Patents by Inventor Clay M. Thompson

Clay M. Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10460439
    Abstract: Methods and systems for identifying biologic subtypes in a biological specimen may include receiving a data set associated with a cohort of biological specimens, determining a potential number of clusters associated with the data set, associating a cluster with one or more data points in the data set, associating a cluster label with the one or more data points in the data set, treating a related cluster as a biologic subtype and associating a biologic subtype with one or more data points with regions of interest in the data set, establishing duster features and metrics in the data set, determining if a new biologic subtype is identified by comparing the biologic subtype associated with the regions of interest with known biologic subtypes, and discovering a new diagnostic, prognostic, predictive, and/or therapeutic biologic subtype by correlating a new biologic subtype with patient, prognostic, predictive, therapeutic and/or clinical trial data.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 29, 2019
    Assignee: CIRECA THERANOSTICS, LLC
    Inventors: Stanley H. Remiszewski, Max Diem, Xinying Mu, Clay M. Thompson, Aysegul Ergin
  • Patent number: 10067051
    Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: September 4, 2018
    Assignees: CIRECA THERANOSTICS, LLC, NORTHEASTERN UNIVERSITY
    Inventors: Max Diem, Benjamin Bird, Milos Miljkovic, Stanley H. Remiszewski, Clay M. Thompson
  • Patent number: 10043054
    Abstract: Methods, systems, and devices for classifying a biological sample that include receiving an image of a biological sample and applying one or more algorithms from a data repository to the image, generating a classification of the biological sample based on the outcome of the one or more algorithms applied to the image, and transmitting the classification for presentation on a display or via another medium. The methods, systems, and devices may also include features for developing a data master reference and/or other correlation/translation features to enable comparison of data sets from one platform to another or from one machine to another or from the same machine at different points in time.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: August 7, 2018
    Assignee: CIRECA THERANOSTICS, LLC
    Inventors: Stanley H. Remiszewski, Max Diem, Clay M. Thompson, Aysegul Ergin, Xinying Mu, Mark Kon
  • Publication number: 20180180537
    Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
    Type: Application
    Filed: February 20, 2018
    Publication date: June 28, 2018
    Inventors: Max DIEM, Stanley H. Remiszewski, Clay M. Thompson
  • Publication number: 20180108163
    Abstract: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
    Type: Application
    Filed: December 7, 2017
    Publication date: April 19, 2018
    Inventors: Stanley H. REMISZEWSKI, Clay M. THOMPSON
  • Publication number: 20180025210
    Abstract: The methods, devices, and systems may allow a practitioner to obtain information regarding a biological sample, including analytical data, a medical diagnosis, and/or a prognosis or predictive analysis. The method, devices, and systems may provide a grade or level of development for identified diseases. In addition, the methods, devices and systems may generate a confidence value for the predictive classifications generated, which may, for example be generated in a format to show such confidence value or other feature in a graphical representation (e.g., a color code). Further, the methods, devices and system may aid in the identification and discovery of new classes and tissue sub-types.
    Type: Application
    Filed: September 18, 2017
    Publication date: January 25, 2018
    Inventors: Stanley H. REMISZEWSKI, Clay M. THOMPSON, Max DIEM, Aysegul ERGIN
  • Patent number: 9798918
    Abstract: The methods, devices, and systems may allow a practitioner to obtain information regarding a biological sample, including analytical data, a medical diagnosis, and/or a prognosis or predictive analysis. The method, devices, and systems may provide a grade or level of development for identified diseases. In addition, the methods, devices and systems may generate a confidence value for the predictive classifications generated, which may, for example be generated in a format to show such confidence value or other feature in a graphical representation (e.g., a color code). Further, the methods, devices and system may aid in the identification and discovery of new classes and tissue sub-types.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: October 24, 2017
    Assignee: CIRECA THERANOSTICS, LLC
    Inventors: Stanley H. Remiszewski, Clay M. Thompson, Max Diem, Aysegul Egin
  • Publication number: 20170061599
    Abstract: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
    Type: Application
    Filed: November 14, 2016
    Publication date: March 2, 2017
    Inventors: Stanley H. REMISZEWSKI, Clay M. THOMPSON
  • Patent number: 9495745
    Abstract: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: November 15, 2016
    Assignee: CIRECA THERANOSTICS, LLC
    Inventors: Stanley H. Remiszewski, Clay M. Thompson
  • Publication number: 20160110584
    Abstract: Methods, systems, and devices for classifying a biological sample that include receiving an image of a biological sample and applying one or more algorithms from a data repository to the image, generating a classification of the biological sample based on the outcome of the one or more algorithms applied to the image, and transmitting the classification for presentation on a display or via another medium. The methods, systems, and devices may also include features for developing a data master reference and/or other correlation/translation features to enable comparison of data sets from one platform to another or from one machine to another or from the same machine at different points in time.
    Type: Application
    Filed: October 19, 2015
    Publication date: April 21, 2016
    Inventors: Stanley H. REMISZEWSKI, Max DIEM, Clay M. THOMPSON, Aysegul ERGIN, Xinying MU, Mark KON
  • Publication number: 20160012591
    Abstract: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
    Type: Application
    Filed: August 4, 2015
    Publication date: January 14, 2016
    Applicant: CIRECA THERANOSTICS, LLC
    Inventors: Stanley H. REMISZEWSKI, Clay M. Thompson
  • Patent number: 9129371
    Abstract: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: September 8, 2015
    Assignee: CIRECA THERANOSTICS, LLC
    Inventors: Stanley Remiszewski, Clay M. Thompson
  • Publication number: 20150142333
    Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 21, 2015
    Inventors: Max DIEM, Benjamin BIRD, Milos MILJKOVIC, Stanley H. REMISZEWSKI, Clay M. THOMPSON
  • Patent number: 9025850
    Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: May 5, 2015
    Assignees: Cireca Theranostics, LLC, Northeastern University
    Inventors: Max Diem, Benjamin Bird, Milos Miljkovic, Stanley H. Remiszewski, Clay M. Thompson
  • Publication number: 20140286561
    Abstract: The methods, devices, and systems may allow a practitioner to obtain information regarding a biological sample, including analytical data, a medical diagnosis, and/or a prognosis or predictive analysis. The method, devices, and systems may provide a grade or level of development for identified diseases. In addition, the methods, devices and systems may generate a confidence value for the predictive classifications generated, which may, for example be generated in a format to show such confidence value or other feature in a graphical representation (e.g., a color code). Further, the methods, devices and system may aid in the identification and discovery of new classes and tissue sub-types.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 25, 2014
    Inventors: Stanley H. REMISZEWSKI, Clay M. Thompson, Max Diem, Aysegul Egin
  • Publication number: 20120328178
    Abstract: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
    Type: Application
    Filed: June 25, 2012
    Publication date: December 27, 2012
    Applicant: CIRECA THERANOSTICS, LLC
    Inventors: Stanley Remiszewski, Clay M. Thompson