Patents by Inventor Clay Wang

Clay Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dereplication strain of
    Patent number: 10118945
    Abstract: Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include A. nidulans. The deleted gene clusters are selected from the group of gene clusters responsible for the biosynthesis of sterigmatocystin, emericellamides, asperfuranone, monodictyphenone, terrequinone, F9775A, F9775B, asperthecin, and both portions of the split cluster that makes austinol and dehydroaustinol. Methods for making compounds by culturing the fungus in a growth media and separating the compound from the fungus and/or separating the compound from the growth media are included, as are the compounds and compositions comprising them.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: November 6, 2018
    Assignees: University of Kansas, University of Southern California
    Inventors: Berl Oakley, Manmeet Ahuja, Ruth Entwistle, Christine Oakley, Yi-Ming Chiang, Clay Wang
  • DEREPLICATION STRAIN OF ASPERGILLUS NIDULANS
    Publication number: 20170121719
    Abstract: Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include A. nidulans. The deleted gene clusters are selected from the group of gene clusters responsible for the biosynthesis of sterigmatocystin, emericellamides, asperfuranone, monodictyphenone, terrequinone, F9775A, F9775B, asperthecin, and both portions of the split cluster that makes austinol and dehydroaustinol. Methods for making compounds by culturing the fungus in a growth media and separating the compound from the fungus and/or separating the compound from the growth media are included, as are the compounds and compositions comprising them.
    Type: Application
    Filed: October 31, 2016
    Publication date: May 4, 2017
    Inventors: Berl Oakley, Manmeet Ahuja, Ruth Entwistle, Christine Oakley, Yi-Ming Chiang, Clay Wang
  • EPIGENETIC MECHANISMS OF ANTI-FIBROTIC ACTION FOR THE LIVER
    Publication number: 20160106770
    Abstract: This invention demonstrates the therapeutic efficacy of Yang-Gan-Wan (YGW) and its active components, especially in the formulation provided by Sheng-Pu Pharmaceutials, Inc., for treating and preventing liver fibrosis. This invention further demonstrates MeCP2 is an important therapeutic target for YGW and its active ingredients' action against liver fibrosis and cirrhosis.
    Type: Application
    Filed: January 4, 2016
    Publication date: April 21, 2016
    Applicant: University of Southern California
    Inventors: Hidekazu Tsukamoto, Clay Wang