Patents by Inventor Claus J. Schmitges

Claus J. Schmitges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endothelin receptor antagonists
    Patent number: 5821256
    Abstract: Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and X have the meaning indicated in claim 1, and their salts exhibit endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: October 13, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5731321
    Abstract: Novel compounds of the formula I ##STR1## in which --Y--Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings as stated in the specification, and their salts show endothelin receptor antagonist properties.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: March 24, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Mathias Osswald, Dieter Dorsch, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5700807
    Abstract: Novel compounds of the formula ##STR1## in which --Y--Z--, R.sup.1 R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the meaning indicated and their salts show endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: December 23, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Mathias Osswald, Dieter Dorsch, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Peptide analogues
    Patent number: 5401722
    Abstract: New peptide analogues of the formula IR.sup.1 --Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CH.sub.2).sub.o --(CR.sup.5).sub.t --(CH.sub.2).sub.v --CE--C.sub.w H.sub.2w --R.sup.6 Iin which R.sup.1 to R.sup.6 Z, E, o, t and w have the meanings described herein, and the salts thereof, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: March 28, 1995
    Inventors: Horst Juraszyk, Peter Raddatz, Johannes Sombroek, Claus J. Schmitges, Klaus-Otto Minck
  • Amino acid derivatives
    Patent number: 5378691
    Abstract: New amino acid derivatives of the formula IR.sup.1 --C.sub.p H.sub.2p --(NH).sub.y --CO--NH--CHR.sup.2 --CO--Z--C.sub.m H.sub.2m --CO--NH--CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--Q--Y Iin which R.sup.1 to R.sup.5, p, y, Z, m, n, E, Q and Y have the meanings defined herein, and the salts thereof, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: January 3, 1995
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Peter Raddatz, Joachim Gante, Johannes Sombroek, Claus J. Schmitges, Klaus-Otto Minck
  • Heterocyclic compounds useful for inhibition of renin
    Patent number: 5328916
    Abstract: New heterocyclic compounds of the formulaX--W--CR.sup.1 R.sup.2 --CO--Y--NR.sup.3 --CHR.sup.4 --CR.sup.5 --CH.sub.2 --(CR.sup.6 R.sup.7).sub.r --Z--Het Iin which R.sup.1 to R.sup.7, W, X, Y, Z, r and Het have the meanings defined herein, and the salts thereof, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: May 2, 1991
    Date of Patent: July 12, 1994
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Peter Raddatz, Claus J. Schmitges, Klaus-Otto Minck
  • Aminoacid derivatives inhibiting renin
    Patent number: 5215967
    Abstract: New amino acid derivatives of the formulaR.sup.1 --Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.a --CO--E--Q--Ywherein R.sup.1 to R.sup.5, a, Z, E, Q and Y have the meanings defined herein, and salts thereof inhibit the activity of human plasma renin.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: June 1, 1993
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Joachim Gante, Peter Raddatz, Johannes Sombroek, Claus J. Schmitges, Klaus O. Minck
  • Peptide and renin inhibitors
    Patent number: 5215966
    Abstract: Novel amino acid derivatives of the formula IX--Z--NH--CHR.sup.1 --CO--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--W'--Ywherein X, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, W', Y and n have the meanings defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: June 1, 1993
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Gunter Holzemann, Peter Raddatz, Claus J. Schmitges, Klaus Otto Minck, Alfred Jonczyk, Johannes Sombroek, Joachim Gante
  • Glycolic acid derivatives
    Patent number: 5147857
    Abstract: New glycolic acid derivatives of the formula IX--O--CR.sup.1 R.sup.2 --CO--Y--NR.sup.3 --CHR.sup.4 --CR.sup.5 --CH.sub.2 --CR.sup.6 R.sup.7 --Z Iin which R.sup.1 to R.sup.7, X, Y and Z have the meanings indicated herein, and salts thereof, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: September 15, 1992
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Peter Raddatz, Claus J. Schmitges, Klaus-Otto Minck
  • Amino acid derivatives
    Patent number: 4829053
    Abstract: New aminoacid derivatives of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--NR.sup.6 --(CHR.sup.7).sub.s --D Iwherein X, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, R.sup.6, R.sup.7, D, n and s have the meanings defined herein and their salts, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: May 9, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Peter Raddatz, Joachim Gante, Claus J. Schmitges, Klaus Otto Minck, Johannes Sombroek, Gunter Holzemann
  • Peptides possessing renin inhibitory activity
    Patent number: 4812555
    Abstract: New peptides of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CHOH--(CHR.sup.4).sub.n --CO--Ewherein X, Z, R.sup.2, R.sup.3, R.sup.4, E and n are as defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: March 14, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus O. Minck
  • 1,4-dihydropyridines
    Patent number: 4766213
    Abstract: Compounds of the formula ##STR1## are disclosed wherein the variables are herein described. These compounds are intermediates to compounds which influence the influx of calcium into the cell.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: August 23, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Horst Juraszyk, Rolf Gericke, Inge Lues, Rolf Bergmann, Claus J. Schmitges
  • Statine-containing peptides useful in medicaments
    Patent number: 4755592
    Abstract: New peptides of the formula IX--Z--W--E--W'--Y Iwherein X, Z, W, E, W' and Y are as defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: July 5, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus-Otto Minck, Hans-Eckart Radunz, Johannes Sombroek
  • Amino acid derivatives
    Patent number: 4721776
    Abstract: New amino acid derivatives of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CHR.sup.4 --(CHR.sup.5).sub.n CO--B--D Iin which X, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, B, D and n have the meanings defined herein, and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: January 26, 1988
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Claus J. Schmitges, Klaus O. Minck
  • Peptides useful for inhibition of renin
    Patent number: 4709010
    Abstract: New peptides of the formula IX--Z--NH--CHR--CHOH--CH.sub.2 --CO--NH--CHR.sup.1 --CH.sub.2 --NH--CHY--C.sub.n H.sub.2n --R.sup.2 Iin whichX is H, R.sup.3 --O--CH.sub.2 --CO--, R.sup.3 --O--CO--, R.sup.3 --CH.sub.2 --O--CO-- or R.sup.3 --C.sub.m H.sub.2m --CO--,Z is 1 to 4 aminoacid residues which are bonded together in the manner of peptides and are selected from the group comprising Abu, Ala, Arg, Asn, Dab, Gln, Gly, His, Ile, Leu, Lys, Met, NLeu, Orn, Phe, Pro, Trp, Tyr and Val,is A, Ar-alkyl (in which the group -alkyl contains 1-4 C atoms) or cycloalkyl-alkyl having 4-11 C atoms,R.sup.1 is H or A,Y is H, A, --C.sub.p H.sub.2p --OR.sup.4, --C.sub.p H.sub.2p --NHR.sup.4, --COOR.sup.4, --CONHR.sup.4 or --CONA.sub.2,R.sup.2 is A, cycloalkyl having 3-7 C atoms, Ar, pyridyl, indolyl, imidazolyl, piperidyl, N-benzylpiperidyl or piperazinyl,R.sup.3 is A, cycloalkyl having 3-7 C atoms or Ar,R.sup.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: November 24, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Gunter Holzemann, Peter Raddatz, Alfred Jonczyk, Claus J. Schmitges