Abstract: An external filter assembly is shown having a slotted filter section, including an optional upper collar attached below the mounting member, and lower collar attached below the bottom cap of a lower filter element, where each collar includes a plurality of extensions containing magnets. Specifically, in the case of each extension, a bore is formed longitudinally within the extension, and a diametrically magnetic rare earth (neodymium) high-temperature rated magnet is permanently installed within the bore. Thus, with magnets installed in all of the extensions, metal debris passing through the assembly at any location, whether the upper collar or lower collar, is likely to be attracted to and retained by the extensions.

Abstract: The invention relates generally to antibodies, activatable antibodies, multispecific antibodies, and multispecific activatable antibodies that specifically bind to at least CD3, as well as to methods of making and using these antibodies, activatable antibodies, multispecific antibodies, and/or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: Systems, methods, and non-transitory computer-readable media can determine a set of candidate values for a field in a page. The set of candidate values can be evaluated for accuracy based at least in part on a machine learning model, wherein the machine learning model outputs a respective score for each candidate value that measures an accuracy of the candidate value for the field in the page. A best scoring candidate value can be determined from the set of candidate values. The field in the page can be associated with the best scoring candidate value.

Abstract: Systems, methods, and non-transitory computer-readable media can determine a set of candidate values for a field in a page. The set of candidate values can be evaluated for accuracy based at least in part on a machine learning model, wherein the machine learning model outputs a respective score for each candidate value that measures an accuracy of the candidate value for the field in the page. A best scoring candidate value can be determined from the set of candidate values. The field in the page can be associated with the best scoring candidate value.

Abstract: Systems and methods are provided for optimizing hemodynamics within a patient's heart, e.g., to improve the patient's exercise capacity. In one embodiment, a system is configured to be implanted in a patient's body to monitor and/or treat the patient that includes at least one sensor configured to provide sensor data that corresponds to a blood pressure within or near the patient's heart; at least one adjustable component designed to cause blood to flow in a direction opposite to the normal direction (regurgitation) within the patient's heart; and a controller configured for adjusting the function of the at least one adjustable component based at least in part on sensor data from the at least one sensor.

Abstract: Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume. The device includes an adjustable member that may create a mean pressure differential in order to manifest an effective “mechanical diuresis” by sequestering extraneous blood volume to the high-capacitance of the venous vasculature. The system is therefore designed to reduce intracardiac filling pressures while maintaining or even increasing cardiac output.

Abstract: Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume. The device includes an adjustable member that may create a mean pressure differential in order to manifest an effective “mechanical diuresis” by sequestering extraneous blood volume to the high-capacitance of the venous vasculature. The system is therefore designed to reduce intracardiac filling pressures while maintaining or even increasing cardiac output.

Abstract: A diffuser assembly is provided, comprising a diffuser adapted to reside within a conduit, having an upper member mountable within the conduit and having a fluid inlet port, and a lower section having a diffuser screen; a plurality of stationary diffusing members below the fluid inlet port, wherein the diffusing members are radially oriented relative to a central axis of the diffuser; and (c) a centralizing member above the diffuser screen having a diameter greater than the diffuser screen. The diffuser screen is a cylinder having a plurality of diffuser slots formed therein and a bottom cap having a fluid port; and each of the plurality of diffusing members extends substantially parallel to the central axis.

Abstract: A filter assembly is provided having a resilient member connected between an upper member and a lower section, wherein the resilient member enables the filter screen to vibrate relative to the upper member. A centralizing member is positioned above the filter screen having a diameter greater than the filter screen, wherein the filter screen is a cylinder having a plurality of filter apertures formed therein, and wherein the filter apertures extend substantially parallel to the central axis.

Abstract: A diffuser assembly is provided, comprising a diffuser adapted to reside within a conduit, having an upper member mountable within the conduit and having a fluid inlet port, and a lower section having a diffuser screen; a plurality of stationary diffusing members below the fluid inlet port, wherein the diffusing members are radially oriented relative to a central axis of the diffuser; and (c) a centralizing member above the diffuser screen having a diameter greater than the diffuser screen. The diffuser screen is a cylinder having a plurality of diffuser slots formed therein and a bottom cap having a fluid port; and each of the plurality of diffusing members extends substantially parallel to the central axis. The diffuser assembly may be positioned in different locations, including within a downhole carrier sub inside a well bore, within a drill pipe at the rig floor, or within a conduit in fluid communication between a mixing tank and a pump.

Abstract: A diffuser assembly is provided, comprising a diffuser adapted to reside within a conduit, having an upper member mountable within the conduit and having a fluid inlet port, and a lower section having a diffuser screen. A resilient member is connected between the upper member and the lower section, wherein the resilient member enables the diffuser screen to vibrate relative to the upper member. A plurality of diffusing members is positioned below the resilient member, wherein the diffusing members are oriented relative to a central axis of the diffuser screen. A centralizing member is positioned above the diffuser screen having a diameter greater than the diffuser screen. The diffuser screen is a cylinder having a plurality of diffuser apertures formed therein, the cylinder including a bottom cap having a fluid exit port; and wherein the plurality of diffusing members extends substantially parallel to the central axis.

