Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-readable media, for workflow generation using multiple interfaces. In some implementations, an interface for defining a workflow having one or more operations for a computer system to perform is provided. The interface can provide options that are selectable to cause an operation from a predetermined set of operations to be added to the workflow. Data indicating user selection of an option of the interface corresponding to a first operation in the predetermined set of operations is received. Code that specifies one or more custom operations is received. The workflow is defined to include (i) the first operation based on the data indicating the user selection and (ii) a second operation specified by the code.

Abstract: The present disclosure provides methods of treating venetoclax-resistant acute myeloid leukemia, including methods of identifying alternative treatment targets in specific subsets of patients who would otherwise be resistant to treatment with venetoclax and/or azacitidine.

Abstract: A method for extended authentication sessions on an electronic device may include an authentication service computer program executed by an authentication service electronic device: receiving a customer identifier for a customer and a unique identifier for a mobile electronic device; authenticating the customer based on the customer identifier and the unique identifier for the mobile electronic device; setting a device cookie that is specific to the mobile electronic device on the mobile electronic device; and providing the device cookie and a client secret to an OAuth services backend, wherein the OAuth services backend validates the customer identifier and client secret and generates a first token and a second token, the first token having an expiration that is shorter than that of the second token. The mobile electronic device is configured to receive and store the first token and the second token.

Abstract: A fluid design with enhanced proppant-carrying capacity utilizes a low-viscosity fluid with high proppant carrying capacity and low required power for injection into a hydrocarbon-bearing, subterranean formation. A preferred viscosifying agent that comprises a copolymer polymerized from an acrylic acid monomer and a monomer selected from: a) at least one carboxylic acid monomer; b) at least one C1 to C5 alkyl ester and/or at least one C1 to C5 hydroxyalkyl ester of acrylic acid or methacrylic acid; c) one crosslinking monomer; and optionally d) at least one ?,?-ethylenically unsaturated monomer, may be used to produce a fracturing fluid that has the pumpability of a slick water fluid and the proppant-carrying ability of a cross-linked gel. An optimization process to optimize hydraulic fracture design evaluates and quantifies the proppant-carrying capacity of the invented fluid and its impact in the proppant transport during fracturing.

Abstract: A grab bar assembly includes a support beam adapted to be mounted to a vehicle and defining a longitudinal axis, a grab bar having an inner beam disposed within the support beam and movable relative to the support beam in first and second directions along the longitudinal axis. The assembly further includes a locking plate attached to the inner beam and a locking mechanism coupled to the support beam and having a latch movable between a lock position engaging the locking plate to fix the grab bar in a location relative to the support beam and a release position disengaging the locking plate to permit adjustment of the grab bar and the inner beam along the longitudinal axis in one of the first and second directions.

Abstract: A network computing system provides an interactive menu to enable a consumer to initiate an order session. The network computing system can detect the order session is for placement of a group order, and can further provide a recommendation to the requesting consumer with respect to personalizing the group order for individual members of the group.

Abstract: A network computing system to coordinate a completion time of at least a portion of an order request with a target completion time, where the target completion time reflects an estimated time of arrival for a transportation provider with respect to a location of the supplier. The network computing system can coordinate the completion time by determining a timing of when at least a step in the preparation of at least the portion of the order request is performed by the supplier, based on an estimated arrival time of a transport provider. The network computing system can perform one or more control actions to influence the target completion time, based on the determined timing.

Abstract: A lever assembly (20) has a lever (24) mounted to a lever housing (22), a plunger (26), an auto-return housing (28) pivotable relative to the lever housing (22), a trigger mechanism (30) movable relative to the auto-return housing (28), and a yoke member (32) pivotable relative to the auto-return housing (22) independent of the auto-return housing. The trigger mechanism (30) is movable to an extended position in response to movement of the plunger (26) for engaging a cam element (12) of the steering column (10) for auto-return of the lever to a rest position. The yoke member (32) interacts with the plunger (26) when the plunger (26) pivots with the lever (24) to cause the yoke (32) to pivot toward an engaged position, and the yoke (32) interacts with the trigger mechanism (30) when the yoke (32) is pivoted to move the trigger mechanism (30) toward the extended position.

Abstract: The present disclosure relates to methods of identifying AML patients who will be resistant to venetoclax therapy and methods of treating venetoclax-resistant patients with myeloid leukemia cell differentiation protein (MCL-1) inhibitors.

Abstract: A grab bar assembly includes a support beam adapted to be mounted to a vehicle and defining a longitudinal axis, a grab bar having an inner beam disposed within the support beam and movable relative to the support beam in first and second directions along the longitudinal axis. The assembly further includes a locking plate attached to the inner beam and a locking mechanism coupled to the support beam and having a latch movable between a lock position engaging the locking plate to fix the grab bar in a location relative to the support beam and a release position disengaging the locking plate to permit adjustment of the grab bar and the inner beam along the longitudinal axis in one of the first and second directions.

Abstract: The present disclosure relates to compositions and methods for reducing cancer stem cells. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents.

