Patents by Inventor Claus M. Krebber

Claus M. Krebber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of fatty alcohols from engineered microorganisms
    Patent number: 9714437
    Abstract: The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase (“FAR”); a gene encoding a heterologous thioesterase (“TE”) gene and a gene encoding an acyl-CoA synthetase (“ACS”).
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: July 25, 2017
    Assignee: Codexis, Inc.
    Inventors: Kaman Chan, Fernando Valle, Yoram Barak, Louis Clark, Kristian Karlshoej, Jonathan Vroom, Jovana Nazor, Claus M Krebber, Kenneth Mitchell
  • PRODUCTION OF FATTY ALCOHOLS FROM ENGINEERED MICROORGANISMS
    Publication number: 20160244787
    Abstract: The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase (“FAR”); a gene encoding a heterologous thioesterase (“TE”) gene and a gene encoding an acyl-CoA synthetase (“ACS”).
    Type: Application
    Filed: May 9, 2016
    Publication date: August 25, 2016
    Inventors: Kaman Chan, Fernando Valle, Yoram Barak, Louis Clark, Kristian Karlshoej, Jonathan Vroom, Jovana Nazor, Claus M Krebber, Kenneth Mitchell
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 8377681
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: February 19, 2013
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Stephen DelCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
  • EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
    Publication number: 20120252681
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Application
    Filed: December 2, 2011
    Publication date: October 4, 2012
    Applicant: CODEXIS MAYFLOWER HOLDINGS, LLC
    Inventors: Stephen del Cardayre, Matthew Tobin, Willem P.C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswaran Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 8076138
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: December 13, 2011
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Stephen DelCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
  • EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
    Publication number: 20110190140
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Application
    Filed: October 15, 2009
    Publication date: August 4, 2011
    Applicant: Maxygen, Inc.
    Inventors: Stephen del Cardayre, Matthew Tobin, Willem P.C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswatan Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 7629170
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: December 8, 2009
    Assignee: Maxygen, Inc.
    Inventors: Stephen delCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
  • IN-SOLUTION ACTIVATION OF FACTOR VII
    Publication number: 20090093616
    Abstract: The present invention is directed to a method for activation of Factor VII to FVIIa in solution.
    Type: Application
    Filed: May 27, 2008
    Publication date: April 9, 2009
    Inventors: Claus M. Krebber, Sridhar Viswanathan
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 7148054
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: December 12, 2006
    Assignee: Maxygen, Inc.
    Inventors: Stephen delCardayre, Matthew Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswatan Subramanian, Linda A. Castle, Claus M. Krebber, Steve Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • Evolution of whole cells and organisms by recursive sequence recombination
    Publication number: 20030148309
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites
    Type: Application
    Filed: July 11, 2002
    Publication date: August 7, 2003
    Applicant: Maxygen, Inc.
    Inventors: Stephen del Cardayre, Matthew Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswatan Subramanian, Linda A. Castle, Claus M. Krebber, Steven Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 6528311
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: March 4, 2003
    Assignee: Maxygen, Inc.
    Inventors: Stephen delCardayre, Matthew Tobin, William P. C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswaran Subramanian, Linda Castle, Claus M. Krebber, Steve Bass
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 6352859
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: March 5, 2002
    Assignee: Maxygen, Inc.
    Inventors: Stephen delCardayre, Matthew Tobin, William P. C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswatan Subramanian, Linda Castle, Claus M. Krebber, Steve Bass
  • Method for producing polynucleotides with desired properties
    Patent number: 6337186
    Abstract: The invention provides methods for the production of polynucleotides with a desired property (e.g., conferring a desired phenotype and/or encoding polypeptide with a desired property) which is selectable or can be screened for. The method includes making insertions and/or deletions at random sites in DNA segments in a population. In some embodiments the random insertions and deletions are made recursively.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: January 8, 2002
    Assignee: Maxygen, Inc.
    Inventor: Claus M. Krebber
  • Evolution of whole cells and organisms by recursive sequence recombination
    Patent number: 6287862
    Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 11, 2001
    Assignee: Maxygen, Inc.
    Inventors: Stephen delCardayre, Matthew Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswaran Subramanian, Linda Castle, Claus M. Krebber, Steven H. Bass