Patents by Inventor Clay A. Brown

Clay A. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE-CHAIN ANTIBODY AGAINST FLAVIVIRUS NS1 PROTEIN
    Publication number: 20240002479
    Abstract: The disclosure is directed to binding agents, e.g., a single chain variable fragment (scFv) that specifically binds to a flavivirus NS1 protein, as well as compositions comprising the binding agent and a method of using such compositions to induce an immune response against a flavivirus (e.g., a dengue virus). The disclosure also provides a conjugate comprising the binding agent, and a recombinant NS1 antigen.
    Type: Application
    Filed: November 23, 2021
    Publication date: January 4, 2024
    Inventors: Janet L. Smith, David L. Akey, William Clay Brown, Eva Harris, Scott B. Biering, P. Robert Beatty
  • Vaccine compositions and uses thereof
    Patent number: 10046045
    Abstract: The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic and therapeutic uses of NS1 to treat and prevent disease caused by flaviviruses.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 14, 2018
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, PURDUE RESEARCH FOUNDATION
    Inventors: Janet L. Smith, David L. Akey, W. Clay Brown, Richard J Kuhn
  • VACCINE COMPOSITIONS AND USES THEREOF
    Publication number: 20160317644
    Abstract: The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic and therapeutic uses of NS1 to treat and prevent disease caused by flaviviruses.
    Type: Application
    Filed: December 19, 2014
    Publication date: November 3, 2016
    Inventors: Janet L. SMITH, David L. AKEY, W. Clay BROWN, Richard J KUHN
  • Protein purification tags and uses thereof
    Patent number: 8357511
    Abstract: The present invention relates to fusion proteins. In particular, the present invention relates to protein tags for use in protein solubilization and purification.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: January 22, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: William Clay Brown, James E. Delproposto, Janet Smith
  • PROTEIN PURIFICATION TAGS AND USES THEREOF
    Publication number: 20110165624
    Abstract: The present invention relates to fusion proteins. In particular, the present invention relates to protein tags for use in protein solubilization and purification.
    Type: Application
    Filed: July 31, 2009
    Publication date: July 7, 2011
    Applicant: THE REGENTS OF THEUNIVERSITY OF MICHIGAN
    Inventors: William Clay Brown, James E. Delproposto, Janet Smith
  • Surgical stapling device
    Patent number: 7059509
    Abstract: A surgical stapling device having a removable staple cartridge is disclosed. The cartridge includes a first opening in the staple-forming end of the housing member to allow access to the a staple and an aligned second opening to allow the lead staple to move therethrough. The staple cartridge also comprises a fixed blocking surface on the housing member and a traveling blocking surface on a feeder shoe. The traveling blocking surface is sized so that the feeder shoe moves relative to the fixed blocking surface while moving the staple. The feeder shoe is further shaped so that, when the trigger member is actuated when no staples remain in the staple cartridge, the staple former is not blocked by the feeder shoe.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: June 13, 2006
    Inventor: Phillip Clay Brown
  • Surgical stapling device
    Publication number: 20030222118
    Abstract: A surgical stapling device having a removable staple cartridge is disclosed. The cartridge includes a first opening in the staple-forming end of the housing member to allow access to the a staple and an aligned second opening to allow the lead staple to move therethrough. The staple cartridge also comprises a fixed blocking surface on the housing member and a traveling blocking surface on a feeder shoe. The traveling blocking surface is sized so that the feeder shoe moves relative to the fixed blocking surface while moving the staple. The feeder shoe is further shaped so that, when the trigger member is actuated when no staples remain in the staple cartridge, the staple former is not blocked by the feeder shoe.
    Type: Application
    Filed: August 26, 2002
    Publication date: December 4, 2003
    Applicant: TEMEDCO, Ltd.
    Inventor: Phillip Clay Brown
  • Ultravoilet, antibacterial, antifungal dryerlight
    Patent number: 5664340
    Abstract: A U.V. Anti-Bacterial, Anti-Fungal Dryer Light is provided designed to eliminate bacteria and fungus-causing germs from the laundry. The present invention consists of ultraviolet mechanisms situated within the door of typical gas and electric dryers thereby eliminating germs from the laundered clothing. Ultraviolet lights are contained within a dryer door-mounted plate and covered with clear glass or polycarbonate plastic. When the dryer is on, the ultraviolet lights will illuminate, thus beginning the process of abolishing the germs of the laundry.
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: September 9, 1997
    Inventor: Clay A. Brown