Abstract: A lever assembly (20) has a lever (24) mounted to a lever housing (22), a plunger (26), an auto-return housing (28) pivotable relative to the lever housing (22), a trigger mechanism (30) movable relative to the auto-return housing (28), and a yoke member (32) pivotable relative to the auto-return housing (22) independent of the auto-return housing. The trigger mechanism (30) is movable to an extended position in response to movement of the plunger (26) for engaging a cam element (12) of the steering column (10) for auto-return of the lever to a rest position. The yoke member (32) interacts with the plunger (26) when the plunger (26) pivots with the lever (24) to cause the yoke (32) to pivot toward an engaged position, and the yoke (32) interacts with the trigger mechanism (30) when the yoke (32) is pivoted to move the trigger mechanism (30) toward the extended position.

Abstract: An inflatable antenna may include an inflatable sock, an antenna, and an attachment port. The inflatable sock may have an inflated state and a deflated state, where the inflatable sock assumes an elongated inflated shape in the inflated state. The antenna may extend along the length of the inflatable sock. The attachment port may be configured for operable connection to an inflation mechanism.

Abstract: A fluid design with enhanced proppant-carrying capacity utilizes a low-viscosity fluid with high proppant carrying capacity and low required power for injection into a hydrocarbon-bearing, subterranean formation. A preferred viscosifying agent that comprises a copolymer polymerized from an acrylic acid monomer and a monomer selected from: a) at least one carboxylic acid monomer; b) at least one C1 to C5 alkyl ester and/or at least one C1 to C5 hydroxyalkyl ester of acrylic acid or methacrylic acid; c) one crosslinking monomer; and optionally d) at least one ?,?-ethylenically unsaturated monomer, may be used to produce a fracturing fluid that has the pumpability of a slick water fluid and the proppant-carrying ability of a cross-linked gel. An optimization process to optimize hydraulic fracture design evaluates and quantifies the proppant-carrying capacity of the invented fluid and its impact in the proppant transport during fracturing.

Abstract: A network computing system provides an interactive menu to enable a consumer to initiate an order session. The network computing system can detect the order session is for placement of a group order, and can further provide a recommendation to the requesting consumer with respect to personalizing the group order for individual members of the group.

Abstract: Inflatable antenna assemblies are provided, including an inflatable container having an inflated state and a deflated state, the inflatable container having an interior surface and an exterior surface, a flexible antenna extending along the interior surface or the exterior surface of the inflatable container, such that the antenna deploys to an operable, extended configuration upon inflation of the inflatable container to the inflated state, and a port configured for operable connection to an inflation mechanism to inflate the container to the inflated state. Safety device structures, such as life rafts, life preservers, life jackets, buoys, and emergency beacons, having inflatable antenna portions, are also provided.

Abstract: A fluid design with enhanced proppant-carrying capacity utilizes a low-viscosity fluid with high proppant carrying capacity and low required power for injection into a hydrocarbon-bearing, subterranean formation. A preferred viscosifying agent that comprises a copolymer polymerized from an acrylic acid monomer and a monomer selected from: a) at least one carboxylic acid monomer; b) at least one C1 to C5 alkyl ester and/or at least one C1 to C5 hydroxyalkyl ester of acrylic acid or methacrylic acid; c) one crosslinking monomer; and optionally d) at least one ?,?-ethylenically unsaturated monomer, may be used to produce a fracturing fluid that has the pumpability of a slick water fluid and the proppant-carrying ability of a cross-linked gel. An optimization process to optimize hydraulic fracture design evaluates and quantifies the proppant-carrying capacity of the invented fluid and its impact in the proppant transport during fracturing.

Abstract: A shifter assembly selects a first mode and a second mode of a transmission for a vehicle. The shifter assembly includes a housing and a shift lever movably coupled to the housing and pivotable relative to the housing. The shift lever includes a body and a cap defining an aperture and being coupled to the body. The cap is rotatable relative to the body between a first and a second orientations. The shift lever further includes a toggle device partially received by the cap in the aperture with at least a portion of the toggle device being moveably coupled to the body between a rest and a depressed positions. The shift lever further includes an element mounted to the toggle device and rotatable with the cap between the first and the second orientations. The shift lever further includes a sensor system configured to interact with the element to detect rotation of the cap between the first and the second orientations.

Abstract: A shifter assembly selects a first mode and a second mode of a transmission for a vehicle. The shifter assembly includes a housing and a shift lever movably coupled to the housing and pivotable relative to the housing. The shift lever includes a body and a cap defining an aperture and being coupled to the body. The cap is rotatable relative to the body between a first and a second orientations. The shift lever further includes a toggle device partially received by the cap in the aperture with at least a portion of the toggle device being moveably coupled to the body between a rest and a depressed positions. The shift lever further includes an element mounted to the toggle device and rotatable with the cap between the first and the second orientations. The shift lever further includes a sensor system configured to interact with the element to detect rotation of the cap between the first and the second orientations.