Abstract: Systems and methods are disclosed for providing focused ultrasound treatment. A patient is screened to determine if focused ultrasound treatment is appropriate for the patient to treat a disorder. The patient is monitored to measure a plurality of wellness-related parameters for the patient and detect or predict an onset of symptoms associated with the disorder from the wellness-related parameters if focused ultrasound treatment has been determined to be appropriate. A personalized location for focused ultrasound treatment is determined for the patient according to at least one of the wellness-related parameters. At least one parameter associated with the focused ultrasound treatment is selected according to at least one of the wellness-related parameters. Focused ultrasound treatment is provided to the patient at the selected location using the selected at least one parameter.

Abstract: Compositions of nanoparticles and surfactants for enhanced gas lift through increased foaming heights and foam stability are disclosed. More specifically, synergistic combination of nanoparticles, including amine functionalized colloidal nanoparticles and surfactants, provides enhanced gas lift and increased oil production are disclosed. Methods of using are also disclosed.

Abstract: Systems and methods are disclosed for providing focused ultrasound treatment. A patient is screened to determine if focused ultrasound treatment is appropriate for the patient to treat a disorder. The patient is monitored to measure a plurality of wellness-related parameters for the patient and detect or predict an onset of symptoms associated with the disorder from the wellness-related parameters if focused ultrasound treatment has been determined to be appropriate. A personalized location for focused ultrasound treatment is determined for the patient according to at least one of the wellness-related parameters. At least one parameter associated with the focused ultrasound treatment is selected according to at least one of the wellness-related parameters. Focused ultrasound treatment is provided to the patient at the selected location using the selected at least one parameter.

Abstract: Systems and methods are provided for generating a clinical parameter for a user. A first plurality of wellness-relevant parameters representing the user are monitored at a physiological sensing device over a defined period. A second plurality of wellness-relevant parameters representing the user are obtained via a portable computing device. A third plurality of wellness-relevant parameters representing the user are retrieved from an electronic health records (EHR) system. A set of aggregate parameters are generated from the sets of wellness-relevant parameters, with each of the set of aggregate parameters comprising a unique proper subset of the parameters in the sets of wellness-relevant parameters. A clinical parameter is assigned to the user via a predictive model according to a subset of the set of aggregate parameters. An intervention is provided to the user when the clinical parameter meets a threshold value specific to the patient.

Abstract: Systems and methods are disclosed for providing focused ultrasound treatment. A patient is screened to determine if focused ultrasound treatment is appropriate for the patient to treat a disorder. The patient is monitored to measure a plurality of wellness-related parameters for the patient and detect or predict an onset of symptoms associated with the disorder from the wellness-related parameters if focused ultrasound treatment has been determined to be appropriate. A personalized location for focused ultrasound treatment is determined for the patient according to at least one of the wellness-related parameters. At least one parameter associated with the focused ultrasound treatment is selected according to at least one of the wellness-related parameters. Focused ultrasound treatment is provided to the patient at the selected location using the selected at least one parameter.

Abstract: Systems and methods are provided for monitoring a wellness of a user. A wellness-relevant parameter representing the user is monitored at a portable device over a defined period to produce a time series for the wellness-relevant parameter. A first set and a second set of either cognitive assessment data or psychosocial assessment data are obtained for the user at respective first and second times in the defined period. A value is assigned to the user via a predictive model according to the time series for the wellness-relevant parameter, the first set of either cognitive assessment data or psychosocial assessment data, and the second set of either cognitive assessment data or psychosocial assessment data.

Abstract: Methods are provided for providing anti-inflammatory activity and inhibiting a fibrotic disease, such as pulmonary fibrosis, in an individual. The methods comprise administering a biologically effective amount of latency-associated peptide (LAP) to the individual. Also provided are pharmaceutical compositions comprising LAP for use in accordance with these methods.

Abstract: 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2ylamino)phenyl]benzamide of the formula (I): or a pharmaceutically acceptable salt thereof for the treatment of inflammation.

Abstract: Methods are provided for providing anti-inflammatory activity and inhibiting a fibrotic disease, such as pulmonary fibrosis, in an individual. The methods comprise administering a biologically effective amount of latency-associated peptide (LAP) to the individual. Also provided are pharmaceutical compositions comprising LAP for use in accordance with these methods.