Abstract: A diffuser assembly is provided which includes an upper mounting member mountable within a conduit and having an fluid inlet port, and a lower section having a diffuser screen. A plurality of radially oriented cutters are removably attached to the diffuser screen, and the cutters may extend internal or external to the diffuser screen. A first set of cutters is mounted at a first selected height along the central axis of the diffuser screen, and wherein a second set of cutters is mounted at a second selected height along the central axis of the diffuser screen. The diffuser assembly may be positioned in different locations, including within a downhole carrier sub inside a well bore, within a drill pipe at the rig floor, or within a conduit in fluid communication between a mixing tank and a pump.

Abstract: A diffuser assembly is provided, comprising a diffuser adapted to reside within a conduit, having an upper member mountable within the conduit and having a fluid inlet port, and a lower section having a diffuser screen. A resilient member is connected between the upper member and the lower section, wherein the resilient member enables the diffuser screen to vibrate relative to the upper member. A plurality of diffusing members is positioned below the resilient member, wherein the diffusing members are oriented relative to a central axis of the diffuser screen. A centralizing member is positioned above the diffuser screen having a diameter greater than the diffuser screen. The diffuser screen is a cylinder having a plurality of diffuser apertures formed therein, the cylinder including a bottom cap having a fluid exit port; and wherein the plurality of diffusing members extends substantially parallel to the central axis.

Abstract: A diffuser assembly is provided which includes an upper mounting member mountable within a conduit and having an fluid inlet port, and a lower section having a diffuser screen. A plurality of radially oriented cutters are removably attached to the diffuser screen, and the cutters may extend internal or external to the diffuser screen. A first set of cutters is mounted at a first selected height along the central axis of the diffuser screen, and wherein a second set of cutters is mounted at a second selected height along the central axis of the diffuser screen. The diffuser assembly may be positioned in different locations, including within a downhole carrier sub inside a well bore, within a drill pipe at the rig floor, or within a conduit in fluid communication between a mixing tank and a pump.

Abstract: A social networking system allows its users to provide metadata for association with objects maintained by the social networking system. Some of the metadata may be presented to other users along with the object. To prevent association of inaccurate metadata with an object, the social networking system determines a confidence value associated with a user who provided metadata for association with an object. The confidence value indicates of the accuracy of metadata provided by the user relative to information associated with the object. If the user has previously provided less than a threshold amount of metadata to associate with objects, the confidence score is determined using characteristics associated with the user by the social networking system. The metadata provided by the user is stored but not associated with the object if the user's confidence value is less than a threshold value.

Abstract: A downhole diffuser assembly comprising a diffuser adapted to reside within a carrier sub. The diffuser assembly includes an upper mounting member mountable within the carrier sub and having an fluid inlet port, and a lower section having a diffuser screen. A plurality of cutters are removably attached to the diffuser screen, wherein the cutters are radially oriented relative to a central axis of the diffuser screen. The cutters may extend internal or external to the diffuser screen, depending on the desired downhole conditions. In a preferred embodiment, a first set of cutters is mounted at a first selected height along the central axis of the diffuser screen, and wherein a second set of cutters is mounted at a second selected height along the central axis of the diffuser screen.

Abstract: Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume. The device includes an adjustable member that may create a mean pressure differential in order to manifest an effective “mechanical diuresis” by sequestering extraneous blood volume to the high-capacitance of the venous vasculature. The system is therefore designed to reduce intracardiac filling pressures while maintaining or even increasing cardiac output.

Abstract: Apparatus, systems, and methods are provided for optimizing intracardiac filling pressures and cardiac output in patients with heart failure, conduction disease, and atrial fibrillation. The system is able to adjust and optimize intracardiac filling pressures and cardiac output by adjusting heart rate and the effective amount of total body blood volume. The device includes an adjustable member that may create a mean pressure differential in order to manifest an effective “mechanical diuresis” by sequestering extraneous blood volume to the high-capacitance of the venous vasculature. The system is therefore designed to reduce intracardiac filling pressures while maintaining or even increasing cardiac output.

Abstract: A downhole diffuser assembly comprising a diffuser adapted to reside within a carrier sub. The diffuser assembly includes an upper mounting member mountable within the carrier sub and having an fluid inlet port, and a lower section having a diffuser screen. A plurality of cutters are removably attached to the diffuser screen, wherein the cutters are radially oriented relative to a central axis of the diffuser screen. The cutters may extend internal or external to the diffuser screen, depending on the desired downhole conditions. In a preferred embodiment, a first set of cutters is mounted at a first selected height along the central axis of the diffuser screen, and wherein a second set of cutters is mounted at a second selected height along the central axis of the diffuser screen.

Abstract: A social networking system allows its users to provide metadata for association with objects maintained by the social networking system. Some of the metadata may be presented to other users along with the object. To prevent association of inaccurate metadata with an object, the social networking system determines a confidence value associated with a user who provided metadata for association with an object. The confidence value indicates of the accuracy of metadata provided by the user relative to information associated with the object. If the user has previously provided less than a threshold amount of metadata to associate with objects, the confidence score is determined using characteristics associated with the user by the social networking system. The metadata provided by the user is stored but not associated with the object if the user's confidence value is less than a threshold value.