Patents by Inventor Claus-Dieter Graf

Claus-Dieter Graf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of enantiomeric forms of 2,3-diaminopropionic acid derivatives
    Patent number: 9434696
    Abstract: The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: September 6, 2016
    Assignee: Sanofi
    Inventors: Claus-Dieter Graf, Joerg Rieke-Zapp
  • PROCESS FOR THE PREPARATION OF ENANTIOMERIC FORMS OF 2,3-DIAMINOPROPIONIC ACID DERIVATIVES
    Publication number: 20150018554
    Abstract: The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 15, 2015
    Inventors: Claus-Dieter GRAF, Joerg RIEKE-ZAPP
  • Process for the preparation of enantiomeric forms of 2,3-diaminopropionic acid derivatives
    Patent number: 8877926
    Abstract: The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: November 4, 2014
    Assignee: Sanofi
    Inventors: Claus-Dieter Graf, Joerg Rieke-Zapp
  • PROCESS FOR THE PREPARATION OF TRYPTASE INHIBITORS
    Publication number: 20110015400
    Abstract: This invention is directed to processes for the preparation of a compound of the formula I or salt thereof, that is useful as a tryptase inhibitor, to intermediates useful in the preparation of such a compound, to processes for the preparation of such intermediates, and to the use of such intermediates for the preparation of such a compound.
    Type: Application
    Filed: September 30, 2010
    Publication date: January 20, 2011
    Applicants: Sanofi-Aventis Deutschland GmbH, sanofi-aventis US LLC
    Inventors: Claus-Dieter GRAF, Christoph Tappertzhofen, Adam W. Sledeski
  • NOVEL DIPHENYLAZETIDINONE SUBSTITUTED BY PIPERAZINE-1-SULFONIC ACID AND HAVING IMPROVED PHARMACOLOGICAL PROPERTIES
    Publication number: 20090264402
    Abstract: The invention therefore relates to the compound of the formula I or a pharmaceutically acceptable salt thereof, its pharmaceutically composition and uses.
    Type: Application
    Filed: April 30, 2009
    Publication date: October 22, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Gerhard Jaehne, Wendelin Frick, Andreas Lindenschmidt, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer, Claus-Dieter Graf, Wolfgang Schmider
  • Process for the preparation of tryptase inhibitors
    Publication number: 20070197597
    Abstract: This invention is directed to processes for the preparation of a compound of the formula I or salt thereof, that is useful as a tryptase inhibitor, to intermediates useful in the preparation of such a compound, to processes for the preparation of such intermediates, and to the use of such intermediates for the preparation of such a compound.
    Type: Application
    Filed: September 1, 2006
    Publication date: August 23, 2007
    Applicants: Sanofi-Aventis Deutschland GmbH, sanofi-aventis US LLC
    Inventors: Claus-Dieter Graf, Christoph Tappertzhofen, Adam Sledeski