: October 10, 2005Date of Patent: July 14, 2009Assignee: Nordic Bioscience Imaging A/SInventors: Lars A. Conrad-Hansen, Marleen de Bruijne, Francois Bernard Lauze, Claus Christiansen, Mads Nielsen
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Publication number: 20090048157Abstract: This invention relates generally to calcitonin and their use in bone growth. Specifically, the invention relates to the use of calcitonin, e.g. salmon calictonin, to stimulate new bone formation in patients in need thereof.Type: ApplicationFiled: October 10, 2005Publication date: February 19, 2009Inventors: Moise Azria, Claus Christiansen
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Patent number: 7463758Abstract: A method of deriving a quantitative measure of a degree of calcification of a blood vessel such as an aorta by processing an image such as an X-ray image of at least a part of the blood vessel containing said calcification comprises: taking a starting set of digital data representative of an image of at least part of a blood vessel containing a calcification set against a background; estimating the boundary of the calcification; using inpainting to replace digital data in said starting set representing the calcification with data extrapolating the boundary of the background to extend over the area of calcification, and so generating an inpainted set of digital data; and computing the difference between the starting set of digital data and the inpainted set of digital data to obtain a quantitative measure of the degree of calcification of the blood vessel.Type: GrantFiled: June 2, 2005Date of Patent: December 9, 2008Assignee: Nordio Bioscience A/SInventors: Lars A. Conrad-Hansen, Marleen de Bruijne, Francois Bernard Lauze, Claus Christiansen, Mads Nielsen