Abstract: The presently disclosed subject matter provides uses of anti-B7H3 antibodies for treating cancers in the central nervous system (CNS), including tumors metastatic to CNS, and in particular leptomeningeal carcinomatosis.

Abstract: A refillable injection device (1) having a dose setting mechanism with a dose setting member (4) and a dose rod (11). The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge. The dose setting member and the dose rod need to be moved into engagement when a new cartridge is inserted in the injection device. Thereby there is a risk that stress is build-up in the piston rod. In order to prevent this, the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an axial direction, at least while the dose setting member and the dose rod are moved into engagement.

Abstract: A medication dispensing device with a housing and a member wherein the member is moveable in a distal direction is useful in delivering medication to a patient. A fluid container can be used with the device and often has a moveable piston at one end and an outlet at the other. The member receives a force from a user and drives the piston in the distal direction to expel medication. A intermediate system is disposed between the member and the piston including a gear set that has a pinion in meshed engagement with a rack. The system allows the member to move a greater distance than the piston moves thereby increasing the force on the piston.

Abstract: A medication dispensing device with a housing and a member wherein the member is moveable in a distal direction is useful in delivering medication to a patient. A fluid container can be used with the device and often has a moveable piston at one end and an outlet at the other. The member receives a force from a user and drives the piston in the distal direction to expel medication. A intermediate system is disposed between the member and the piston including a gear set that has a pinion in meshed engagement with a rack. The system allows the member to move a greater distance than the piston moves thereby increasing the force on the piston.

Abstract: The invention relates to an impulse chamber which can be used for expelling an amount of a fluid compound at a high pressure. The impulse chamber comprises a variable-volume impulse chamber adapted for containing a volume of a flowable drug, an outlet nozzle in fluid communication with the impulse chamber and being adapted to be arranged against the skin of a subject, and a fluid inlet in fluid communication with the impulse chamber. The impulse chamber is defined substantially by a deformable chamber portion, such that deformation thereof reduces the volume of the cavity. In an exemplary embodiment the compressible chamber portion is in the form of an elastomeric tube, this providing a simple, yet reliable and cost-effective impulse chamber unit.

Abstract: A medical device is provided comprising a reservoir adapted to contain a fluid drug in an interior thereof, and a pump assembly. The pump assembly comprises a pump inlet, a pump outlet and an internal flow path arranged there between, and a fluid connector having an inlet and an outlet. The fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly.

Abstract: The present invention relates to a locking arrangement for detachably locking a cap having a skirt on a container having an enclosure opening into an opening. The cap includes a number of keys spaced along the inside of the skirt of the cap and a number of projections spaced along the outside of the enclosure of the container in an area having a mainly circular cross section and defining an axis. The locking arrangement also includes a slot made in each projection and having a base at the opening of the container and the opposite inlet for insertion of a key. Cooperative contact faces are made on the skirt and enclosure respectively and seen in cross section, they form an angle with each other. The contact faces of the cap are made on the inside of the skirt and/or the free ends of the keys and the contact faces of the container are made on the projections and/or the enclosure at a greater distance from the axis than the contact faces of the cap.

Abstract: An injection device for injection of set doses of medicine from a cartridge, in which syringe a dose is set by screwing a nut up along a threaded piston rod, whereby a dose setting drum, which carries on its cylindrical surface along a helix a scale of which a number corresponding to the set dose is shown in a window in the housing of the syringe, and an injection button, which is elevated over the end of the syringe, are moved axially a distance which is larger than the axial movement of the nut. A gear wheel transmission is established between the nut and the injection button.