Abstract: The present invention refers to BMP8B-inhibitor for use in a method of preventing and/or treating liver fibrosis and/or liver cancer, wherein the inhibitor is an oligonucleotide, an antibody or fragment thereof, a small molecule or a combination thereof. Further, the invention is directed to a method for diagnosing liver fibrosis and/or liver cancer and a kit for diagnosing fibrosis and/or cancer. The method and the kit can be used to identify a subject in need for a BMP8B-inhibitor to prevent and/or treat liver fibrosis and/or liver cancer.

Abstract: The invention relates to a hops-based substance which comprises a mixture of (a) xanthohumol with the formula (1) and (b) at least one isomerized hops acid, preferably iso-alpha acid, in each case in a concentrated or isolated form. It has surprisingly been shown that a substance in which xanthohumol and iso-alpha acid are present in combination and in which each substance is present in a concentrated or isolated form in the combination substantially increases the effectiveness in conjunction with the prevention and/or control of liver diseases or liver damage when compared to xanthohumol alone. The inflammation- and fibrosis-inhibiting effect of xanthohumol and the inhibition of the fatty changes of liver cells is thus surprisingly increased by the presence of iso-alpha acid.

Abstract: A method for preventing and/or treating the formation of liver injury resulting from lipid accumulation in hepatocytes and/or inflammation of liver tissue and/or fibrosis in liver tissue and/or Non-Alcoholic Steatohepatitis (NASH) and/or alcoholic consumption and/or other toxic causes of liver injury by is performed by administering of iso-alpha-acid. An oral composition may be used.

Abstract: Method for the prevention and/or control of liver diseases, such as non-alcoholic steatohepatitis (NASH) even when eating a high fat diet. Prevention of NASH can be accomplished by preventing the liver from becoming a fatty liver even when eating a high fat diet by providing xanthohumol as a supplement to the high fat diet.

Abstract: The present invention relates to the human and murine melanoma inhibitory activity protein-2 (MIA-2) and to the nucleic acids encoding said proteins including a method for producing such proteins by recombinant techniques. The invention also relates to methods for utilizing such proteins for tissue regeneration, tumor treatment including to control the proliferation and differentiation of liver cells in vivo and in vitro. The invention further relates to diagnostic assays including the human and murine antibodies or aptamers and their use in therapy and diagnosis. Further it relates to diagnostic assays applying specific primers for the diagnostic of liver disease.

Abstract: The present invention relates to the use of xanthohumol with formula (I) as an agent for the production of a preparations for preventing and/or combating liver diseases.

Abstract: The present invention relates to the human and murine melanoma inhibitory activity protein-2 (MIA-2) and to the nucleic acids encoding said proteins including a method for producing such proteins by recombinant techniques. The invention also relates to methods for utilizing such proteins for tissue regeneration, tumor treatment including to control the proliferation and differentiation of liver cells in vivo and in vitro. The invention further relates to diagnostic assays including the human and murine antibodies or aptamers and their use in therapy and diagnosis. Further it relates to diagnostic assays applying specific primers for the diagnostic of liver disease.